The IU College of Arts & Sciences is the largest and oldest of Indiana University’s schools and is the institution’s intellectual core. The College offers 64 areas of study spanning the liberal arts and sciences, from the study of the birth of the universe to the latest scientific and technological advances, and encompassing the literatures and languages, history and arts, economics and politics of the world's cultures. At any one time, there are about 8,000 undergraduate majors and 2,800 graduate students pursuing degrees in the College.

The College counts cancer treatment pioneer Dr. Lawrence Einhorn, New York Times puzzle editor Will Shortz, and NBC journalist Jane Pauley among its alumni.