Indiana University, Bloomington
Research interests include regulation of CB1 cannabinoid receptor signaling, regulation of endocannabinoid production, role of endocannabinoids in synaptic plasticity, and novel cannabinoid receptors.
The Mackie lab examines the role and function of the endocannabinoid
system by using a combination of electrophysiological, imaging,
biochemical and immunological approaches. The endocannabinoid system
is comprised of cannabinoid receptors, endogenous cannabinoids
(endocannabinoids), and the enzymes that regulate the production and
degradation of endocannabinoids. ?9THC, the principal psychoactive
component of cannabis, interacts with this system to produce the
classic effects of cannabis intoxication. In addition, this system is
widely involved in multiple physiologically important processes
including memory, motivation, movement, analgesia, and emesis. "Through
our studies, we hope to better understand the implications of social
and therapeutic use of drugs that influence this fascinating system."
Office: (812) 855-2042; E-mail: firstname.lastname@example.org
Research information taken from: http://www.indiana.edu/~neurosci/faculty/mackie.html