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Ellen Ketterson Professor of Biology |
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Dale Sengelaub Professor of Psychology |
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Samrrah Raouf Technical Assistant |
| C E N T E R F O R T H E I N T E G R A T I V E S T U D Y O F A N I M A L B E H A V I O R |
| F A L L 1 9 9 5 G R A D U A T E S E M I NA R |
| HORMONES & BEHAVIOR: Methods in Behavioral and Neural Endocrinology (Z620 / P657) |
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Ellen Ketterson Professor of Biology |
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Dale Sengelaub Professor of Psychology |
and |
Samrrah Raouf Technical Assistant |
| PROSPECTUS . READINGS . CLASS SCHEDULE |
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C O U R S E D E S C R I P T I O N Both Sengelaub and Ketterson believe that graduate education should include course work in which students learn to do things. Our objective this semester is to provide access to some of the best scientists studying hormones and behavior and to learn from them how they do their science. By asking the speakers to emphasize their methods in their public presentations and to share their protocols with students, we hope to facilitate students' use of new techniques, as well as their ability to evaluate critically the work of others. A semester-long objective is to generate a Protocol Booklet, either bound or loose leaf, containing the protocols and their applications. Methods will include steroid autoradiography (Greg Ball), neuro-pharmacology (John Wingfield), egg yolk manipulations (Hubert Schwabl, also Barry Sinervo, local expert), immunocytochemistry (Peg McCarthy), micromanipulations of steroid metabolism (Barney Schlinger), isolation of hormone receptors (John Buntin), radioimmunoassay (Steve Schoech, local expert), and neuroanatomy (Ernie Nordeen). It is not realistic to hope that students will learn to perform all steps of a protocol in a class that meets only a few hours per week. Rather our goal for the class is to enable students to visualize these protocols in detail, knowing their uses and being aware of pitfalls. Format: The lectures will be periodic and public (see below). The class will meet each week on Monday afternoon, either to prepare for or meet with a visitor or local expert. We will meet in a classroom or a lab, as dictated by the speakers. Readings will be provided to help students prepare for visitors. Students enrolled in the class will have priority when it comes to meeting with visitors for meals and individually. Evaluation: Each student enrolled in the class will take major responsibility for one speaker and method. Depending on enrollment, students may work alone or in pairs. Through their own research and from information provided by the speakers, students will compile relevant citations (classic and current) and produce a document for each method for the Protocol Booklet. The document will summarize (1) the method's history, (2) its current place in the field, (3) materials needed, (4) steps involved, (5) cost, (6) time required for learning and for execution, (7) limitations, e.g., sources of error, and (8) hoped-for future developments. Students' performance will be evaluated based on level and quality of their participation in the class and on the quality of their contribution to the Protocol Booklet. Visiting Guest Lecturers: We are fortunate that the following researchers have agreed to visit campus and meet with the class: Ernie Nordeen (University of Rochester) |
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R E A D I N G S TEXTBOOK: There is no official text for the class. Those with less background may wish to consult the following: Becker, J.B., S.M. Breedlove, and D. Crews. 1992. Behavioral Endocrinology (MIT Press). Nelson, R.J. 1995. An Introduction to Behavioral Endocrinology (Sinauer Associates). READINGS to PREPARE for VISITORS: NORDEEN Nordeen, E.J. and K.W. Nordeen. 1994. Hormonally regulated neuron death in the avian brain. Seminars in the Neurosciences 6:299-306. Burek, M.J., K.W. Nordeen, and E.J. Nordeen. 1995. Initial sex differences in neuron growth and survival develp in the absence of afferent input. Journal of Neurobiology 27:85-96. Burek, M.J., K.W. Nordeen, and E.J. Nordeen. 1995. Estrogen promotes neuron addition to avian song control nucleus by regulating post mitotic events. Developmental Brain Research 85:220-224. SCHWABL Schwabl, H. 1993. Yolk is a source of maternal ttestosterone in developing birds. Proceedings of the National Academy of Science USA 90:11446-11450. Winckler, D.W. 1993. Testosterone in egg yolk: An ornithologists perspective. Proceedings of the National Academy of Science USA 90:11439-114421. Adkins-Regan, E., M.A. Ottinger, and J. Park. 1995. Maternal transfer of estradiol to egg yolks alters sexual differentiation of avian offspring. Journal of Experimental Zoology 271:466-470. McCARTHY McCarthy, M.M., D.B. Masters, K. Rimvall, S. Schwartz-Giblin and D.W. Pfaff. 1994. Intracerebral administration of antisense oligodeoxynucleotides to GAD65 and GAD67 mRNAs modulate reproductive behavior in the female rat. Brain Research 636: 209-220. McCarthy, M.M. 1995. Frank A. Beach Award. Functional significance of steroid modulation of GABAergic neurotransmission: Analysis at the behavioral, cellular and molecular level. Hormones and Behavior 29:131-140. McCarthy, M.M., L.C. Kaufman, P.J. Brooks, D.W. Pfaff and S.Schwartz-Giblin. 1995. Estrogen modulation of mRNA for the two forms of glutamic acid decarboxylase (GAD) in female rat brain. Journal of Comparative Neurology 362:1-13. BALL Ball, G.F., J.M. Casto, and D.J. Bernard. 1994. Sex differences in the volume of avian song control nuclei: Comparative studies and the issue of brain nucleus delineation. Psychoneuroendocrinology 19:485-504. Ball, G.F., P. Absil, and J. Balthazart. 1995. Peptidergic delineations of nucleus interface reveal a sex difference in volume. Neuroreport 6:957-960. Bernard, D.J. and G.F. Ball. 1995. Two histological markers reveal a similar photoperiodic difference in the volume of the high vocal center in male European starlings. Journal of Comparative Neurology 362:726-734. BUNTIN Buntin, J.D. and E. Ruzycki. 1987. Characteristics of prolactin binding sites in the brain of the ring dove (Streptopelia risoria). General and Comparative Endocrinology 65:243-253. Buntin, J.D., E. Ruzycki, and J. Witebsky. 1993. Prolactin receptors in dove brain: Autoradiographic analysis of binding characteristics in discrete brain regions and accessibility to blood-borne prolactin. Neuroendocrinology 57:738-750. WINGFIELD Wingfield, J. 1994. Modulation of the adrenocortical response to stress in birds. In: S. Tobe (Ed.) Perspectives in comparative endocrinology (National Research Council of Canada), pp. 520-528. Wingfield, J. et al. 1990. The "challenge hypothesis": Theoretical implications for patterns of testosteorne secretion, mating systems, and breeding strategies. American Naturalist 136:829-846. Wingfield, J. 1994. Hormone-behavior interactions and mating systems in male and female birds. In: R.V. Short & E. Balaban (Eds.) The differences between the sexes (University of Cambridge Press), pp. 303-330. SCHLINGER Schlinger, B. 1994. Estrogens to song: Picograms to sonograms. Hormones and Behavior 28:191-198. Schlinger, B. 1992. Circulating estrogens in a male songbird originate in the brain. Proceedings of the National Academy of Sciences USA 89:7650-7653. Schlinger, B. 1994. Neuronal and non-neuronal aromatase in primary cultures of developing zebra finch telecephalon. Journal of Neuroscience 14:7541-7552. |
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F A L L 1 9 9 5 C L A S S S C H E D U L E Meeting Time: 1:25 - 3:45 pm Mondays Location: CISAB seminar room, 402 N. Park Avenue Public Lectures: 11:30 am - 12:30 pm, Glen Black Lab, Room 101 (next to Mathers Museum, 9th & Fess St.) Plus: Informal meetings with visiting speakers, TBA; lab opportunities on Tues am September 4 -- Dale Sengelaub (Indiana University) September 11 -- Ernie Nordeen, Public talk: "Sexual Differentiation of Brain Regions Controlling Avian Song" September 18-- Hubert Schwabl, Public talk: "Maternal Hormones in the Development of Birds" September 25 -- Steve Schoech (Indiana University) October 2 -- Ellen Ketterson / Val Nolan (Indiana University) October 9 -- Peg McCarthy, Public talk: "Functional Significance of Steroid Modulation of GABAergic Neurotransmission in the Female Rat" October 16 -- Greg Ball, Public talk: "Sex and Seasonal Differences in the Avian Vocal Control System: What Exactly is Difference and Why?" October 23 -- Barry Sinervo (Indiana University) October 30 -- John Buntin, Public talk: ":Prolactin-Induced Changes in Behavior and Neuroendocrine Function in Birds: Insights from Prolactin Receptor Studies in the CNS" November 6 -- John Wingfield, Public talk: "Ecological Bases of Endocrine Phenomena" November 13 -- Jeff Schank (Indiana University) November 27 -- Barney Schlinger, Public talk: "Perspectives on Estrogen Physiology and Estrogen Control of Behavior in Songbirds" December 4 -- Summary |
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