Our lab is investigating new sampling and emitting techniques for electrospray ionization mass spectrometry (ESI-MS), matrix-assisted laser desorption/ionization (MALDI), and other MS methods. Through use of nanopipettes, or capillaries pulled to less than 100 nm in size, as sample emitters, higher signal-to-noise ratios are observed in MS analyses when compared to commercial ESI-MS emitters. Moreover, the size scale of nanopipettes is amenable to biological sampling. Together, these contributions sum to give improved mass spectra from biologically relevant systems.
Yuill, E.M.; Sa. N.; Ray, S.J.; Hieftje, G.M.; Baker, L.A. Electrospray ionization from nanopipette emitters with tip diameters of less than 100 nanometers, Anal. Chem., 2013, 85, 8498-8502. (http://dx.doi.org/10.1021/ac402214g)
Saha-Shah, A.; Weber, A.E.; Karty, J. A.; Ray, S. J.; Hieftje, G. M.; Baker, L. A. Nanopipettes: probes for local sample analysis, Chem. Sci., 2015, 6, 3334-3341. (http://dx.doi.org/10.1039/C5SC00668F)