Behavioral and Pharmacological Neuroscience at Indiana University

Preclinical Pharmacology Laboratory

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Jenelle Dorner

Contact Information

Telephone: (812-855-5351)
Email: jdorner@indiana.edu

Education

1999-B.S. University of Illinois, Champaign/Urbana, IL

2003-M.S. University of Illinois, Champaign/Urbana, IL

Honors and Awards

Chancellor's Fellowship for Graduate Study in Neuroscience

National Science Foundation Graduate Research Fellowship

Current Research Interests

My research focuses on evaluation of the neurophysiology and neurochemistry of the basal ganglia and related structures. These areas of the brain are involved in movement and also play a role in motivation, emotion and cognition. I am particularly interested in how alterations in basal ganglia function result in movement disorders that occur in conditions such as Huntington’s disease (HD), an inherited neurodegenerative condition that affects primarily the striatum and corticostriatal pathway.

To assess how basal ganglia structures and circuitry function, we use neurochemical (voltammetry) and electrophysiological (single-unit recording) techniques to measure neural activity and neurotransmitter function during behavior. My current projects focus on evaluating basal ganglia function in transgenic and knock-in mouse models of HD. Some of my current projects include: 1) evaluation of how glutamate transmission is modulated by ascorbate, a water-soluble vitamin to influence movement and neuronal activity in HD and wild type control mice; 2) behavioral characterization of the 140 CAG knock-in mouse model of HD; 3) evaluation of sex differences in basal ganglia function and the role of gonadal steroid hormones in the onset and progression of neurodegenerative diseases such as HD.


Personal Interests:

I spend most of my time outside of the laboratory with my husband and my infant son (who is already analyzing the world like a brilliant scientist). We enjoy gardening, camping, hiking and kayaking. I am also involved in disability advocacy and awareness and enjoy presenting to schools and community groups to educate others about disability, dystonia and movement disorders and the benefits of service dogs.

Curriculum Vitae

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