Behavioral and Pharmacological Neuroscience at Indiana University

Preclinical Neuropsychopharmacology Laboratory

Home People Former Members Research Publications Links FAQ

Publications

Groves, P. M., Wilson, C. J., Young, S. J., and Rebec, G. V. Self-inhibition by dopaminergic neurons: An alternative to the "neuronal feedback loop" hypothesis for the mode of action of certain psychotropic drugs. Science, 190:522-529, 1975.

Kamata, K. and Rebec, G. V. Dopaminergic and neostriatal neurons: Dose-dependent changes in sensitivity to amphetamine with long-term treatment. Neuropharmacology, 22:1377-1382, 1983.

Rebec, G. V. and Bashore, T. R. Critical issues in assessing the behavioral effects of amphetamine. Neuroscience and Biobehavioral Reviews, 8:153-159, 1984.

Alloway, K. D. and Rebec, G. V. Apomorphine-induced inhibition of neostriatal activity is enhanced by lesions induced by 6-hydroxydopamine but not by long-term administration of amphetamine. Neuropharmacology, 23:1033-1039, 1984.

Rebec, G. V., Centore, J. M., White, L. K., and Alloway, K. D. Ascorbic acid and the behavioral response to haloperidol: Implications for the action of antipsychotic drugs. Science, 227:438-440, 1985.

Anderson, G. D. and Rebec, G. V. Clozapine and haloperidol in the amygdaloid complex: Differential effects on dopamine transmission with long-term treatment. Biological Psychiatry, 23:497-506, 1988.

Rebec, G. V. and Curtis, S. D. Reciprocal zones of excitation and inhibition in the neostriatum. Synapse, 2:633-635, 1988.

Oh, C., Gardiner, T. W., and Rebec, G. V. Blockade of both D1 and D2 dopamine receptors inhibits amphetamine-induced ascorbate release in the neostriatum. Brain Research, 480:184-189, 1989.

White, L. K., Maurer, M., Kraft, M. E., Oh, C., and Rebec, G. V. Intrastriatal infusions of ascorbate antagonize the behavioral response to amphetamine. Pharmacology, Biochemistry, and Behavior, 36:485-489, 1990.

Basse-Tomusk, A. and Rebec, G. V. Regional distribution of ascorbate and 3,4-dihydroxyphenylacetic acid (DOPAC) in rat neostriatum. Brain Research, 538:29-35, 1991.

Rebec, G. V. Changes in brain and behavior produced by amphetamine: a perspective based on microdialysis, voltammetry, and single-unit electrophysiology in freely moving animals. In Biochemistry and Physiology of Substance Abuse, CRC Series Physiology of Drug Abuse, Volume III, R. R. Watson, Ed., CRC Press, Boca Raton, FL, pp. 93-115, 1991.

Haracz, J. L., Tschanz, J. T., Wang, Z., White, I. M., and Rebec, G. V. Striatal single-unit responses to amphetamine and neuroleptics in freely moving rats. Neuroscience and Biobehavioral Reviews, 17:1-12, 1993.

White, I. M. and Rebec, G. V. Responses of rat striatal neurons during performance of a lever-release version of the conditioned avoidance response task. Brain Research, 616:71-82, 1993.

Pierce, R. C. and Rebec, G. V. Intraneostriatal administration of glutamate antagonists increases behavioral activation and decreases neostriatal ascorbate via non-dopaminergic mechanisms. Journal of Neuroscience, 13:4272-4280, 1993

Tschanz, J. T., Griffith, K. E., Haracz, J. L., and Rebec, G. V. Cortical lesions attenuate the opposing effects of amphetamine and haloperidol on neostriatal neurons in freely moving rats. European Journal of Pharmacology, 257:161-167, 1994.

Rebec, G. V. and Pierce, R. C. A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission. Progress in Neurobiology, 43:537-565, 1994.

Kiyatkin, E. A. and Rebec, G. V. Dopaminergic modulation of glutamate-induced excitations of neurons in the neostriatum and nucleus accumbens of awake, unrestrained rats. Journal of Neurophysiology, 75:142-153, 1996.

Garris, P. A., Christensen, J. R. C., Rebec, G. V., and Wightman, R. M. Real-time measurement of electrically evoked extracellular dopamine in the striatum of freely moving rats. Journal of Neurochemistry, 68:152-161, 1997.

Rebec, G. V., Grabner, C. P., Pierce, R. C., and Bardo, M. T. Transient increases in catecholaminergic activity in the medial prefrontal cortex and nucleus accumbens shell during novelty. Neuroscience, 76:707-714, 1997.

Rebec, G. V., Christensen, J. R. C., Guerra, C., and Bardo, M. T. Regional and temporal differences in dopamine efflux in the nucleus accumbens during free-choice novelty, Brain Research, 776:61-67, 1997.

Rebec, G. V. Real-time assessments of dopamine function during behavior: Single-unit recording, iontophoresis, and fast-scan cyclic voltammetry in awake, unrestrained rats. Alcoholism: Clinical and Experimental Research, 22:32-40, 1998.

Kiyatkin, E. A. and Rebec, G. V. Heterogeneity of ventral tegmental area neurons: single-unit recording and iontophoresis in awake, unrestrained rats. Neuroscience, 85:1285-1309, 1998.

Kiyatkin, E. A. and Rebec, G. V. Striatal neuronal activity and responsiveness to dopamine and glutamate after selective blockade of D1 and D2 dopamine receptors in freely moving rats. Journal of Neuroscience, 19:3594-3609, 1999.

Rebec. G. V. Stimulants and motor-related striatal neuronal activity. In: Brain Dynamics and the Striatal Complex, Miller, R. and Wickens, J. R. (eds.), Conceptual Advances in Brain Research Series, Gordon and Breach, Reading, pp. 51-63, 2000.

Kiyatkin, E. A., Kiyatkin, D. E., and Rebec, G. V. Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience, 98:729-741, 2000.

Heidenreich, B. A. and Rebec, G. V. Effects of crus cerebri lesions and repeated amphetamine treatment on the activity of nigral dopaminergic neurons. Synapse, 38:80-86, 2000.

Rebec, G. V. and Wang, Z. Behavioral activation in rats require endogenous ascorbate release in striatum. Journal of Neuroscience, 21:668-675, 2001

Rebec, G. V., Barton, S. J., and Ennis, M. D. Dysregulation of ascorbate in the striatum of behaving mice expressing the Huntington’s disease gene. Journal of Neuroscience, 22:RC202 (1-5), 2002.

Gulley, J. M., Kosobud, A. E. K., and Rebec, G. V. Behavior-related modulation of substantia nigra pars reticulata neurons in rats performing a conditioned reinforcement task. Neuroscience, 111(2):337-349, 2002.

Garris, P. A. and Rebec, G. V. Modeling fast dopamine neurotransmission in the nucleus accumbens during behavior. Behavioural Brain Research, 137:47-63, 2002.

Sun, W. L. and Rebec, G. V. Lidocaine inactivation of ventral subiculum attenuates cocaine-seeking behavior in rats. Journal of Neuroscience, 23:10258-10264, 2003.

Rebec, G. V., Witowski, S. R., Sandstrom, M. I., Rostand, R. D., and Kennedy, R. T. Extracellular ascorbate modulates cortically evoked glutamate dynamics in rat striatum. Neuroscience Letters, 378:166-170, 2005.

Wood, D. A., Buse, J. E., Wellman, C. L., Rebec, G. V. Differential environmental exposure alters NMDA but not AMPA receptor subunit expression in nucleus accumbens core and shell. Brain Research, 1042:176-183, 2005.

Sun, W.L., Akins, C.K., Mattingly, A.E., and Rebec, G. V. Ionotropic glutamate receptors in the ventral tegmental area regulate cocaine-seeking behavior in rats. Neuropsychopharmacology, 30:2073-2081, 2005.

Ball, K.T. and Rebec, G.V. Role of 5-HT2A AND 5-HT2C/B receptors in the acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on striatal single-unit activity and locomotion in freely moving rats. Psychopharmacology (Berl), 181:676-687, 2005.

Rebec, G.V. and Sun, W.L.Neuronal substrates of relapse to cocaine-seeking behavior: role of prefrontal cortex. Journal of the Experimental Analysis of Behavior, 84(3): 653-666, 2005.

Rebec, G.V. Cocaine and amphetamines In: Encyclopedia of Life Sciences, www.els.net, Nature Publishing Group, Macmillan Publishers Ltd., England, 2005.

Rebec, G.V., Conroy, S.K., and Barton, S.J. Hyperactive striatal neurons in symptomatic Huntington R6/2 mice: Variations with behavioral state and repeated ascorbate treatment. Neuroscience, 137: 327-336, 2006.

Cortright, J.J. and Rebec, G.V. Ascorbate modulation of sensorimotor processing in striatum of freely moving rats. Brain Research, 1092(1): 108-116, 2006.

Wood, D.A., Siegel, A.K., and Rebec, G.V. Environmental enrichment reduces impulsivity during appetitive conditioning. Physiology and Behavior, 88(1-2): 132-137, 2006.

Kosobud, A.E.K., Kebabian, C.E., and Rebec, G.V. Nitrous oxide acutely suppresses ethanol consumption in HAD and P rats. International Journal of Neuroscience, 116:835-845, 2006.

Ball, K.T., Budreau, D., and Rebec, G.V. Context-dependent behavioral and neuronal sensitization in striatum to MDMA (ecstasy) administration in rats. European Journal of Neuroscience, 24:217-228, 2006.

Sun, W.L., and Rebec, G.V. Repeated cocaine self-administration alters processing of cocaine-related information in rat prefrontal cortex. Journal of Neuroscience, 26:8004-8008, 2006.

Rebec, G.V., Behavioral electrophysiology of psychostimulants. Neuropsychopharmacology, 31:2341-2348, 2006.

Rebec, G.V. From interferant anion to neuromodulator: ascorbate oxidizes its way to respectability. In: Electrochemical Methods in Neuroscience, Michael, A.C. Borland, L.M. (Eds.), Taylor Francis Group, CRC Press, Boca Raton, FL, pp. 149-165, 2007.

Garris, P.A., Greco, P.G., Sandberg, S.G., Howes, G., Pongmaytegul, S., Heidenreich, B.A., Casto, J.M., Ensman, R., Poehlman, J., Alexander, A., and Rebec, G.V. In vivo voltammetry with telemetry. In: Electrochemical Methods in Neuroscience, Michael, A.C. Borland, L.M. (Eds.), Taylor Francis Group, CRC Press, Boca Raton, FL, pp. 233-259, 2007.

Dorner, J.L., Miller, B.R., Barton, S.J., Brock, T.J., and Rebec, G.V. Sex differences in behavior and striatal ascorbate release in the 140 CAG knock-in mouse model of Huntington's disease. Behavioural Brain Research, 178:90-97, 2007.

Teagarden, M.A. and Rebec, G.V. Subthalamic and striatal neurons concurrently process motor, limbic, and associative information in rats performing an operant task. Journal of Neurophysiology, 97:2042-2058, 2007.

Sandstrom, M.I. and Rebec, G.V. Extracellular ascorbate modulates glutamate dynamics: role of behavioral activation. BMC Neuroscience, 8:32, 2007.

Ball, K.T., Walsh, K.M., and Rebec, G.V. Reinstatement of MDMA (ecstasy) seeking by exposure to drug-conditioned cues. Pharmacology, Biochemistry and Behavior, 87(4): 420-425, 2007.

Liu, X., Miller, B.R., Rebec, G.V., and Clemmer, D.E., Protein expression in the striatum and cortex regions of the brain for a mouse model of Huntington's disease. Journal of Proteome Research, 6(8): 3134-3142, 2007.

Kosobud, A.E.K., Gillman, A.G., Leffel II, J.K., Pecoraro, N.C., Rebec, G.V., and Timberlake, W. Drugs of abuse can entrain circadian rhythms. TheScientificWorldJOURNAL, 7:203-212, 2007

Miller, B.R., Dorner, J.L., Shou, M., Sari, Y., Barton, S.J., Sengelaub, D.R., Kennedy, R.T., and Rebec, G.V. Up-regulation of GLT1 expression increases glutamate uptake and improves the Huntington's disease phenotype. Neuroscience, 153(1):329-337, 2008.

Sunsay, C. and Rebec, G.V. Real-time dopamine efflux in the nucleus accumbens core during Pavlovian conditioning. Behavioral Neuroscience, 122(2):358-367, 2008.

Miller, B.R., Walker, A.G., Shah, A.S., Barton, S.J., and Rebec, G.V. Dysregulated information processing by medium-spiny neurons in striatum of freely behaving mouse models of Huntington's disease. Journal of Neurophysiology, 100(4):2205-2216, 2008.

Walker, A.G., Miller, B.R., Fritsch, J.N., Barton, S.J., and Rebec, G.V. Altered information processing in the prefrontal cortex of Huntington's disease mouse models. Journal of Neuroscience, 28(36):8973-8982, 2008.

Ball, K.T. and Rebec, G.V. Electrophysiological and Morphological Adaptations in Cortico-striato-limbic Circuitry Induced by 3,4-Methylenedioxymethamphetamine (MDMA; Ecstasy). In Nucleus Accumbens: Neurotransmitters and Related Behaviours, David, H. (ed.). Research Signpost: Kerala, India, 2008.

Wood, D.A. and Rebec, G.V. Environmental enrichment differentially alters neuronal processing in the nucleus accumbens core appetitive conditioning. Brain Research, 59-67, 2009
Ball, K.T., Wellman, C.L., Fortenberry, E., and Rebec, G.V. Sensitizing regimens of MDMA (Ecstasy) elicit enduring and differential structural alterations in the brain motive circuit. Neuroscience, 2009, Feb. 21 [Epub ahead of print]. (PMID: 19236907)

Fowler,S.C., Miller, B.R., Gaither, T.W., Johnson, M.A., and Rebec, G.V. Force-plate quantification of progressive behavioral deficits in the R6/2 mouse model of Huntington's disease. Behavioural Brain Research, 202: 130-137, 2009.

Sari Y, Smith K.D., Ali, P.K., and Rebec, G.V. Up-regulation of GLT1 attenuates cue-induced reinstatement of cocaine seeking in rats. Journal of Neuroscience, [Epub July 22, 2009).

Dorner, J.L, Miller, B.R., Klein, E.L., Murphy-Nakhnikian, A., Andrews, R.L., Barton, S.J., and Rebec, G.V. Corticostriatal dysfunction underlies diminished striatal ascorbate release in the R6/2 mouse models of Huntington's disease. Brain Research, 2009

Ball, K. T., Wellman, C. L., Fortenberry, E., & Rebec, G. V. (2009). Sensitizing regimens of MDMA (Ecstasy) elicit enduring and differential structural alterations in the brain motive circuit. Neuroscience, 60(2):264-274.  PMCID: PMC2669702

Fowler, S. C., Miller, B. R., Gaither, T. W., Johnson, M. A., & Rebec, G. V. (2009). Force-plate quantification of progressive  behavioral deficits in the R6/2 mouse model of Huntington’s disease. Behavioural Brain Research, 202, 130-137.

Sari, Y, Smith, K. D., Ali, P. K., & Rebec, G. V. (2009). Up-regulation of GLT1 attenuates cue-induced reinstatement of cocaine seeking in rats. Journal of Neuroscience, 29(29):9239-9243.  PMCID: PMC2737464

Dorner, J. L, Miller, B. R., Klein, E. L., Murphy-Nakhnikian, A., Andrews, R. L., Barton, S. J., & Rebec, G. V. (2009). Corticostriatal dysfunction underlies diminished striatal ascorbate release in the R6/2 mouse models of Huntington's disease.  Brain Research, 1290:111-120.  PMCID: PMC2745264

Sari, Y, Chiba, T.; Yamada, M., Rebec, G. V. & Aiso, A. (2009). A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience, 164:1653-1664.  PMCID: PMC2783970

Miller, B. R., Walker, A. G., Fowler, S. C., von Hörsten, S., Riess, O., Johnson, M. A., & Rebec, G. V. (2010). Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington’s disease. Neurobiology of Disease, 37(1):106-113.  PMCID: PMC2787873

Rebec, G. V. (2010). A central role for the periphery in the rapid action of cocaine on brain neurons:  focus on "Rapid EEG desynchronization and EMG activation induced by intravenous cocaine in freely moving rats: a peripheral, nondopamine neural triggering"Am J Physiol - Regulatory, Integrative and Comp Physiol, 298 (2):R283-284.

Sari, Y., Hammad, L. A. A., Saleh, M. M., Rebec, G. V., & Mechref, Y. (2010). Alteration of selective neurotransmitters in fetal brains of alcohol treated prenatally C57BL/6 mice: quantitative analysis using liquid chromatography/tandem mass spectrometry methods. International Journal of Developmental Neuroscience, 28:263-269.  NIHMSID NIHMS185575

Hall, I. C., Rebec, G. V., & Hurley, L. M. (2010). Serotonin in the inferior colliculus fluctuates with behavioral state and environmental stimuli.  Journal of Experimental Biology, 213:1009-1017.  PMID: 20228336.

Sari, Y., Prieto, A. L., Barton, S. J., Miller, B. R., & Rebec, G. V. (2010). Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington's disease.  Journal of Biomedical Science, 17, 62 (1-5).  PMCID: PMC2918547

Ball, K. T., Wellman, C. L., Miller, B. R., and Rebec, G. V. (2010). Electrophysiological and structural alterations in striatum associated with behavioral sensitization to (±)3,4-Methylenedioxymethamphetamine (Ecstasy) in rats:  Role of drug context.  Neuroscience, 171:794-811.  PMCID: PMC2987517

Wilber, A. A., Walker, A., Southwood, C. Rebec, G. V., and Wellman, C. (2011). Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction.  Neuroscience, 174:115-131.  PMCID: PMC3020264

Xue, Y. Q., Steketee, J., Rebec, G., & Sun, W. L. (2011). Activation of D2-like receptors in rat ventral tegmental area inhibits cocaine-reinstated drug seeking-behavior.  European Journal of Neuroscience, 33(7), 1291-1298.  PMCID: PMC3070830

Sari, Y., Sakai, M., Weedman J. M., Rebec G. V., & Bell R. L. (2011). Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats.  Alcohol and Alcoholism, 46(3), 239-246.  PMCID: PMC3104611

Wood, D. A., Walker, T. L. & Rebec G. V. (2011). Experience-dependent changes in neuronal processing in the nucleus accumbens shell in a discriminative learning task in differentially housed rats.  Brain Research, 1390, 90-98.  PMCID: PMC3085613

Walker, A.G., Ummel, J.R., & Rebec, G.V. (2011). Reduced expression of conditioned fear in the R6/2 mouse model of Huntington’s disease is related to abnormal activity in prelimbic cortex. Neurobiology of Disease, 43(2):379-387.  PMCID: PMC3114205 

Miller, B.R., Dorner, J.L., Gaither, T.W., Klein, E.L., Barton, S.J., & Rebec, G.V. (2011).  Dysregulated neuronal activity patterns implicate corticostriatal circuit dysfunction in multiple rodent models of Huntington’s disease.  Frontiers in Systems Neuroscience, 5:26, 1-10.[www.frontiersin.org - May 2011] PMCID: PMC3100808

Lu, L., Xue, Y., Steketee, J. D., Rebec, G. V., Sun, W. (2012).  Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area. Psychopharmacology (Berl). 220(1):75-85.  PMID: 21881873 [PubMed - in process]

Hong, S.L., Barton, S.J., & Rebec, G.V.  (2012). Altered neural and behavioral dynamics in Huntington's disease:  An entropy conservation approach.  PLoS ONE, 7 (1), e30879.  PMCID: PMC3264652

Murphy-Nakhnikian,  J. M., Dorner, J. L., Fischer, B. I., Bower-Bir, N. D., & Rebec, G. V. (2012). Abnormal burst patterns of single neurons recorded in the substantia nigra reticulata of behaving 140 CAG Huntington’s disease mice.  Neuroscience Letters, 512, 1-5.  PMCID: PMC3285379

Miller, B. R., Dorner, J. L., Bunner, K. D., Gaither, T. W., Klein, E. L., Barton, S. J., & Rebec, G. V. (2012). Upregulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington’s disease. Journal of Neurochemistry,  121, 629-638.  PMCID: PMC3325322

Fischer-Smith, K. D., Houston, A.C.W., & Rebec, G. V. (2012). Differential effects of cocaine access and withdrawal on GLT1 expression in rat nucleus accumbens core and shell, Neuroscience, 210: 333-339. PMCID: PMC3358423

Hong, S.L., Barton, S.J., & Rebec, G.V. (2012). Neural correlates of unpredictability in behavioral patterns of wild-type and R6/2 mice.  Commun Integr Biol, 5(3):1-3.  PMCID: PMC3419109

Estrada Sánchez, A.M. & Rebec, G.V. (2012). Corticostriatal dysfunction and glutamate transporter 1 (GLT1) in Huntington´s disease:  interactions between neurons and astrocytes.  Basal Ganglia, 2, 57-66. PMCID: PMC3418680

Rebec, G. V. (2012). Cocaine and Amphetamines. In: ELS. John Wiley & Sons, Ltd: Chichester. www.els.net.

Hong, S.L., & Rebec G. V. (2012). A new perspective on behavioral inconsistency and neural noise in aging: Compensatory speeding of neural communication.  Frontiers in Aging Neuroscience, 4 (27): 1-6.  PMCID: PMC3457006

Hong, S. L., Cossyleon, D., Hussain, W. A., Walker, L. J., Barton, S. J. & Rebec, G. V. (2012). Dysfunctional behavioral modulation of corticostriatal communication in the R6/2 mouse model of Huntington’s disease.  PloS One, 7(10): E47026, 1-9.  PMCID: PMC3464283

Hong, S. L., & Rebec, G. V. (2012).  Biological sources of inflexibility in brain and behavior with aging and neurodegenerative diseases.  Frontiers in Systems Neuroscience, 6 (77):1-11. PMID:23226117: PMC3510451  - PubMed

Estrada-Sanchez, A.M. & Rebec, G.V. (2013). Role of cerebral cortex in the neuropathology of Huntington’s disease.  Frontiers in Neural Circuits, Vol. 7, Article 19 (9 pages). PMCID: PMC3575072

Fischer, K.D., Houston, A.C.W., & Rebec, G.V. (2013). Role of the major glutamate transporter GLT1 in nucleus accumbens core vs. shell in cue-induced cocaine seeking behavior.  Journal of Neuroscience, 33:9319-9327.  PMCID: PMC3694387

Rebec, G.V. (2013) Dysregulation of corticostriatal ascorbate release and glutamate uptake in transgenic models of Huntington’s disease.  Antioxidants and Redox Signaling, 2013 May 5. [Epub ahead of print]. 

 

Copyright©The Rebec Group and Indiana University
Questions or Comments: Contact the Webmaster