Lingling Chen

Associate Professor, Biology

Office: Simon Hall 400A

Phone: 812/855-0491

Email: linchen indiana.edu

Education

Ph.D., Stanford University, 1996

Research

Structural and biochemical studies on protein-protein interactions in GroEL-mediated protein folding and microbial communications

Representative Publications

Yali Li, Xinfeng Gao, Lingling Chen. GroEL recognizes an amphipathetic helix and binds to the hydrophobic side, accepted by J. Biol. Chem. 2008

Guozhou Chen, Phillip Jeffery, Clay Fuqua, Yigong Shi and Lingling Chen. Structural basis of TraM anti-activation of quorum sensing transcription factor TraR. Proc. Natl. Acad. Sci. USA, 104:16474-16479, 2007.

Banga, S., Gao, P., Shen, X., Fiscus, V., Zong, W., Chen, L., and Luo, Z. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proc. Natl. Acad. Sci. USA 104:5121-5126, 2007.

Zhida Zheng, Guozhou Chen, Evan D. Brutinel, Timothy L. Yahr, and Lingling Chen. Biochemical characterization of a regulatory cascade controlling transcription of the Pseudomonas aeruginosa type III secretion system. J. Biol. Chem. 282:6136-6142, 2007.

Guozhou Chen, Chao Wang, Clay Fuqua, Lian-Hui Zhang and Lingling Chen. The crystal structure and mechanism of TraM2, a second quorum sensing
antiactivator of Agrobacterium tumefaciens strain A6. J. Bact. 188:8244-8251, 2006.

Lykken, G., Chen, G., Brutinel, E., Chen, L., and Yahr, T. Characterization of ExsC and ExsD self-association and heterocomplex formation. J. Bact. 188:6832-6840, 2006.

Wang, C., Zhang, H.-B., Chen, G., Chen, L, and Zhang, L.-H.. Dual Control of Quorum Sensing by Two TraM-Type Antiactivators in Agrobacterium tumefaciens Octopine Strain A6. Journal of Bacteriology, April 2006, p. 2435-2445, Vol. 188, No. 7

Chen, G., Malenkos, J., Cha, M., Fuqua, C. and Chen, L. 2004. Quorum-Sensing Antiactivator TraM Forms a Dimer That Dissociates to Inhibit TraR. Molecular Microbiology. Mol. Micro. 52: 1641-1651.

Wang J. and Chen L. 2003. Domain motions in GroEL upon binding of an oligopeptide. J Mol Biol. 334(3):489-99.

Chen, L. and Sigler, P. 1999. Crystal structure of a GroEL/peptide complex: Plasticity as a basis for substrate diversity. Cell, 99:757-768.

Chen, L., Wildegger, G., Kiefhaber, T., Hodgson, K. O., and Doniach, S. 1998. Kinetics of lysozyme refolding: Structural characterization of a non-specifically collapsed state using time-resolved X-ray scattering. J. Mol. Biol. 276:225-237.