David Daleke
Associate Professor, Biochemistry and Molecular Biology
Office: Meyers Hall 200B
Phone: 812/855-6902
Email: daleked 
indiana.edu
Education
B.S., Stanford University, 1979
Ph.D. Stanford University, 1986.
American Cancer Society Postdoctoral Fellow, University of California at San Francisco
1986-88; Fellow, Indiana Molecular Biology Institute, 1988
Established Investigator, American Heart Association, 1994-1999
Indiana University School of Medicine Eminent Scholar, 1999
Research
Membrane structure and function; regulation of lipid organization by “flippases” in normal and diabetic blood cells.
Representative Publications
Umakant J. Dumaswala, Michael Wilson, Y. L. Wu, J. Wykle, L. Zhou, L. M. Douglass, and David L. Daleke, "Importance of Red Cell Glutathione and Catalase Against Storage-Induced Free Radical Injury," Free Radical Research (2000) in press.
David L. Daleke and Jill V. Lyles, "Identification and Purification of Phospholipid Flippases," Biochim. Biophys. Acta 1486 (2000) 108-127.
Kayoko Uchida, Kazuo Emoto, David L. Daleke, Keizo Inoue, and Masato Umeda, " Induction of Apoptosis by Phosphatidylserine," Journal of Biochemistry 123 (1998) 1073-1078.
Joanne E. Johnson, Michael L. Zimmerman, David L. Daleke, and Alexandra C. Newton, "Lipid Structure and Not Membrane Structure Is the Major Determinant in the Regulation of Protein Kinase C by Phosphatidylserine," Biochemistry 37 (1998) 12020-12025.
Umakant J. Dumaswala, Michael J. Wilson and David L. Daleke, "Effect of a Glycerol-Containing Hypotonic Medium on Erythrocyte Phospholipid Asymmetry and Aminophospholipid Transport During Storage," Biochim. Biophys. Acta 1330 (1997) 265-273.
Umakant Dumaswala, Michael J. Wilson, Thomas Jose and David L. Daleke. "Glutamine- and Phosphate-Containing Hypotonic Storage Media Better Maintain Erythrocyte Membrane Physical Properties." Blood 88 (1996) 697-704.
Daryl Drummond and David L. Daleke. "Synthesis and Characterization of pH-Dependent "Caged" Aminophospholipids." Chemistry and Physics of Lipids 75 (1995) 27-41.
David L. Daleke, Jill V. Lyles, Edward Nemergut and Michael Zimmerman. "Purification and Substrate Specificity of the Human Erythrocyte Aminophospholipid Transporter." NATO ASI Series H 91 (1995) 49-59.
David L. Daleke, Wray H. Huestis, and Alexandra C. Newton. "Protein Kinase C as a Measure of Transbilayer Phosphatidylserine Asymmetry." Analytical Biochemistry 217 (1994) 33-40.
Michael J. Wilson, Kay Richter-Lowney, and David L. Daleke. "Hyperglycemia Induces a Loss of Phospholipid Asymmetry in Human Erythrocytes" Biochemistry 32 (1993) 11302-11310.
Michael Zimmerman and David L. Daleke. "Regulation of a Candidate Phosphatidylserine-Transporting ATPase by Lipid." Biochemistry 32 (1993) 12257-12263
