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Ken Nephew

Professor

Education

Ph.D., Ohio State University, 1991

Research

DNA methylation in ovarian cancer; breast cancer chemoprevention; spinal cord regeneration; steroid hormone action.

Representative Publications

Ahluwalia A, Yan P, Hurteau JA, Bigsby RM, Jung SH, Huang T, Nephew KP. DNA methylation and ovarian cancer. I: Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization. Gynecol Oncol,82:261-268, 2001.

Ahluwalia A, Hurteau JA, Bigsby RM, Nephew KP. DNA methylation and ovarian cancer. II: Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells. Gynecol Oncol, 82:299-304, 2001.

Fan M, Long X, Bailey JA, Reed CA, Osborne E, Bigsby RM, Nephew KP. The activating enzyme of NEDD8 inhibits steroid receptor function. Mol Endocrinol, 16:315-330, 2002.

Wei S, Chen C, Shi H, Yan P, Harnsomburana J, Shyu C, Nephew KP, Brown R, Huang T. Methylation microarray analysis: late stage ovarian carcinomas distinguish disease-free survival in patients. Clin Cancer Res,8:2246-52, 2002.

Nephew KP, Huang T. Epigenetic gene silencing in cancer initiation and progression. Cancer Lett,190:125-133, 2003.

Fan M, Bigsby RM, Nephew KP. The NEDD8 pathway is required for proteasome mediated degradation of human estrogen receptor-a and essential for the antiproliferation activity of ICI 182,780 in ER-positive breast cancer cells. Mol Endocrinol, 17:356-365, 2003. (cover article)

Shi H, Wei SH, Leu Y-W, Rahmatpanah F, Liu JC, Yan PS, Nephew KP, Huang THM. Triple analysis of the cancer epigenome: an integrated microarray system for assessing gene expression, DNA methylation and histone acetylation. Cancer  Res, 63:2164-2171, 2003. (cover article)

Berry NB, Cho YM, Harrington MA, Foley J, Williams SD, Nephew KP. Transcriptional targeting in ovarian cancer cells using the HE4 promoter. Gynecologic Oncol,92:896-904, 2004.

Fan M, Nakshatri H, Nephew KP.Inhibiting proteasomal proteolysis sustains estrogen receptor-a activation

Mol Endocrinol, 18:2603-15, 2004

Balch C, Huang TH-M, Brown R, Nephew KP.  The epigenetics of ovarian cancer drug resistance and resensitization American Obstet Gynecol, 191:1552-72, 2004

Leu YW, Yan PS, Fan W, Jin VX, Liu CJ, Curran EM, Welshons WV, Wei HS, Davuluri RV, Plass C, Nephew KP, Huang TH-M. Loss of estrogen signaling triggers epigenetic silencing of its downstream targets Cancer Res, 64:8184-8192, 2004

Jin VX, Leu YW, Fan M, Liyanarachchi S, Sun H, Nephew KP, Huang TH-M, Davuluri RV. Identifying estrogen receptor-α target genes using integrated computational genomics and chromatin immunoprecipitation microarray.  Nucleic Acids Res, 32:6627-6635, 2004

Li, L, Shi H, Yiannoutsos C, Huang TH, Nephew KP.  Epigenetic hypothesis tests for methylation and acetylation in a triple microarray system.  J. Computational Biol (in press)

Balch C, Montgomery JS, Paik H-I, Kim SH, Huang T H-M, Nephew KP.  Emerging epigenetic therapies and biomarkers for cancer. Front Biosci (in press)