Martha G. Oakley
Associate Professor, Chemistry Department
Office: Simon Hall 320B
Phone: 812/855-4843
Email: oakley 
indiana.edu
Education
B.A. Carleton College University 1986
B.A. Oxford University 1988.
Ph.D. California Institute of Technology 1994
Research
Bacterial chromosome segregation; coiled coil proteins; phosphoinositide control of protein function; structure-function relationships.
Representative Publications
"The design of antiparallel coiled coils," with J. J. Hollenbeck. Curr. Opin. Struct. Biol., 11, 450 (2001).
"A GCN4 variant with a C-terminal basic region binds to DNA with wild-type affinity," with J. J. Hollenbeck, D. G. Gurnon, G. C. Fazio, and J. J. Carlson. Biochemistry, 40, 13833 (2001).
"Evaluation of the energetic contribution of interhelical coulombic interactions for coiled coil helix orientation specificity," with D. L. McClain and J. P. Binfet. J. Mol. Biol., 313, 371 (2001).
"Design and characterization of a heterodimeric coiled coil that forms exclusively with an antiparallel relative helix orientation," with D. L. McClain and H. L. Woods. J. Am. Chem. Soc., 123, 3151 (2001).
"GCN4 binds with high affinity to DNA sequences containing a single consensus half-site," with J. J. Hollenbeck. Biochemistry, 39, 6380 (2000).
"A buried polar interaction can direct the relative orientation of helices in a coiled coil," with P. S. Kim. Biochemistry, 37, 12603 (1998).
"Protein dissection of the antiparallel coiled coil from Escherichia coli seryl tRNA synthetase," with P. S. Kim. Biochemistry, 36, 2544 (1997).
"Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving," with P. B. Dervan. Science, 248, 847 (1990).
"Synthesis of a hybrid protein containing the iron-binding ligand of bleomycin and the DNA-binding domain of Hin," with K. D. Turnbull and P. B. Dervan. Bioconjugate Chem., 5, 242, (1994).
"Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp," with L. Chen, et al. Current Biol., 5, 882 (1995).
