Craig S. Pikaard
Professor
Office: Myers Hall 300
Phone: 812/855-1874
Email: cpikaard
indiana.edu
Education
Ph.D., Purdue University, 1985
Research
Biochemistry of gene regulation; enzymes of RNA-mediated gene silencing pathways; biochemical analyses of chromatin modifying enzymes; structure and function of plant RNA polymerases IV and V
Representative Publications
Andrzej Wierzbicki, Thomas Ream, Jeremy Haag and Craig S. Pikaard (2009). RNA Polymerase V transcription guides ARGONAUTE4 to chromatin. Nature
Genetics 41:630-634.
Thomas S. Ream, Jeremy R. Haag, Andrzej Wierzbicki, Carrie D. Nicora, Angela Norbeck, Jian-Kang Zhu, Gretchen Hagen, Thomas J. Guilfoyle, Ljiljana Paša-Tolic and Craig S. Pikaard (2008). Subunit compositions of the RNA silencing enzymes, Pol IV and Pol V reveal their origins as specialized forms of RNA Polymerase II. Molecular Cell 33:192-203. Epub 2008 Dec 24.
Preuss, Sasha, Pedro Costa-Nunes, Sarah Tucker, Olga Pontes, Richard J. Lawrence, Rebecca Mosher, Kristin D. Kasschau, James C. Carrington, David C. Baulcombe, Wanda Viegas and Craig S. Pikaard (2008). Multi-megabase silencing in nucleolar dominance involves siRNA-directed DNA methylation and specific methylcytosine binding proteins. Molecular Cell 32:673-684.
Wierzbicki, Andrzej, Jeremy Haag and Craig S. Pikaard (2008). Noncoding transcription by RNA Polymerase Pol IVb/Pol V mediates transcriptional silencing of overlapping and adjacent genes. Cell 135:635-648.
Pontes, Olga, Carey Fei Li, Pedro Costa Nunes, Jeremy Haag, Thomas Ream, Alexa Vitins, Steven E. Jacobsen and Craig S. Pikaard (2006). The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center. Cell 126: 79-92.
Li, Carey F., Olga Pontes, Mahmoud El-Shami, Ian R. Henderson, Yana V. Bernatavichute, Simon W.-L. Chan, Thierry Lagrange, Craig S. Pikaard, and Steven E. Jacobsen (2006). An ARGONAUTE-containing nuclear processing center co-localized with Cajal bodies in Arabidopsis thaliana. Cell 126:93-106.
Earley, Keith, Richard J. Lawrence, Olga Pontes, Rachel Reuther, Angel J. Enciso, Manuela Silva, Nuno Neves, Michael Gross, Wanda Viegas, and Craig S. Pikaard (2006). Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance. Genes & Development 20:1283-1293.
Earley, Keith, Jeremy R. Haag, Olga Pontes, Kristen Opper, Tom Juehne, Keming Song, and Craig S. Pikaard (2006). Gateway-compatible vectors for plant functional genomics and proteomics. The Plant J. 45:616-629
Onodera, Yasuyuki, Jeremy Haag, Thomas Ream, Pedro Costa Nunes, Olga Pontes and Craig S. Pikaard (2005). Plant Nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation. Cell 120:613-62
Lawrence, Richard J., Keith Earley, Olga Pontes, Manuela Silva, Z. Jeffrey Chen, Nuno Neves, Wanda Viegas and Craig S. Pikaard (2004). A concerted DNA methylation/histone methylation switch regulates rRNA gene dosage control and nucleolar dominance. Molecular Cell 13:599-609.
