Michael VanNieuwenhze

Associate Professor, Chemistry Department

Office: Simon Hall 200A

Phone: 812/ 856-7545

Email: mvannieu indiana.edu

Education

B.A. Kalamazoo College 1984
M.S. Yale University 1988
Ph.D. from Indiana University 1992
NIH Postdoctoral Fellow The Scripps Research Institute La Jolla1994

Research

Synthesis and design of antibiotics that inhibit peptidoglycan biosynthesis; bacterial cell wall morphology, synthesis and study of anticancer agents, natural products synthesis.

Representative Publications

Wohlrab, A.; Lamer, R.; VanNieuwenhze, M. S. "Total Synthesis of Plusbacin A3 : A Depsipeptide Antibiotic Active Against Vancomycin-Resistant Bacteria," J. Am. Chem. Soc. 2007 , 129, 4175-4177.

Guzmán-Martínez, A.; Lamer, R.; Narayan; VanNieuwenhze, M. S.* "Total Synthesis of Lysobactin," J. Am. Chem. Soc . 2007, 129 , 6017-6021.

Narayan, R. S.; VanNieuwenhze, M. S. "Synthesis of Substrates and Biochemical Probes for Study of the Peptidoglycan Biosynthetic Pathway, " Eur. J. Org. Chem. 2007, 1399-1414.

Perelman, L. A.; Schwarz, M. P.; Wohlrab, A. VanNieuwenhze, M. S.; Sailor, M. J. "A Simplified Biomolecule Attachment Strategy for Biosensing using a Porous Si Oxide Interferometer," Phys. Stat. Sol. (a) 2007, 204, 1394-1398.

Guzmán-Martínez, A.; VanNieuwenhze, M. S. "An Efficient Synthesis of an Orthogonally-Protected ß-Hydroxyasparagine," Synlett 2007, 1513-1516.

Narayan, R. S.; VanNieuwenhze, M. S. "Versatile and Stereoselective Syntheses of Orthogonally Protected ß-Methylcysteine and ß-Methyllanthionine," Org. Lett. 2005, 7, 2655.

Fahy, E.; Subramaniam, S.; Brown, H. A.; Glass, C. K.; Merrill, Jr, A. H.; Murphy, R. C.; Raetz, C. R. H.; Russell, D. W.; Seyama, Y.; Shaw, W.; Shimizu, T.; Spener, F.; van Meer, G.; VanNieuwenhze, M. S., White, S. H.; Witztum, J. L.; Dennis, E. A. "A Comprehensive Classification System for Lipids," J. Lipid Res. 2005, 46, 839.