Joel Ybe
Assistant Professor
Office: Simon Hall 405B
Phone: 812/856-4882
Email: jybe 
indiana.edu
Education
Ph.D., Rutgers University & University of Medicine and Dentistry of New Jersey, 1991
Postdoctoral Fellow, Princeton University, 1991-1995
Assistant Research Biochemist, University of California San Francisco (UCSF), 1995-2000
Research
Structure and function of Huntingtin-interacting protein 1(HIP1) in clathrin-mediated endocytosis and in the neurodegenerative disorder, Huntington's disease. X-ray crystallography, biochemistry, and mammalian cell systems. Work supported by National Institutes of Health (2R01GM064387-06) (see press releases http://newsinfo.iu.edu/news/page/normal/10731.html and http://newsinfo.iu.edu/news/page/normal/7397.html)Representative Publications
Ybe, J.A., Clegg, M.E., Illingworth, M., Gonzalez, C., and Niu, Q. 2009. Two distantly spaced basic patches in the flexible domain of Huntingtin-Interacting Protein 1 (HIP1) are essential for the binding of clathrin light chain. Research Letters in Biochemistry, doi:10.1155/2009/256124.
Niu, Q., and Ybe, J.A., 2008. Crystal structure at 2.8 Å of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP-protein interactor (HIPPI). J. Mol. Biol., 375, 1197-1205.
Ybe, J.A., Perez-Miller, S., Niu, Q., Coates, D.A., Drazer, M., and Clegg, M.E., 2007. Light chain C-terminal region reinforces the stability of clathrin heavy chain trimers. Traffic 8, 1101-1110.
Ybe, J.A., Mishra, S., Helms, S., and Nix, J., 2007. Crystal structure at 2.8 Å of the DLLRKN containing Coiled-coil Domain of Huntingtin-Interacting Protein 1 (HIP1) Reveals a Surface Suitable for Clathrin Light Chain Binding. J. Mol. Biol. 367, 8-15.
Ybe, J.A., Ruppel, N., Mishra, S., VanHaaften, E., 2003. Contribution of cysteines to clathrin trimerization domain stability and mapping of light chain binding. Traffic 4, 850-856.
Ybe, J.A., Wakeham, D.E., Brodsky, F.M., and Hwang, P.K. 2000. Molecular structures of proteins involved in vesicle fusion.Traffic 1, 474.
Wakeham, D.E., Ybe, J.A., Brodsky, F.M., and Hwang, P.K. 2000. Molecular structures of proteins involved in vesicle coat formation.Traffic 1, 393-398.
Ybe, J.A., Brodsky, F.M., Hofmann, K., Lin, K., Liu, S.H., Chen, L., Earnest, T.N., Fletterick, R.J., and Hwang, P.K. 1999. Clathrin self-assembly is mediated by a tandemly repeated superhelix.Nature 399, 371-375.
Ybe, J.A., Greene, B., Liu, S.H., Pley, U., Parham, P., and Brodsky, F.M. 1998. Clathrin self assembly is regulated by three light-chain residues controlling the formation of critical salt bridges.EMBO J. 17, 1297-1303.
Ybe, J.A. and Hecht, M.H. 1996. Sequence replacements in the central b-turn of plastocyanin.Protein Science 5, 814-824.
