Indiana University
People  |  

Adam ZlotnickAdam Zlotnick

Professor

Office: Simon Hall 220D

Phone: 812/856-1925

Email: azlotnic at indiana.edu

Education

BA, Biology, University of Virginia
PhD, Biology, Purdue University
National Research Council Post-Doctoral Fellow, NIH
Asst. to Full Professor University of Oklahoma Health Sciences Center

Research

Physical and structural basis of virus self-assembly from the perspectives of biological activity, antiviral strategies, and nanotechnology


 Representative Publications

Bourne, C. R., Lee, S., Venkataiah, B., Lee, A., Korba, B., Finn, M.G., Zlotnick, A. (2008) Small-Molecule Effectors of Hepatitis B Virus Capsid Assembly Give Insight Into Virus Lifecycle. J. Virol., in press.

Mukherjee, S., Thorsteinsson, M. V., Johnston, L. B., DePhillips, P. A., Zlotnick, A. (2008) A Quantitative Description of In Vitro Assembly of Human Papillomavirus 16 Virus-like Particles. J. Mol. Biol. 381: 229-37

Bourne, C. R., Finn, M.G., Zlotnick, A. (2006) Global structural changes in hepatitis B capsids induced by the assembly effector HAP1. J. Virol, 80:11055-11061.

Stray, S. J., Kopek, B.G., Johnson, J. M., and Zlotnick, A. (2006) A fluorescence-quenching assay identifies molecules that target hepatitis B virus core assembly. Nature Biotech 24:358-362. (Featured in ACS Chemical Biology and in Nature Reviews – Drug Discovery)

Mukherjee, S., Pfeifer, C., Johnson, J. M., Liu, J., Zlotnick, A. (2006) Redirecting the Coat Protein of a Spherical Virus to Assemble into Tubular Nanostructures. JACS 128:2538-2539. (Featured in Science News)

Johnson, J. M., Tang, J., Nyame, Y., Young, M. J., Zlotnick, A. (2005) Regulating self-assembly of spherical oligomers. Nano Letters 5:765-770.

Stray, S. J., Bourne, C., Punna, S., Lewis, W. G., Finn, M. G., Zlotnick, A. (2005) A heteroaryldihydropyrimidine enhances and can misdirect assembly of hepatitis B Virus capsid. Proc. Nat. Acad. Sci. USA 102:8138-143.

Endres, D., Miyahara, M., Moisant, P., Zlotnick, A. (2005) A reaction landscape identifies the intermediates critical for self-assembly of virus capsids and other polyhedral structures. Protein Science 14:1518-1525. (Cover illustration)

Johnson, J. M., Willits, D. A., Young, M. J., and Zlotnick, A. (2004) Interaction with capsid protein alters RNA structure and the pathway for in vitro assembly of Cowpea Chlorotic Mottle Virus. J. Mol. Biol., 335:455-64.

Zlotnick, A. (2003). Are Weak Protein-Protein Interactions the General Rule in Capsid Assembly? Virology 315:269-274.