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Indiana University Bloomington

Department of Biology

Faculty & Research

Faculty Profile

Eugene Weinberg

Photo of Eugene Weinberg
Professor Emeritus of Biology
Contact Information
By telephone: unlisted phone
no office
Education

Ph.D., University of Chicago, 1950

Awards

1974, Amoco Award for Distinguished Teaching, Indiana University
1978, Fellow, Indiana Academy of Science
1983, President, IU-B Chapter, American Association of University Professors
1983, Two research papers were selected by editor of Benchmark Papers in Microbiology for inclusion in volume 19
1984, Foundation for Microbiology Lecturer, American Society for Microbiology
1986, Traveling Fellow, Victoria (Australia) Society for Microbiology
1988, Inaugural Recipient of the Academic Scientific Achievement Award of the Indiana Branch of the American Society for Microbiology
1989, Indiana University Breneman Lecturer
1995, Indiana University Distinguished Faculty Research Lecturer

Research Description
Principal Research Areas:
  1. Roles of trace metals and phosphate in control of secondary metabolism.
  2. Iron as a notable risk factor for microbial and viral infection, cancer, cardiovascular conditions, arthropathy, osteoporosis, and an extensive array of endocrinological, neurodegenerative and pulmonary diseases. The metal is toxic by catalyzing generation of hydoxyl radicals as well as by serving as a growth-essential nutrient for invading microbial and neoplasmic cells.
  3. Development of iron chelator drugs that might be able to remove toxic iron from specific disease sites.
Area of continuing health education:

Providing current sciencific knowledge (to health care providers and consumers) of methods for prevention of iron loading and of therapy of iron mismanagement.

Introductory text from Dr. Weinberg's 1996 Distinguished Faculty Research Lecture:

Beginning in the 1960s Professor Weinberg was among the first scientists to advance the concept that humans and animals protect themselves from invasion by microbes and cancer cells by withholding iron from the invaders. For over a quarter century he has been at the forefront of his field, assimilating results from many research areas, developing a unified understanding of the data, and opening new areas of investigation. He is praised by his colleagues not only for being one of the first to recognize the relationship between iron and disease but also for nurturing its acceptance by the scientific community during its difficult early years. For years he spoke and wrote whenever possible and to whomever would listen and bore the brunt of criticism, some rather unkind, from those who disagreed.

Professor Weinberg is widely regarded as a rare scientist who is not only brilliant and energetic but who possesses the gift of boldness to see things in new ways. He is respected for his extraordinary ability to propose new models and generate ideas that push back the frontiers of knowledge and open new areas of investigation. Virtually every serious student of host-pathogen interactions recognizes Professor Weinberg's name and has read his papers and heard him speak. He has inspired generations of students and fellow researchers with his enthusiasm, zeal, and creativity and is appreciated for his lucid contributions at symposia and international meetings.

Refereed publications: 200 (60 since retirement in 1992)

Select Publications
Weinberg, E. D.  2008.  Role of iron in osteoporosis.  Pediatric Endocrinology Reviews: 6(Suppl 1)81-85.
Weinberg, E. D. and Miklossy, J.  2008.  Iron withholding: a defense against disease.  Journal of Alzheimer’s Disease 13: 451-463.
Weinberg, E. D.  2007.  Antibiotic properties and applications of lactoferrin.  Current Pharmaceutical Design13: 801-813.
Weinberg, E. D.  2005.  Iron withholding as a defense strategy.  In Anemia of Chronic Disease.  Weisse, G., Gordeuk, V., Hershko, C., (eds.).  M. Dekker, NYC.  Pp. 255-280.
Weinberg, E. D.  2004.  Exposing the hidden dangers of iron.  Cumberland Press, Nashville, TN 305 pp.
Weinberg, G.A., Boelaert J.R., Weinberg E.D.  2002.  Iron and HIV infection.  In: Micronutrients and HIV infection.  Friis, H., (ed.).  CRC Press, Boca Raton, FL.  Pp. 135-158.
Weinberg, E.D. 1999. Monitor iron loading in disease surveillance. Emerging Infectious Diseases 5:346-352.
Weinberg, E.D. 1999.  The development of awareness of the carcinogenic hazard of inhaled iron.  Oncology Research 11:109-113.
Weinberg, E.D.  1996.  The role of iron in cancer.  European Journal of Cancer Prevention 5:19-36.
Weinberg, E.D.  1990.  Cellular iron metabolism in health and disease.  Drug Metabolism Reviews 22:531-579.
Weinberg, E.D.  1984.  Iron withholding: a defense against infection and neoplasia.  Physiol. Rev. 64:65-102.
Weinberg, E.D.  1978.  Iron and infection.  Microbiological Reviews 42:45-66.
Weinberg, E.D.  1974.  Iron and susceptibility to infectious disease.  Science 184:952-956.
Weinberg, E.D.  1970.  Biosynthesis of secondary metabolites: roles of trace metals. Advances in Microbial Physiology 4:1-44.

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