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Indiana University Bloomington

Department of Biology

Faculty & Research

Research Strengths

Chromatin, Chromosomes, and Genome Integrity

We have a strong community of labs in the Department of Biology that focus on various aspect of chromosome biology, including gene function, chromosome replication, chromosome transmission, chromosome structure, and the maintenance of genome integrity. Errors in these processes are associated with developmental abnormalities from plants to humans and can promote cancer. We use a variety of model systems to study these questions including yeast, plants, fruit flies, frogs, mice, and human cells. Interests include defining the mechanisms by which chromosomes are duplicated during S phase of the cell cycle (Calvi, Michaels, Ellison), and how these chromosomes are faithfully segregated to daughter cells during M phase (Zolan, Lacefield, Kaufman, Walczak, Pomerening, Ellison, Mazumdar). Two of our groups study how chromosome segregation is modified and regulated during meiosis (Zolan, Lacefield), an important question relevant to birth defects. We also have a major focus on how “epigenetic” modifications of chromatin regulates the cell cycle (Calvi, Michaels), gene silencing (Pikaard, Michaels, Calvi), and cancer (Mazumdar, Calvi, Nephew). There is significant interaction and exchange of ideas among the labs studying chromosome biology. We also have excellent core facilities to support our research, including state-of-the-art facilities for microscopy, genomics, genetics, and biochemistry. The collaborative community and wonderful facilities make IU Biology a great place to study chromatin, chromosomes, and genome integrity.

Faculty Member Contact Description
Thumbnail photo for Stephen Bell Stephen Bell
Professor

Microbiology
stedbell [at] indiana.edu
812 856 2331
405A Simon Hall
Molecular Biology of the Archaea
Thumbnail photo for Brian Calvi Brian Calvi
Associate Professor of Biology

Genome, Cell & Developmental Biology
bcalvi [at] indiana.edu
812-855-5450
JH 361B
Cell cycle control of DNA replication and genome stability.
Thumbnail photo for Peter Cherbas Peter Cherbas
Emeritus Professor of Biology

Genome, Cell & Developmental Biology
cherbas [at] indiana.edu
812-855-6273
JH A317
Drosophila development and genomics; Nuclear receptors.
Thumbnail photo for Patricia Foster Patricia Foster
Professor of Biology

Microbiology
plfoster [at] indiana.edu
812-855-4084/5-4054(lab)
JH 447E / JH 447A(lab)
Mutagenesis, DNA repair, replication, and recombination.
Thumbnail photo for Peter Hollenhorst Peter Hollenhorst
Adjunct: Assistant Professor, Medical Sciences

pchollen [at] iupui.edu
812-855-1151
JH 209
Mechanisms of transcription factor specificity in cancer.
Thumbnail photo for Heather Hundley Heather Hundley
Adjunct: Assistant Professor, Medical Sciences

hahundle [at] indiana.edu
812-855-0675
JH 213
Post-transcriptional mechanisms of regulating gene expression.
Thumbnail photo for Thom Kaufman Thom Kaufman
Distinguished Professor of Biology

Genome, Cell & Developmental Biology
kaufman [at] indiana.edu
812-855-3033/5-7674(lab)
JH A508 / JH A505 (lab)
Cytogenetics, developmental genetics, and molecular genetics of Drosophila.
Thumbnail photo for Justin Kumar Justin Kumar
Associate Professor of Biology

Genome, Cell & Developmental Biology
jkumar [at] indiana.edu
812-856-2621/6-2702(lab)
MY 202A / MY 202 (lab)
Tissue Specification and Patterning in Drosophila.
Thumbnail photo for Soni Lacefield Soni Lacefield
Assistant Professor of Biology

Genome, Cell & Developmental Biology
sonil [at] indiana.edu
812-856-2429
JH A315B
Mitotic and Meiotic Cell Cycle Regulation
Thumbnail photo for Michael Lynch Michael Lynch
Distinguished Professor of Biology, Class of 1954 Professor

Genome, Cell & Developmental Biology
milynch [at] indiana.edu
812-855-7384/6-0115(lab)
JH 324C / JH 327 (lab)
Evolution; population genetics and genomics; cell biology.
Thumbnail photo for Colin Meiklejohn Colin Meiklejohn
Assistant Scientist

cmeiklej [at] indiana.edu

MY 216B
Thumbnail photo for Scott Michaels Scott Michaels
Professor and Director Center for Genomics & Bioinformatics

Genome, Cell & Developmental Biology
michaels [at] indiana.edu
812-856-0302/6-0355(lab)
MY 316C / MY 359
Regulation of chromatin structure and gene expression by epigenetic modifications.
Thumbnail photo for Craig Pikaard Craig Pikaard
HHMI-GBMF Investigator and Carlos O. Miller Professor

Genome, Cell & Developmental Biology
cpikaard [at] indiana.edu
812-855-1874/5-2659(lab)
MY 300
Mechanisms of RNA-mediated gene silencing and large-scale epigenetic control.
Thumbnail photo for Claire Walczak Claire Walczak
Adjunct: Professor, Medical Sciences

cwalczak [at] indiana.edu
812-855-5919/5-6785(lab)
MY 262 / MY 260 (lab)
Mechanisms of chromosome segregation and aneuploidy; identification of new targets for therapeutic development.
Thumbnail photo for Miriam Zolan Miriam Zolan
Professor of Biology

Genome, Cell & Developmental Biology
mzolan [at] indiana.edu
812-855-6694/5-3692(lab)
JH 217 / 219/221 (lab)
Meiosis and DNA Repair
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