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Indiana University Bloomington

Department of Biology

Faculty & Research

Research Strengths

Developmental Mechanisms and Regulation in Eukaryotic Systems

Developmental geneticists are fascinated by the question of how genetic instructions specify the morphological characteristics that make each species unique. Multicellular eukaryotes as diverse as humans, fruit flies or plants have in common their development from single cells that divide repeatedly in a highly regulated fashion to produce three-dimensional organisms displaying polarity (up versus down; front versus back) and symmetry. Neighboring cells can make differential use of their identical genomic information to form myriad cell types, tissues and organs with complex functions. For cells to achieve their specific fates, thousand of genes must be selectively activated and others must be repressed, with epigenetic chromatin modifications helping maintain the on or off states, depending on developmental and environmental cues. Molecules mediating intercellular signaling, cell-to-cell communication and long-distance transmission of growth signals (e.g. hormones) are also critical for orchestrating developmental processes. The GCDB Program at Indiana University is known for its breadth and depth of expertise in these aspects of modern developmental biology. Using numerous model organisms, and state-of-the art instruments for microscopy, cell sorting, and high-throughput analyses of whole genomes, regulatory RNAs and proteins, researchers within the GCDB program are pursuing answers to some of Biology’s most burning questions.

For more information, please explore the following links:

Faculty Member Contact Description
Thumbnail photo for Brian Calvi Brian Calvi
Associate Professor of Biology

Genome, Cell & Developmental Biology
bcalvi [at] indiana.edu
812-855-5450
JH 361B
Cell cycle control of DNA replication and genome stability.
Thumbnail photo for Peter Cherbas Peter Cherbas
Emeritus Professor of Biology

Genome, Cell & Developmental Biology
cherbas [at] indiana.edu
812-855-6273
JH A317
Drosophila development and genomics; Nuclear receptors.
Thumbnail photo for Christina Dann Christina Dann
Affiliate Asst. Scientist Biology, Asst. Scientist Chemistry Dept.

ctdann [at] indiana.edu
812-855-0821
Myers 216B
Genetic and cellular studies of mouse spermatogonial stem cells.
Thumbnail photo for Roger Hangarter Roger Hangarter
Class of 1968 Chancellor's Professor

Genome, Cell & Developmental Biology
rhangart [at] indiana.edu
812-855-5456/5-2179(lab)
MY 352 / MY 330 (lab)
Plant physiology: environmental sensory-response systems and plant development.
Thumbnail photo for Thom Kaufman Thom Kaufman
Distinguished Professor of Biology

Genome, Cell & Developmental Biology
kaufman [at] indiana.edu
812-855-3033/5-7674(lab)
JH A508 / JH A505 (lab)
Cytogenetics, developmental genetics, and molecular genetics of Drosophila.
Thumbnail photo for Justin Kumar Justin Kumar
Associate Professor of Biology

Genome, Cell & Developmental Biology
jkumar [at] indiana.edu
812-856-2621/6-2702(lab)
MY 202A / MY 202 (lab)
Tissue Specification and Patterning in Drosophila.
Thumbnail photo for Scott Michaels Scott Michaels
Professor and Director Center for Genomics & Bioinformatics

Genome, Cell & Developmental Biology
michaels [at] indiana.edu
812-856-0302/6-0355(lab)
MY 316C / MY 359
Regulation of chromatin structure and gene expression by epigenetic modifications.
Thumbnail photo for Keithanne Mockaitis Keithanne Mockaitis
Associate Scientist

kmockait [at] indiana.edu
812-856-2051
Lab MY 100
Thumbnail photo for John Murray John Murray
Senior Scientist, Hu Lab

murrayjo [at] indiana.edu
812-855-0311
MY 230
Thumbnail photo for Craig Pikaard Craig Pikaard
HHMI-GBMF Investigator and Carlos O. Miller Professor

Genome, Cell & Developmental Biology
cpikaard [at] indiana.edu
812-855-1874/5-2659(lab)
MY 300
Mechanisms of RNA-mediated gene silencing and large-scale epigenetic control.
Thumbnail photo for Joe Pomerening Joe Pomerening
Assistant Professor of Biology

Genome, Cell & Developmental Biology
jpomeren [at] indiana.edu
812-856-3952
SI 043F / SI 043
Signal transduction pathways governing early embryonic and somatic cell cycles, and understanding the integration of feedback loops and other signaling elements in their M-phase control systems.
Thumbnail photo for Elizabeth Raff Elizabeth Raff
Professor of Biology

Genome, Cell & Developmental Biology
raff [at] indiana.edu
812-855-5287
MY 100A
Specification of three-dimensional biological form.
Thumbnail photo for Erik Ragsdale Erik Ragsdale
Assistant Professor of Biology

ejragsda [at] indiana.edu

Evolutionary developmental genetics; developmental plasticity; morphological novelty in nematodes
Thumbnail photo for Nicholas Sokol Nicholas Sokol
Assistant Professor of Biology

Genome, Cell & Developmental Biology
nsokol [at] indiana.edu
812-856-6812/6-4914(lab)
JH A504/JH A502A(lab)
MicroRNA Function in Drosophila.
Thumbnail photo for Jason Tennessen Jason Tennessen
Assistant Professor

jtenness [at] indiana.edu
855-9803 / 856-3616 (lab)
JH 343B / JH 341 (lab)
Studies of cancer metabolism using Drosophila as a model system
Thumbnail photo for Andrew Zelhof Andrew Zelhof
Assistant Professor of Biology

Genome, Cell & Developmental Biology
azelhof [at] indiana.edu
812-855-0294
JH 357A
Photoreceptor cell morphogenesis
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