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Indiana University Bloomington

Department of Biology

Faculty & Research

Research Strengths


We use model systems and human pathogens to contribute to basic and applied research using viruses and their hosts.  The questions can be divided into three broad and overlapping areas:  1) virus structure, 2) viral mechanisms, and 3) pathogenesis.  The systems used include the Hepatitis B virus, Hepatitis C, Papilloma viruses, Brome mosaic virus, Sindbis virus, Reovirus, and several others.

Virus structure.  We use cryoelectron microscopy, crystallography, biochemical and biophysical methods to understand how virus particles assemble and disassemble. The overall goals are to understand how structures affect function, to discover new targets for the design of therapeutics, and to use these basic properties to build better nanotechnology tools.

Viral mechanisms.  We use structural, cell-based, molecular, and biochemical methods to understand genome replication and gene expression, virus entry and spread. These areas will contribute to basic understandings of protein-protein and protein-nucleic acid interactions that are essential to life and the design of new antiviral strategies.

Pathogenesis.   We use biochemical, molecular, and genetic methods to investigate the activation of host pathways controlling cell-death and innate immune responses by viral molecules or viral processes.  These areas will contribute to areas of gene regulation, immunobiology, and the underlying basis for virus-associated and inflammation-associated diseases.

Prospective students please note:  Emeritus faculty generally do not accept new graduate students.

Faculty Member Contact Description
Thumbnail photo for Pranav Danthi Pranav Danthi
Associate Professor of Biology

pdanthi [at]
SI 220B
Reovirus-host interactions.
Thumbnail photo for Richard Hardy Richard Hardy
Professor of Biology, Associate Chair of Teaching

rwhardy [at]
SI 220E / SI 015 (lab)
Genome functions of RNA viruses and the roles of trans-acting factors.
Thumbnail photo for Cheng Kao Cheng Kao
Adjunct: Professor of Biochemistry

ckao [at]
SI 205A
Biochemistry of RNA virus infection and innate immunity.
Thumbnail photo for Tuli Mukhopadhyay Tuli Mukhopadhyay
Associate Professor of Biology

sumukhop [at]
SI 220C / SI 019 (lab)
Structure and assembly of enveloped, RNA viruses.
Thumbnail photo for Milton Taylor Milton Taylor
Professor Emeritus of Biology

taymil [at]
JH 336A
The interferon response in hepatitis C patients. A study using DNA array technology to explain the differences in response to treatment and decrease in viral titer.
Thumbnail photo for Adam Zlotnick Adam Zlotnick
Adjunct: Professor of Biochemistry

azlotnic [at]
SI 220D/SI 217A
Biophysics of virus assembly related to virus biology, development of antiviral strategies, and construction of virus nanostructures.
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