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Indiana University Bloomington

Department of Biology

Faculty & Research

Research Strengths

Virology

We use model systems and human pathogens to contribute to basic and applied research using viruses and their hosts.  The questions can be divided into three broad and overlapping areas:  1) virus structure, 2) viral mechanisms, and 3) pathogenesis.  The systems used include the Hepatitis B virus, Hepatitis C, Papilloma viruses, Brome mosaic virus, Sindbis virus, Reovirus and several others.

Virus structure.  We use cryoelectron microscopy, crystallography, biochemical and biophysical methods to understand how virus particles assemble and disassemble. The overall goals are to understand how structures affect function, to discover new targets for the design of therapeutics, and to use these basic properties to build better nanotechnology tools.

Viral mechanisms.  We use structural, cell-based, molecular, and biochemical methods to understand genome replication and gene expression, virus entry and spread. These areas will contribute to basic understandings of protein-protein and protein-nucleic acid interactions that are essential to life and the design of new antiviral strategies.

Pathogenesis.   We use biochemical, molecular, and genetic methods to investigate the activation of host pathways controlling cell-death and innate immune responses by viral molecules or viral processes.  These areas will contribute to areas of gene regulation, immunobiology, and the underlying basis for virus-associated and inflammation-associated diseases.

Faculty Member Contact Description
Thumbnail photo for Pranav Danthi Pranav Danthi
Assistant Professor of Biology

Microbiology
pdanthi [at] indiana.edu
812-856-2449
SI 220B
Reovirus-host interactions.
Thumbnail photo for Richard Hardy Richard Hardy
Professor of Biology, Associate Chair of Teaching

Microbiology
rwhardy [at] indiana.edu
812-856-0652/6-0649(lab)
SI 220E / SI 015 (lab)
Genome functions of RNA viruses and the roles of trans-acting factors.
Thumbnail photo for Cheng Kao Cheng Kao
Adjunct: Professor of Biochemistry

ckao [at] indiana.edu
812-855-7583
SI 205A
Biochemistry of RNA virus infection and innate immunity.
Thumbnail photo for Tuli Mukhopadhyay Tuli Mukhopadhyay
Associate Professor of Biology

Microbiology
sumukhop [at] indiana.edu
812-856-3686/6-3633(lab)
SI 220C / SI 019 (lab)
Structure and assembly of enveloped, RNA viruses.
Thumbnail photo for Milton Taylor Milton Taylor
Professor Emeritus of Biology

taymil [at] indiana.edu
812-855-3340
SI 220D
The interferon response in hepatitis C patients. A study using DNA array technology to explain the differences in response to treatment and decrease in viral titer.
Thumbnail photo for Adam Zlotnick Adam Zlotnick
Adjunct: Professor of Biochemistry

azlotnic [at] indiana.edu
812-856-1925/6-1874
SI 220D/SI 217A
Biophysics of virus assembly related to virus biology, development of antiviral strategies, and construction of virus nanostructures.
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