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Indiana University Bloomington

Department of Biology

Graduate Studies

Genetics, Cellular & Molecular Sciences Training Grant

Trainee Profile

Ryan Over

Photo of Ryan Over
Research Image(s)
Histone H1 facilitates chromatin compaction and is a key player in regulating and causing local chromatin folding and unfolding.

Figure 1. Histone H1 facilitates chromatin compaction and is a key player in regulating and causing local chromatin folding and unfolding.

Graduate Student
Contact Information
By telephone: 812-856-0355 (lab)
MY 359
Michaels Lab
Program
Molecular and Cellular Biochemistry
Education
Bachelor of Science in Biochemistry, Cum Laude; 2011; University of Rochester, Rochester, NY
Awards
NIH Training Grant in Genetics, Cellular, and Molecular Sciences (2014-2016)
Outstanding Associate Instructor Award, Dept. of Biology, Indiana University (2013)
Floyd Plant and Fungal Biology Summer Fellowship, Indiana University (2013, 2014)
Research Description

Statistically, organisms can be very similar genetically and all cells within a multicellular organism have the same genome. Yet different organisms and cell types have diverse functions and life cycles because their genomes function differently by being packaged differently. My research is focused on understanding how the DNA packaging protein histone H1 (H1) contributes to genome/gene regulation. The basic unit of packaged DNA (chromatin) consists of an octamer of core histones wrapped around ~150 bp of DNA to form the nucleosome. H1 binds DNA between the nucleosomes to further compact DNA, which positions it well to affect and regulate local chromatin structure (Figure 1). DNA methylation and post-translational modifications (PTMs) to histones alter this packaging and their interactions with other packaging proteins. At present, the identity and functions of plant H1 PTMs are unknown. Further, we don't have a good understanding of how H1 participates with other packaging proteins in gene regulation. To get at these questions, I am using a variety of biochemical, microscopy, and genetic techniques. This research will contribute to our understanding of how plants interact with their environments and the similarities and difference between plants and other multicellular organisms. 

Select Publications

Over, R.S. & Michaels, S.D. Open and Closed: The Roles of Linker Histones in Plants and Animals. Molecular Plant 7, 481-91 (2014).


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