- Contact Information
- Contact Ryan Over by email:firstname.lastname@example.org
- By telephone: 812-856-0355 (lab)
- MY 359
- Michaels Lab
- Molecular and Cellular Biochemistry
- Bachelor of Science in Biochemistry, Cum Laude; 2011; University of Rochester, Rochester, NY
- NIH Training Grant in Genetics, Cellular, and Molecular Sciences (2014-2016)
Outstanding Associate Instructor Award, Dept. of Biology, Indiana University (2013)
Floyd Plant and Fungal Biology Summer Fellowship, Indiana University (2013, 2014)
Statistically, organisms can be very similar genetically and all cells within a multicellular organism have the same genome. Yet different organisms and cell types have diverse functions and life cycles because their genomes function differently by being packaged differently. My research is focused on understanding how the DNA packaging protein histone H1 (H1) contributes to genome/gene regulation. The basic unit of packaged DNA (chromatin) consists of an octamer of core histones wrapped around ~150 bp of DNA to form the nucleosome. H1 binds DNA between the nucleosomes to further compact DNA, which positions it well to affect and regulate local chromatin structure (Figure 1). DNA methylation and post-translational modifications (PTMs) to histones alter this packaging and their interactions with other packaging proteins. At present, the identity and functions of plant H1 PTMs are unknown. Further, we don't have a good understanding of how H1 participates with other packaging proteins in gene regulation. To get at these questions, I am using a variety of biochemical, microscopy, and genetic techniques. This research will contribute to our understanding of how plants interact with their environments and the similarities and difference between plants and other multicellular organisms.
Over, R.S. & Michaels, S.D. Open and Closed: The Roles of Linker Histones in Plants and Animals. Molecular Plant 7, 481-91 (2014).