I590 Exercise 1

Subject: Review of SciFinder Scholar

Due: 19 January 2006
Updated: 1 January 2006

In the following exercises, limit your searching to the CA files only (exclude Medline).

1. It is possible to use an existing structure in SciFinder Scholar as the basis for a structure search. Recently, such a strategy was suggested on CHMINF-L in order to find compounds related to the structure for RN 639090-54-3.

Find the compound in SFS, and look at the detailed full record.

Copy the RN in the full record, go to the structure searching component of SFS, and paste it into the window.

Search the compound as a substructure in SFS, and find all references to preparations for them in the CA File. (Get substances, then Get references, limiting the references to those associated with preparation.)

[1] How many references did you find?

Re-run the search in the CASREACT database (Get Reactions) so that substructures of more complex substances are retrieved as products in the reaction.

[2] How many reactions/references did you find?

[3] Why are there less references retrieved in one case compared to the other?

2. Use SFS to find the CAS Index Name (inverted) and Registry Number for the compound Ge-132 (also know as carboxyethylgermanium sesquioxide).

[4] Index Name:

[5] Registry Number:

[6] How many references are associated with this substance in the CA File?

Now try a Research Topic search using all of the four main terms from the name (carboxy ethyl germanium oxide).

[7] How many references were found containing all of those concepts?

[8] Explain why this search resulted in so many fewer references.

Now try the search using the same words in a Substance Identifier search.

[9] How many substances were found?

[10] Was the original substance (Ge-132) among them?

[11] Why did you find it in this search that employed the name fragments, but not the other?

3. Search for rhodium-catalyzed intermolecular allylic etherification, using this phrase exactly in a Research Topic search. Of the two answers retrieved, one has the phrase exactly as typed, but the other does not include all of the words (or a related root word). The term that did not show up in the title of the Organic Letters article is part of the "text modification" of the controlled vocabulary indexing field.

[12] What is the term?

[13] In what inverted index of the CA File could this term be found on STN by using the EXPAND command?

4. T. Ventura-Holman published an article in the journal Genomics in 1998 on the murine Fem1 gene family. Use the option to look for alternative spellings of the last name, and look at the page on which you found her name.

[14] What do you see that is interesting about the order of the candidate names presented?

Try a search for A. Szent Gyorgyi.

[15] How many variants of his name appear on that page that might reasonably be considered to be the publications of the Nobel Prize winner? (Be careful to look up and down!)

5. Search in the Registry File component of SFS for Zinc Finger Protein.

[16] How many entries were found?

Now try the search as a Research Topic.

[17] How many references contained the phrase as entered?

Write down five short designations (e.g., ZNF202) for the various zinc finger proteins that are listed in the titles of the works retrieved.

[18] _______________ _______________ _______________ _______________ _______________

Analyze the supplementary terms, sorting alphabetically, and record the number of times each of your terms was found in that index. (This will take a while; be patient!)

[19] _______________ _______________ _______________ _______________ _______________

Get the references for one of your entries in the alphabetical list.

Get Related entries for those:

6. Repeat your seach for the RN 639090-54-3.

Get all references.

[26] How many did you find?

Try to Get Related using eScience for this search.

[27] If it didn't work, explain why.