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Folding Induced by Proton-Transfer Reactions

Studies of disulfide-reduced lysozyme showed that removal of protons by proton-transfer reagents induced folding. The collision cross sections shown below are connected with lines to indicate possible folding pathways inferred from the proton transfer studies.

Relevant Publications:
Valentine, S. J.; Anderson, J. G.; Ellington, A. D.; Clemmer, D. E. Disulfide-Intact and -Reduced Lysozyme in the Gas Phase: Conformations and Pathways of Folding and Unfolding, J. Phys. Chem. B 1997, 101, 3891-3900.

Last modified:   October 23, 2006