Course Format: Lecture: 11:15A-12:30P, TR, JH A106.

Prerequisites:  A course in genetics or consent of instructor.

Course Description:  Course gives students a complete foundation in the
principle of human genetics.  This field of genetics is perhaps the most
rapidly growing area of biology today.  Course covers the following topics:

- Fundamentals of transmission genetics, pedigree analysis of dominant and
recessive genes inheritance.  Linkage analysis (linkage disequilibrium and
lod score analysis).  Sex linked inheritance, sex influenced and sex
limited inheritance.  Determination of sex in humans.
- Fundamentals of human genome structure.  Gene and chromosome structures.
- Organization and expression of the human genes. Human multigene families.
- Human repetitive DNA, VNTR analysis, mini and microsatelites.  DNA finger
printing.
- Mutation and instability of human DNA.  Chromosomal abnormalities.
- Mapping of the human genome.  Physical mapping, genetic mapping.  Human
Genome Project.
- Human genetic diseases.  Molecular pathology of most common genetic
diseases.  Complex diseases. Genetic testing.
- Gene therapy and novel therapeutic approaches to human genetic abnormalities.
- Genetic of cancer.  Oncogenes and tumor suppressor genes.  Somatic
mutations of human DNA and cancer.
- Genetics of immunity.
- PCR technology as applied to human genome analysis.

Exams/Papers: Three exams and assigned reading of original papers.