Course Format: Lecture: 8:00A-9:15A, TR, JH 239.

Prerequisites: Biol L211.

Course Description:  The goal of this course is to gain an understanding of
the current questions and strategies driving some of the cutting-edge,
cellular/molecular studies relevant to cancer, with emphasis on the control
of the cell cycle and signal transduction.  Toward this goal, we will read
and discuss the following articles (with possible modifications to this
list):
The Hallmarks of Cancer.  2000.  Cell 100:57-68.
Mammalian Ras interacts directly with the Serine/Threonine kinase Raf.
1993.  Cell 74:205-213.
The ins and outs of signalling.  2001.  Nature 411:759-762.
Oncogenic kinase signalling.  2001.  Nature 411:355-364.
Why some leukemia cells resist STI-571.  2001.  Science 292:2231.
G1 phase progression:  Cycling on cue.  1994.  Cell 79:551-554.
Cyclins and cancer II:  Cyclin D and CDK inhibitors come of age.  1994.
Cell 79:573:579.
Evolving ideas about cyclins.  1999.  Cell 98:129-132.
Preventing hair loss from chemotherapy.  2001.  Science 291:25.
Are all cancer genes equal?  2001.  Nature 411:1001-1002.
Cyclin ubiquitination:  The destructive end of mitosis.  1995.  Cell
81:149-151.
Eliminating all obstacles:  Regulated proteolysis in the eukaryotic cell
cycle.  1997.  Cell 91:149-151.
The difficulty in separating sisters.  1999.  Science 285:344-345.
Waiting for anaphase:  Mad2 and the spindle assembly checkpoint.  2000.
Cell 103:997-1000.
p27 destruction:  Cks1 pulls the trigger.  2001.  Nature Cell Biology
3:E95-E98.
Regulating S phase:  CDKs, licensing and proteolysis.  1996.  Cell 85:785-787.
DNA:  Once copied, thrice blocked.  2001.  Science 292:2415, 2417.
Proliferation, cell cycle and apoptosis in cancer.  2001.  Nature 411:342-347.
Splicing into senescence:  The curious case of p16 and p19ARF.  1997.  Cell
91:555-557.
Has the smart bomb been defused?  1998.  Nature 395:13, 15.
Signaling to p53:  Breaking the MDM2-p53 circuit.  1998.  Cell 95:5-8.
Does cancer therapy trigger cell suicide?  1999.  Science 286:2256-2258.
Piecing together the p53 puzzle.  2000.  Science 287:1765-1766.
p53:  Death star.  2000.  Cell 103:691-693.
The biochemistry of apoptosis.  2000.  Nature 407:770-775.
Life and cancer without telomerase.  1997.  Cell 91:1-3.
Telomerase and senescence:  Ending the debate.  1998.  Science 279:334-335.
For better or worse?  Telomerase inhibition and cancer.  1999.  Cell
98:273-275.
Cellular senescence:  Mitotic clock or culture shock?  2000.  Cell 102:407-410.
Benefits of bad telomeres.  2000.  Nature 406:573-574.
When do telomeres matter?  2001.  Science 291:839-840.
Defying death after DNA damage.  2000.  Nature 407:777-782.
A nice ring to the centrosome.  1995.  Nature 378:555-556.
Do centrosome abnormalities lead to cancer?  2001.  Science 292:426-427, 429.
Centrosome duplication:  A centriolar pas de deux.  2001.  Cell 105:417-420.
Motor function in the mitotic spindle.  2000.  Cell 102:399-402.

Required Text: None.  There will be a course packet of the above review
articles, instead.

Weekly Assignments: Formulating questions about each reading.

Exams/Papers: Not sure, yet.  Probably no papers, and maybe no real exams.
May just have a bunch of short quizes/exercises.