Course Format: Lecture: 9:30A-10:45A, TR, JH 440.

Prerequisites: Familiar with basic concepts of microbiology, genetics,
and molecular biology as seen in Biol L211, M310 and M315.

Course Description:  Genetics and molecular genetics of bacteria.
Molecular basis of mutagenesis and DNA repair.  Methods for the
isolation and use of mutations in the analysis of biological processes.
Suppressors.  Transmission of genetic material:  transformation,
conjugation transduction.  Gene mapping.  Transposition.  Homologous
recombination.  Plasmids and their use in molecular genetics.  Gene
fusion.  Restriction-modification.  Cloning. DNA sequencing.  Site-
directed mutagenesis.  Polymerase chain reaction (PCR).  Protein
overproduction.  Current topics section including adaptative mutation,
bacterial differentiation, pathogenesis, antibiotic resistance, and
gene regulation.

Required Text:  "Molecular Genetics of Bacteria" by L. Snyder and W.
Champness. ASM Press.

Weekly Assignments: Reading of research articles, homework, questions
on the articles.

Exams/Papers: Three-four exams (including final), homework.