Our reasearch interests fall under a common umbrella we term the biophysical chemistry of infectious disease. Work is ongoing in three separate projects: 1) transition metal homeostasis (metallostasis) in bacterial pathogens; 2) hydrogen sulfide (H2S) sensing and reactive sulfur species (RSS) in the major nosocomial pathogen, Staphylococcus aureus (MRSA); and 3) the replication of vertebrate coronaviruses, including the causative agent of Middle East Respiratory Syndrome (MERS). Prof. Giedroc seeks a molecular-level understanding of macromolecular structure, dynamics and regulation, and uses the tools of biophysical chemistry, bioinorganic chemistry, proteomic profiling and NMR structure determination.
|Metallostasis in bacterial pathogens|
|Sulfide sensing and reactive sulphur species in Staphylococcus aureus|
|Coronavirus replication: RNA Structure and protein-RNA interactions|
|Ribosomal frameshifting in RNA Viruses|
|Cell division and peptidoglycan remodeling in Streptococcus Pneumoniae|