Our reasearch interests fall under a common umbrella we term the biophysical chemistry of infectious disease. Work is ongoing in three separate projects: 1) transition metal homeostasis (metallostasis) in bacterial pathogens; 2) hydrogen sulfide (H2S) sensing and reactive sulfur species (RSS) in the major nosocomial pathogen, Staphylococcus aureus (MRSA); and 3) the replication of vertebrate coronaviruses, including the causative agent of Middle East Respiratory Syndrome (MERS). Prof. Giedroc seeks a molecular-level understanding of macromolecular structure, dynamics and regulation, and uses the tools of biophysical chemistry, bioinorganic chemistry, proteomic profiling and NMR structure determination.

Metallostasis in bacterial pathogens
Sulfide sensing and reactive sulphur species in Staphylococcus aureus
Coronavirus replication: RNA Structure and protein-RNA interactions

Past Projects

Ribosomal frameshifting in RNA Viruses

Collaborative Projects

Cell division and peptidoglycan remodeling in Streptococcus pneumoniae