Indiana Section of the Society for Applied SpectroscopyIndiana Section of the Society for Applied Spectroscopy
2000-2001 Seminar Abstracts
THE REACTIONS OF MACRO-IONS IN THE GAS-PHASE AND THEIR POTENTIAL ROLES IN ANALYTICAL CHEMISTRY
Scott A. McLuckey
Department
of Chemistry, Purdue University, West Lafayette, Indiana 47907
The formation, manipulation, and analysis of ions derived from macro-molecules present significant challenges and opportunities to analytical chemists. The ability to form gaseous ions from molecules ranging from synthetic polymers to proteins and DNA requires the development of new tools to maximize the range of information that can be obtained from the ions via mass spectrometry. This talk will summarize the development of new tools for characterizing gaseous macro-ions taking place at Purdue University and Oak Ridge National Laboratory using the quadrupole ion trap as the main tool for ion chemistry studies and mass analysis. In this presentation, emphasis will be placed on novel gas-phase ion chemistry and its potential role in addressing important analytical challenges. Particular emphasis will be placed on unimolecular dissociation and the reactions of oppositely-charged ions for charge state manipulation of ions derived from electrospray. Analytical challenges to which these chemistries have been applied included DNA sequencing and the rapid identification of proteins in complex mixtures.
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