In 1954, James N. Shoolery described the first application of Nuclear Magnetic Resonance Spectroscopy (NMR) [Anal. Chem. 26, 1400-1403 (1954)]. Although the detection of nuclear magnetic effects in solid matter was reported eight years earlier by Purcell and coworkers [Phys. Rev. 69, 37 (1946)], the use of NMR as a chemical analysis technique had not been demonstrated. Using “high resolution” spectra, Shoolery demonstrated the utility of NMR for molecular electron distribution studies, structure determinations, organic group identifications, and for studies concerning organic compound structural features. Later, incorporation of Fourier Transform (FT) analysis revolutionized the field of NMR spectroscopy by allowing the simultaneous excitation and detection of multiple frequencies, which greatly enhanced the sensitivity and utility of this technique. Today, FT-NMR is widely employed in numerous chemical and biological applications, including those first described Shoolery.