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Indiana University Bloomington

Faculty from several departments participate in our Graduate Program. They are listed according to the following research area.

students in labs

Carl BauerCarl Bauer

Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 305A

Phone: 812/855-6595

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Lab Website


Ph.D., University of Illinois, 1986
Postdoctoral Fellow, E. I. du Pont de Nemours & Co.


Oxygen and light regulation of gene expression; biosynthesis of heme and chlorophyll; prokaryotic development.

Representative Publications

Shimizu T., Cheng Z., Matsuura K., Masuda S. & C. E. Bauer (2015) The purple bacterium Rubrivivax gelatinosus utilizes altered cis element spacing to promote redox sensing by the photosynthesis gene-specific transcription factor PpsR.  Submitted

Zappa, S & C. E. Bauer (2015)  Regulation of cytochrome biosynthesis.  In Advances in Photosynthesis and Respiration; Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling.  William Cramer and Toivo Kallas (editors). Springer, Dordrecht.  In Press.

Cheng, Z., K. Li, L. A. Hammond, J. A. Karty & C. E. Bauer (2014) B12 controls photosystem gene expression by light regulated binding to the antirepressor AerR. Mol. Microbiol.  91:649-664  NIHMSID 550433  (This work was highlighted in a companion commentary in the same issue by G. Klug.)

Zappa, S. & C. E. Bauer.  (2013) The LysR-Type Transcription Factor HbrL Is A Global Regulator Of Iron Homeostasis And Porphyrin Synthesis In Rhodobacter capsulatus. Mol Microbiology. 90:1277-1292 PMC3875232

Yin, L., V. Dragnea, G. Fieldman, L. A. Hammand, J. A. Karty, C. Dann & C. E. Bauer. (2013) Redox and light control of the heme sensing activity of AppA.  mBio 4: e00563-13

Yin, L, & C. E. Bauer (2013) Controlling The Delicate Balance of Tetrapyrrole BiosynthesisPhil. Trans. Royal. Soc. B. 368 no. 1622 20120253. NIHMSID # 442635

Zappa, S. & C. E. Bauer.  (2013)  Iron homeostasis in the Rhodobacter genus. In Genome Evolution of Photosynthetic Bacteria. Edt. T. J. Beatty. Advances in Botanical Research, 66:289-326. NIHMSID # 442638

Wu, J, V Dragnea & CE Bauer  (2012) Redox Responding Sensor Kinases.  In Two Component Systems in Bacteria. Ed. R Gross and D Beier.  pp 41-56. Horizon Scientific Press.

Wu J, Cheng Z, Reddie K, Carroll K, Hammad LA, Karty JA, & Bauer CE. (2013) RegB kinase activity is repressed by oxidative formation of cysteine sulfenic acidJ. Biol. Chem. 288:4755-4762. PMID: 23306201

Yin, L, V Dragnea, & Bauer CE (2012) PpsR, a regulator of heme and bacteriochlorophyll biosynthesis, is a heme-sensing protein. J. Biol Chem.  287:13850-13858. PMID: 22378778

Cheng, Z, J Wu, A Setterdahl, K Reddie, K Carroll, L A. Hammad, J A Karty & CE Bauer (2012) Activity of the tetrapyrrole regulator CrtJ is controlled by oxidation of a redox active cysteine located in the DNA binding domain.  Mol. Micro. 85:734-746  PMID: PMC3418406

Yuan H, V Dragnea, Q Wu, KH Garner & Bauer CE (2011) Mutational and structural studies of the PixD BLUF output signal that affects light-regulated interactions with PixE. Biochemistry 50:6365-6375 PMID: 21688827

Prokaryotic Differentiation

Dong, Q., Roychowdhury, S., & C. E. Bauer (2015) Mapping the cgra regulon of Rhodospirillum centenum reveals a hierarchal network controlling cyst development.  Submitted

Roychowdhury, R. S., Q. Dong & C. E. Bauer.  (2015) DNA binding properties of a cGMP binding CRP homolog that controls development of metabolically dormant cysts of Rhodospirillum centenum.  Submitted

Dong, Q., & C. E. Bauer (2015) Transcriptome analysis of cyst formation in Rhodospirillum centenum reveals large global changes in expression during cyst development.  BMC Genomics.  In Press

He, K. & C. E. Bauer (2014) Chemosensory signaling that controls bacterial survivalTrends in Microbiology. 22:389-393

He, K., J. M. Marden, E. M. Quardokus & C. E. Bauer (2013) Phosphate Flow between Hybrid Histidine Kinases CheA3 and CheS3 Controls Rhodospirillum centenum Cyst Formation. PLOS Genetics, DOI: 10.1371/journal.pgen.1004002

Marden, JN, JE Berleman, CE Bauer. 2011. Cyclic GMP regulates encystment in Rhodospirillum centenum.  Mol. Micro. 79:600-615 (Commentary of this study in Mol. Micro 79:562-565). PMID: 21214648