Skip to main content
Indiana University Bloomington

Faculty from several departments participate in our Graduate Program. They are listed according to the following research area.

students in labs
Bochman

Carl BauerMatthew L. Bochman

Assistant Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 405B

Phone:

Send Email

Lab Website

Education

B.S., Juniata College, 2003
Ph.D., University of Pittsburgh, 2008
Postdoctoral Fellow, Princeton University, 2009-2013

Research

The maintenance of genomic integrity with a focus on DNA helicases and other factors involved in DNA replication, recombination, and repair; the evolution of DNA helicases.

Representative Publications

Bochman ML, Paeschke K, Chan A, Zakian VA. Hrq1, a Homolog of the Human RecQ4 Helicase, Acts Catalytically and Structurally to Promote Genome Integrity. Cell Rep. 2014 Jan 30; 6(2): 346-356. doi: 10.1016/j.celrep.2013.12.037. PMID: 24440721.

Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature. 2013 May 23;497(7450):458-62. doi: 10.1038/nature12149. Epub 2013 May 8. PMID: 23657261.

Bochman ML, Paeschke K, Zakian VA. DNA secondary structures: stability and function of G-quadruplex structures. Nat Rev Genet. 2012 Nov;13(11):770-80. doi: 10.1038/nrg3296. Epub 2012 Oct 3. Review. PMID: 23032257.

Bochman ML, Judge CP, Zakian VA. The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? Mol Biol Cell. 2011 Jun 15;22(12):1955-9. doi: 10.1091/mbc.E11-01-0045. PMID: 21670310.

Bochman ML, Schwacha A. The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'. Nucleic Acids Res. 2010 Oct;38(18):6078-88. doi: 10.1093/nar/gkq422. Epub 2010 May 19. PMID: 20484375.

Bochman ML, Sabouri N, Zakian VA. Unwinding the functions of the Pif1 family helicases.
DNA Repair (Amst). 2010 Mar 2;9(3):237-49. doi: 10.1016/j.dnarep.2010.01.008. Epub 2010 Jan 25. Review. PMID: 20097624.

Bochman ML, Schwacha A. The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev. 2009 Dec;73(4):652-83. doi: 10.1128/MMBR.00019-09. Review. PMID: 19946136.

Bochman ML, Bell SP, Schwacha A. Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol. 2008 Oct;28(19):5865-73. doi: 10.1128/MCB.00161-08. Epub 2008 Jul 28. PMID: 18662997.

Bochman ML, Schwacha A. The Mcm2-7 complex has in vitro helicase activity. Mol Cell. 2008 Jul 25;31(2):287-93. doi: 10.1016/j.molcel.2008.05.020. PMID: 18657510.

Bochman ML, Schwacha A. Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step. J Biol Chem. 2007 Nov 16;282(46):33795-804. Epub 2007 Sep 25. PMID: 17895243.