Karen Bush
Adjunct Professor, Molecular and Cellular Biochemistry Department, Biology Department
Education
Ph.D., Indiana University, 1970
Postdoctoral Fellow, University of California, Santa Barbara
Research
Antibiotic resistance in multidrug-resistant Gram-negative bacteria, susceptibility profiles of new antibiotics.
Representative Publications
Antibiotic Resistance
Bush, K. and J. F. Fisher. 2011. Epidemiological expansion, structural studies, and clinical challenges of new b-lactamases from Gram-negative bacteria. Annual Reviews Microbiology. 65:455-478.
Bush, K., P. Courvalin, G. Dantas, J. Davies, B. Eisenstein, P. Huovinen, G. A. Jacoby, R. Kishony, B. N. Kreiswirth, E. Kutter, S. A. Lerner, S. Levy, K. Lewis, O. Lomovskaya, J. H. Miller, S. Mobashery, L. J. V. Piddock, S. Projan, C. M. Thomas, A. Tomasz, P. M. Tulkens, T. R. Walsh, J. D. Watson, J. Witkowski, W. Witte, G. Wright, P. Yeh, and H. I. Zgurskaya. 2011. Tackling antibiotic resistance. Nature Reviews Microbiology. 9:894-896.
Santoro, C. M., K. Bush, and D. Abbanat. 2010. Characterisation of Staphylococcus aureus and Enterococcus faecalis mutants with reduced susceptibility to the investigational oxazolidinone RWJ-416457. International Journal Antimicrobial Agents. 36:424-429.
Queenan, A. M., W. Shang, K. Bush, and R. K. Flamm. 2010. Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. Antimicrobial Agents & Chemotherapy. 54: 4092–4097.
Bush, K. and G. A. Jacoby. 2010. An updated functional classification of beta-lactamases. Antimicrobial Agents & Chemotherapy. 54:969-976.
Queenan, A. M., W. Shang, P. Schreckenberger, K. Lolans, K. Bush, and J. Quinn. 2006. SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing b-lactamases. Antimicrobial Agents & Chemotherapy. 50:3485-3487.
Robicsek A., J. Strahilevitz,. G. A. Jacoby, M. Macielag, D. Abbanat, C. H. Park, K. Bush, and D. C. Hooper. 2006. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nature Medicine. 12:83-88.
New drug development
Bush, K. and M. Pucci. 2011. New antimicrobial agents on the horizon. Biochemical Pharmacology. 82:1528-1539.
Morrow B. J., W. He, K. M. Amsler, B. D. Foleno, M. J. Macielag, A. S. Lynch, and K. Bush. 2010. In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. Antimicrobial Agents & Chemotherapy. 54:1955-1964.
Roll, D. M., Y. Yang, M. J. Wildey, K. Bush and M. D Lee. 2010. Inhibition of metallo-beta-lactamases by pyridine monothiocarboxylic acid analogs. Journal of Antibiotics. 63: 255-257.
Baum, E. Z., S. M. Crespo-Carbone, B. D. Foleno, L. D. Simon, J. Guillemont, M. Macielag and K. Bush. 2009. MurF inhibitors with antibacterial activity: effect on muropeptide levels. Antimicrobial Agents & Chemotherapy. 53:3240-3247.
Davies, T.A., M. G. P. Page, W. Shang, M. Kania, and K. Bush. 2007. Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. Antimicrobial Agents & Chemotherapy. 51: 2621-2624
