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Indiana University Bloomington

Faculty from several departments participate in our Graduate Program. They are listed according to the following research area.

students in labs

Karen BushKaren Bush

Adjunct Professor, Molecular and Cellular Biochemistry Department, Biology Department

Office: JH A311

Phone: 812/855-1542

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Education

Ph.D., Indiana University, 1970
Postdoctoral Fellow, University of California, Santa Barbara

Research

Antibiotic resistance in multidrug-resistant Gram-negative bacteria, susceptibility profiles of new antibiotics.

Representative Publications

Antibiotic Resistance
Bush, K. and J. F. Fisher. 2011. Epidemiological expansion, structural studies, and clinical challenges of new b-lactamases from Gram-negative bacteria. Annual Reviews Microbiology. 65:455-478.

Bush, K., P. Courvalin, G. Dantas, J. Davies, B. Eisenstein, P. Huovinen, G. A. Jacoby, R. Kishony, B. N. Kreiswirth, E. Kutter, S. A. Lerner, S. Levy, K. Lewis, O. Lomovskaya, J. H. Miller, S. Mobashery, L. J. V. Piddock, S. Projan, C. M. Thomas, A. Tomasz, P. M. Tulkens, T. R. Walsh, J. D. Watson, J. Witkowski, W. Witte, G. Wright, P. Yeh, and H. I. Zgurskaya. 2011. Tackling antibiotic resistance. Nature Reviews Microbiology. 9:894-896.

Santoro, C. M., K. Bush, and D. Abbanat. 2010. Characterisation of Staphylococcus aureus and Enterococcus faecalis mutants with reduced susceptibility to the investigational oxazolidinone RWJ-416457. International Journal Antimicrobial Agents. 36:424-429.

Queenan, A. M., W. Shang, K. Bush, and R. K. Flamm. 2010. Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole. Antimicrobial Agents & Chemotherapy. 54: 4092–4097.

Bush, K. and G. A. Jacoby. 2010. An updated functional classification of beta-lactamases. Antimicrobial Agents & Chemotherapy. 54:969-976.

Queenan, A. M., W. Shang, P. Schreckenberger, K. Lolans, K. Bush, and J. Quinn. 2006. SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing b-lactamases. Antimicrobial Agents & Chemotherapy. 50:3485-3487.

Robicsek A., J. Strahilevitz,. G. A. Jacoby, M. Macielag, D. Abbanat, C. H. Park, K. Bush, and D. C. Hooper. 2006. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nature Medicine. 12:83-88.

New drug development
Bush, K. and M. Pucci. 2011. New antimicrobial agents on the horizon. Biochemical Pharmacology. 82:1528-1539.

Morrow B. J., W. He, K. M. Amsler, B. D. Foleno, M. J. Macielag, A. S. Lynch, and K. Bush. 2010. In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. Antimicrobial Agents & Chemotherapy. 54:1955-1964.

Roll, D. M., Y. Yang, M. J. Wildey, K. Bush and M. D Lee. 2010. Inhibition of metallo-beta-lactamases by pyridine monothiocarboxylic acid analogs. Journal of Antibiotics. 63: 255-257.

Baum, E. Z., S. M. Crespo-Carbone, B. D. Foleno, L. D. Simon, J. Guillemont, M. Macielag and K. Bush. 2009. MurF inhibitors with antibacterial activity: effect on muropeptide levels. Antimicrobial Agents & Chemotherapy. 53:3240-3247.

Davies, T.A., M. G. P. Page, W. Shang, M. Kania, and K. Bush. 2007. Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. Antimicrobial Agents & Chemotherapy. 51: 2621-2624