Erin E. Carlson
Assistant Professor, Department of Chemistry
Education
B.A. 2000 St. Olaf College
Ph.D 2005 University of Wisconsin - Madison
Postdoctoral Fellowship 2008 The Scripps Research Institute
Research
Professor Carlson's research program focuses on the development and application of new technologies to explore the mechanisms of bacterial pathogenesis and identify potential therapeutic agents. To accomplish these goals, we work at the interface of chemistry and biology using techniques ranging from organic synthesis to mass spectrometry-based systems biology methods. In particular, we are pursuing the development of new technologies for natural product discovery including innovative methods for compound isolation, screening, and diversification. We are also utilizing state of the art metabolomic and proteomic methods to map the biochemical pathways associated with bacterial pathogenesis and antibiotic resistance.
Representative Publications
Kocaoglu, O.; Calvo, R. A.; Sham, L. T.; Cozy, L. M.*; Lanning, B. R.*; Francis, S.; Winkler, M. E.; Kearns, D. B.; Carlson, E. E. Selective Penicillin-Binding Protein Imaging Probes Reveal Substructure in Bacterial Cell Division. ACS Chem. Biol. DOI: 10.1021/cb300329r.
Wilke, K. E.; Francis, S.; Carlson, E. E. Activity-Based Probe for Histidine Kinase Signaling. J. Am. Chem. Soc. 2012, 134, 9150–9153. Highlighted in: J. Am. Chem. Soc. 2012, 134, 10715-10716.
Trader, D. J. and Carlson, E. E. Chemoselective Hydroxyl Group Transformation: An Elusive Target. Mol. BioSyst. 2012, 8, 2484-2493. Invited Review in Emerging Investigators Themed Issue. Selected as Molecular BioSystems HOT Article and highlighted on their blog, http://blogs.rsc.org/mb/ (7/17/2012).
Odendaal, A. Y.; Garber, K. C. A.; Carlson, E. E. Plant Pigment Identification: A Classroom and Outreach Activity. In Review.
Trader, D. J.; Carlson, E. E. Siloxyl Ether Functionalized Resins for Chemoselective Enrichment of Carboxylic Acids. Org. Lett. 2011, 13, 5652-5655.
Odendaal, A. Y*.; Trader, D. J*.; Carlson, E. E. Chemoselective enrichment for natural products discovery. Chem. Sci. 2011, 2, 760-764. Highlighted in: Chem. & Eng. News, 2011, 89, Feb 14, 34-35 and Chemistry World (http://www.rsc.org/chemistryworld/News/2011/February/15021101.asp).
Carlson, E. E. Mass spectrometry for systems-level biological analysis. Nat. Chem. Bio. 2010, DOI: 10.1038/nchembio.490. Invited Primer.
Carlson, E. E. Natural Products as Chemical Probes. ACS Chem. Biol. 2010, 5, 639-653. Invited Review.
Garber, K. C. A.; Wangkanont, K.; Carlson E. E.; Kiessling, L. L. A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN. Chem. Commun. 2010, 46, 6747-6749.
Carlson, E. E. and Cravatt, B. F. Enrichment Tags for Enhanced-Resolution Profiling of Hydrophilic Metabolites. J. Am. Chem. Soc. 2007 , 129, 15780-15782.
Carlson, E. E. and Cravatt, B. F. Chemoselective Probes for Metabolite Enrichment and Profiling. Nat. Methods, 2007 , 4, 429-435.
Carlson, E. E.; May, J. F.; Kiessling, L. L. Chemical Probes of UDP-Galactopyranose Mutase. Chem. Biol. 2006, 13, 825-837.
Soltero-Higgin, M.; Carlson E. E.; Phillips, J. H.; Kiessling, L. L. Identification of Inhibitors for UDP-Galactopyranose Mutase. J. Am. Chem. Soc. 2004, 126, 10532-10533.
Soltero-Higgin, M.; Carlson, E. E.; Gruber, T. D.; Kiessling, L. L. A Unique Catalytic Mechanism for UDP-Galactopyranose Mutase. Nat. Struc. Mol. Biol. 2004, 11, 539-543.
Carlson, E. E. and Kiessling, L. L. Improved Chemical Syntheses of 1- and 5-Deazariboflavin. J. Org. Chem. 2004, 69, 2614-2617.
