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Indiana University Bloomington

Faculty from several departments participate in our Graduate Program. They are listed according to the following research area.

students in labs

Lingling ChenLingling Chen

Associate Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 400A

Phone: 812/855-0491

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Lab Website

Education

B.S. (1988) Xiamen University - Physical Chemistry
Ph.D. (1996) Stanford University - Chemistry
Helen Hay Postdoctoral Fellow (1997-2000) Yale University - Protein Crystallography

Research

Mechanistic understanding of molecular chaperone functions and bacterial infections.

Representative Publications

Zhida Zheng, Clay Fuqua, and Lingling Chen. The binding site of DNA on quorum-sensing transcript factor TraR does not overlap with that of the Anti-Activator. Biochem. Biophys. Res. Commun. 418:396-401, 2012

Zhida Zheng, Dejian Ma, Timothy Yahr, and Lingling Chen. The Transiently Ordered Regions in Intrinsically Disordered ExsE Are Correlated with Structural Elements Involved in Chaperone Binding. Biochem. Biophys. Res. Commun. 417: 129-134, 2012

Melissa Illingworth, Andrew Ramsey, Zhida Zheng, and Lingling Chen. Stimulating the substrate folding activity of a single-ring GroEL variant by modulating the cochaperonin GroES. J. Biol. Chem. 286: 30401-8, 2011

Yi Pan, Valena Fiscus, Wuyi Meng, Zhida Zheng, Lianhui Zhang, Clay Fuqua, and Lingling Chen. The Agobacterium tumefaciens Transcriptional Factor BlcR Is Regulated via Oligomerization. J. Biol. Chem. 286: 20431-40, 2011

Mair Churchill and Lingling Chen. Structural Basis of Acyl-homoserine Lactone-Dependent Signaling. Chem. Rev. 111: 68-85, 2011

Lingling Chen. Signal Synthesis for a Rapid Response. Structure, 18: 1072-1073, 2010

Yali Li, Zhida Zheng, Andrew Ramsey, and Lingling Chen. Analysis of Peptides and Proteins in Their Binding to GroEL, J. Pept. Sci. 12: 693-700, 2010

Yali Li, Xinfeng Gao and Lingling Chen. GroEL Recognizes an Amphipathetic Helix and Binds to the Hydrophobic Side. J. Biol. Chem. 284: 4324-4331, 2009

Guozhou Chen, Phillip Jeffery, Clay Fuqua, Yigong Shi and Lingling Chen. Structural basis of TraM anti-activation of quorum sensing transcription factor TraR. Proc. Natl. Acad. Sci. USA, 104:16474-16479, 2007

Simran Banga, Ping Gao, Xihui Shen, Valena Fiscus, Wei-Xing Zong, Lingling Chen, and Zhao-Qing Luo. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proc. Natl. Acad. Sci. USA 104:5121-5126, 2007

Zhida Zheng, Guozhou Chen, Evan D. Brutinel, Timothy L. Yahr, and Lingling Chen. Biochemical characterization of a regulatory cascade controlling transcription of the Pseudomonas aeruginosa type III secretion system. J. Biol. Chem. 282:6136-6142, 2007

Guozhou Chen, Chao Wang, Clay Fuqua, Lian-Hui Zhang and Lingling Chen. The crystal structure and mechanism of TraM2, a second quorum sensing antiactivator of Agrobacterium tumefaciens strain A6. J. Bact. 188:8244-8251, 2006

Guinevere Lykken, Guozhou Chen, Evan Brutinel, Lingling Chen, and Timothy Yahr. Characterization of ExsC and ExsD self-association and heterocomplex formation. J. Bact. 188:6832-6840, 2006

Chao Wang, Hai-Bao Zhang, Guozhou Chen, Lingling Chen and Lian-Hui Zhang. Dual control of quorum sensing by two TraM-type antiactivators in Agrobacterium tumefaciens octopine strain A6. J. Bact. 188, 2435-2445, 2006

Guozhou Chen, James Malenkos, Mee-Rye Cha, Clay Fuqua and Lingling Chen. Quorum-sensing antiactivator TraM forms a dimer that dissociates to inhibit TraR. Mol. Micro. 52:1641-1651, 2004

Jiming Wang and Lingling Chen. Domain motions in GroEL upon binding of an oligopeptide. J. Mol. Biol. 334:489-499, 2003

Lingling Chen and Paul Sigler. Crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity. Cell 99:757-768, 1999

Lingling Chen, Gudrun Wildegger, Thomas Kiefhaber, Keith O. Hodgson and Sebastian Doniach. Kinetics of lysozyme refolding: structural characterization of a non-specifically collapsed state using time-resolved x-ray scattering. J. Mol. Biol. 276:225-237, 1998

Lingling Chen, Keith O. Hodgson and Sebastian Doniach. A lysozyme folding intermediate revealed by solution x-ray scattering. J. Mol. Biol. 261:658-671, 1996

Sigurd M. Wilbanks*, Lingling Chen*, David B. McKay, Hirotsugu Tsuruta, and Keith O. Hodgson. Solution Small-angle X-ray Scattering Study of A Bovine Heat-Shock Cognate and Its Subfragments. Biochemistry 34:12095-12106, 1995. (*these two authors contributed equally to this work)

Lingling Chen, Narasaiah Gavini, Hirotsugu Tsuruta, David Eliezer, Barbara K. Burgess, Sebastian Doniach, and Keith O. Hodgson. MgATP-induced conformational changes in the iron protein from Azotobactor vinelandii, as studied by small angle x-ray scattering. J. Bio. Chem. 269:3290-3294, 1994

Weizheng Weng, Jiyang Yan, Jungxiu Cai, Shenjun Dai, Shoujing Cao, Lingling Chen, and Huilin Wan. Chemical trapping and DRFTIR study of mechanism of by-products formation in selective (Amm) oxidation of propylene on MoO3 and g-Bi2MoO6. Chemical Journal of Chinese Universities 12:106-110, 1991