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Indiana University Bloomington

Faculty from several departments participate in our Graduate Program. They are listed according to the following research area.

students in labs

Charles E. Dann IIICharles E. Dann III

Associate Professor, Chemistry

Office: Simon Hall 320D

Phone: 812/856-1704

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B.S., ACS Chemistry Millsaps College 1996.
Ph.D. Biophysics & Biophysical Chemistry Johns Hopkins University
Postdoctoral Fellow University of Texas Southwestern Medical Center 2002


Protein structure-based drug design targeting cells involved in epithelial cancer and autoinflammatory disease. Biochemical, mechanistic, and X-ray crystallographic analyses of regulatory RNAs; developing riboswitch-based molecular sensors.

Representative Publications

Gao X, Dong X, Subramanian S, Matthews PM, Cooper CA, Kearns DB, Dann CE 3rd. Engineered Bacillus subtilis strains allow rapid characterization of heterologous diguanylate cyclases and phosphodiesterases. Appl Environ Microbiol. 2014 Oct; 80(19), 6167-74.
Epub 1 August 2014.

Chang F-MJ, Coyne HJ, Cubillas-Ramirez CA, Fleischmann PV, Fang X, Ma Z, Ma D, Helmann JD, Garcia-de los Santos A, Wang Y-X, Dann CE 3rd, Giedroc DP. Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR). J Biol Chem. 2014 Jul 4; 289(27):19204-19217.Epub 2014 May 15 doi:10.1074/jbc.M114.552380.

Yin L, Dragnea V, Feldman G, Hammad LA, Karty JA, Dann CE 3rd, Bauer CE. Redox and light control the heme-sensing activity of AppA. MBio. 2013 Aug 27;4(5):e00563-13. doi: 10.1128/mBio.00563-13. PubMed PMID: 23982072; PubMed Central PMCID: PMC3760249.

Gao X, Mukherjee S, Matthews PM, Hammad LA, Kearns DB, Dann CE 3rd. Functional Characterization of Core Components of the Bacillus subtilis Cyclic-Di-GMP Signaling Pathway. J Bacteriol. 2013 Nov;195(21):4782-92. doi: 10.1128/JB.00373-13. Epub 2013 Jul 26. PubMed PMID: 23893111.

Wibowo AS, Singh M, Reeder KM, Carter JJ, Kovach AR, Meng W, Ratnam M, Zhang F, Dann CE 3rd. Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15180-8. doi: 10.1073/pnas.1308827110. Epub 2013 Aug 9. PubMed PMID: 23934049; PubMed Central PMCID: PMC3780903.

Fu Y, Tsui HC, Bruce KE, Sham LT, Higgins KA, Lisher JP, Kazmierczak KM, Maroney MJ, Dann CE 3rd, Winkler ME, Giedroc DP. A new structural paradigm in copper resistance in Streptococcus pneumoniae. Nat Chem Biol. 2013 Mar;9(3):177-83. doi: 10.1038/nchembio.1168. Epub 2013 Jan 27. PubMed PMID: 23354287; PubMed Central PMCID: PMC3578076.

Campanello GC, Ma Z, Grossoehme NE, Guerra AJ, Ward BP, Dimarchi RD, Ye Y, Dann CE 3rd, Giedroc DP. Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family. J Mol Biol. 2013 Apr 12;425(7):1143-57. doi: 10.1016/j.jmb.2013.01.018. Epub 2013 Jan 23. PubMed PMID: 23353829; PubMed Central PMCID: PMC3602352.

Gwon AR, Park JS, Arumugam TV, Kwon YK, Chan SL, Kim SH, Yang S, Yun YK, Choi Y, Kim S, Tang SC, Hyun DH, Cheng A, Dann CE 3rd, Bernier M, Lee J, Markesbery WR, Mattson MP, Jo DG. Oxidative lipid modification of nicastrin enhances amyloidogenic y-secretase activity in Alzheimer’s disease, Aging Cell 11(4), 559-68, 2012. doi: 10.1111/j.1474-9726.2012.00817.x

Guerra AG, Dann CE 3rd, Giedroc DP. Crystal Structure of the Zinc-Dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-Bound State, J Am Chem Soc 133(49), 19614-7, 2011. doi: 10.1021/ja2080532

Dann CE 3rd. RNA structure: Riboswitch strikes a chord, Nat Chem Biol 7(10), 660-1, 2011. doi: 10.1038/nchembio.672

Packianathan C, Katen SP, Dann CE 3rd, Zlotnick A. Conformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus Assembly, J Virology 84:3, 1607-15, 2010. doi: 10.1128/JVI.02033-09

Grossoehme NE, Li L, Keane SC, Liu P, Dann CE 3rd, Leibowitz JL, and Giedroc DP. Coronavirus N protein N-terminal domain (NTD) specifically binds the transcriptional regulatory sequence (TRS) and melts TRS-cTRS RNA duplexes, J Mol Biol 394, 544-557, 2009. doi: 10.1016/j.jmb.2009.09.040

Wakeman CA, Winkler WC, Dann CE 3rd. Structural Features of Metabolite-Sensing Riboswitches. Trends Biochem Sci 32:9, 415-24, 2007.

Dann CE 3rd*, Wakeman CA*, Sieling CL, Baker SC, Irnov I, Winkler WC. Structure and Mechanism of a Metal-Sensing Regulatory RNA. Cell 130:5, 878-92, 2007.

Dann CE 3rd, Winkler WC. RNA allostery glimpsed. Nat Struct Mol Biol 13:7, 569-71, 2006 (News and Views).

Dann CE 3rd, Bruick RK. Dioxygenases as O2-dependent regulators of the hypoxic response pathway. Biochem Biophys Res Commun 338:1, 639-47, 2005 (review).

Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE 3rd, Sudhof T, Yu G. Nicastrin functions as a gamma-secretase-substrate receptor. Cell 122:3, 435-47, 2005.

Hamaoka B, Dann CE 3rd, Geisbrecht BV, Leahy DJ. Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA 2A. Proc Natl Acad Sci U S A 101:32, 11673-11678, 2004.

Dann CE 3rd, Bruick RK, Deisenhofer J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci U S A 99:24, 15351-6, 2002.

Ooi SL, Dann C 3rd, Nam K, Leahy DJ, Dahma MJ, Boeke JD. Ribonucleases, Part A: Functional Roles and Mechanisms of Action. “RNA lariat debranching enzyme.” Methods in Enzymology 341,2001.

Dann CE 3rd, Hsieh JC, Rattner A, Sharma D, Nathans J. Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412, 86-90, 2001.

Leahy DJ, Dann CE 3rd, Longo P, Perman B, Ramyar K. A mammalian expression vector for expression and purification of secreted proteins for structural studies. Protein Expression and Purification 20:3, 500-506, 2000.