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Indiana University Bloomington

Faculty from several departments participate in our Graduate Program. They are listed according to the following research area.

students in labs

Jim DrummondJim Drummond

Associate Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 305C

Phone: 812/856-4184

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Education

Ph.D., University of Michigan, 1993

Research

Limited alphabet coding sequences and proteins: a minimalist approach to structure and function.

Representative Publications

D.S. Maillet, B. Schmidt and J.T. Drummond.  A hypothesis for the extrachromosomal origin of coding sequences, in preparation (2007).

D.S. Maillet and J.T. Drummond.  Synthesis and characterization of libraries of open reading frames and proteins comprising severely limited and patterned alphabets, in preparation (2006/2007). 

D.S. Maillet and J.T. Drummond.  Combinatorial synthesis of novel open reading frames from limited codon sets reveals, in revision (2006). 

Larson, E. D., Iams K., and Drummond, J.T. (2003) DNA Repair, 2(11): 1199-210.   Strand-specific processing of 8-oxoguanine by the human mismatch repair pathway: inefficient removal of 8-oxoguanine paired with adenine or cytosine.

Wang, H., Yang, Y., Schofield, M.J., Du, C., Fridman, Y., Lee, D., Larson, E.D., Drummond, J.T., Alani, E., Hsieh, P., and Erie, D.A. (2003) Proceedings of the National Academy of Sciences , 100(25): 14822-7. DNA bending and unbending by MutS govern mismatch recognition and specificity.

Larson, E. D. Nickens, D., and Drummond, J.T. (2002) Nucleic Acids Research , 30(3): E14.   Construction and characterization of mismatch-containing circular DNA molecules competent for assessment of nick-directed human mismatch repair in vitro .

Iams, K., Larson, E.D., and Drummond, J.T. (2002) Journal of Biological Chemistry , 277(34): 30805-14. DNA template requirements for the human mismatch repair pathway in vitro .

Larson, E. D. and Drummond, J.T. (2001) Journal of Biological Chemistry , 276(13), 9775-9783.   Human mismatch repair and G*T mismatch binding by hMutS a in vitro is inhibited by adriamycin, actinomycin D and nogalamycin.

Drummond J.T. and Bellacosa A. (2001) Nucleic Acids Research , 29(11) 2234-2243.   Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites.