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Indiana University Bloomington

Faculty from several departments participate in our Graduate Program. They are listed according to the following research area.

students in labs

David GiedrocDavid P. Giedroc

Professor, Chemistry

Office:Simon Hall 320A

Phone: 812/856-5449

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Lab Website

Education

Ph.D. Biochemistry Vanderbilt University 1984
NIH postdoctoral fellow 1984-1988 Yale University 

Research

Metal sensor proteins in pathogenic bacteria; NMR structural studies of regulatory RNAs in mammalian RNA viruses

Representative Publications

iu, P., Li, L., Millership, J. J., Leibowitz, J. L., & GIEDROC, D. P. (2007) A U-turn motif-containing stem-loop in the coronavirus 5' untranslated region (UTR) plays a functional role in replication. RNA 13, 763-780.

Liu, T., Ramesh, A., Ma, Z, Ward, S. K., Zhang, L., George, G. N., Talaat, A. M., Sacchettini, J. C., & GIEDROC, D. P. (2007) CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator. Nature Chem. Biol. 3, 60-68.

Cornish, P. V., Stammler, S. N. & GIEDROC, D. P. (2006) The global structures of a wild-type and poorly functional plant luteoviral mRNA pseudoknot are essentially identical. RNA 12, 1959-1969.

Cornish, P. V. & GIEDROC, D. P. (2006) Pairwise coupling analysis of helical junction hydrogen bonding interactions in luteoviral RNA pseudoknots. Biochemistry 45, 11162-11171.

Cornish, P. V. GIEDROC, D. P. & Hennig, M. (2006) Dissecting non-canonical interactions in frameshift-stimulating mRNA pseudoknots. J. Biomol. NMR 35, 209-223.

Lee, S., Arunkumar, A.I., Chen, X., & GIEDROC, D. P. (2006) Structural Insights into Homo- and Heterotropic Allosteric Coupling in the Zinc Sensor S. aureus CzrA from Covalently Fused Dimers. J. Am. Chem. Soc. 128, 1937-1947.

Pennella, M.A., Arunkumar, A.I., & GIEDROC, D. P. (2006) Individual Metal Ligands Play Distinct Functional Roles in the Zinc Sensor Staphylococcus aureus CzrA. J. Mol. Biol. 356, 1124-1136.

Cornish, P.V., Hennig, M., & GIEDROC, D. P. (2005) A Loop 2 Cytidine-Stem 1 Minor Groove Interaction as a Positive Determinant for Pseudoknot-Stimulated -1 Ribosomal Frameshifting. Proc. Natl. Acad. Sci. USA 102, 12694-12699.

Pennella, M. A., & GIEDROC, D. P. (2005) Structural Determinants of Metal Selectivity in Prokaryotic Metal-Responsive Transcriptional Regulators. Biometals 18, 413-428 (invited review).

Apuy, J. A., Busenlehner, L. S., Russell, D. H., & GIEDROC, D. P. (2004) Ratiometric Pulsed Alkylation-Mass Spectrometry as a Probe of Thiolate Reactivity in Different Metalloderivatives of S. aureus pI258 CadC Biochemistry 43, 3824-3834.

Chen, X., Zhang, B., Harmon, P. M., Schaffner, W., Peterson, D. O., & GIEDROC, D. P. (2004) A Novel Cysteine Cluster in Human MTF-1 is Required for Heavy Metal-induced Transcriptional Activation in vivo. J. Biol. Chem. 279, 4515-4522.

Eicken, C., Pennella, M. A., Chen, X., Koshlap, K., VanZile, M. L., Sacchettini, J. C., & GIEDROC, D. P. (2003) A Metal-Ligand mediated Intersubunit Allosteric Switch in Related SmtB/ArsR Zinc Sensor Proteins. J. Mol. Biol. 333, 683-695.

GIEDROC, D. P., Cornish, P. V., & Hennig, M. A. (2003) Detection of Scalar Couplings Involving 2'-Hydroxyl Protons Across Hydrogen Bonds in a Frameshifting RNA Pseudoknot. J. Am. Chem. Soc 125, 4676-4677.

Pennella, M. A., Shokes, J. E., Cosper, N. J., Scott, R. A., & GIEDROC, D. P. (2003) Structural Elements of Metal Selectivity in Metal Sensor Proteins. Proc. Natl. Acad. Sci. USA 100, 3713-3718.