Professor, Molecular and Cellular Biochemistry Department
Office: Simon Hall 205A
BS, Microbiology and Biology, University of Michigan
PhD, Microbiology, Michigan State University
We are interested in both basic and applied studies of how RNA viruses interact with the host cell. The lab has three interrelated areas of focus, and these have the potential to enrich each other.
Kao C, B. Fan, S. Chinnaswamy, H. Cai, C.T. Ranjith-Kumar, and J. Deval. 2011. Assays for RNA synthesis and replication by the hepatitis C virus. Frontiers in Biol. DOI 10.1007/s11515-012-1188-0
Ni P., Wang Z., Ma X., N. Das, P. J. Sokol, Chiu W., Dragnea B., M. Hagan and C. Cheng Kao. 2012. An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus capsid protein and RNA packaging. J, Mol. Biol. 419:284-300.
Bhardwaj, K. P. Liu, J. L. Leibowitz, and C. C. Kao. 2012. SARS viral Nsp15 interacts with the retinoblastoma tumor suppressor protein. J. Virol. 86: 4294-4304.
Subba-Reddy Ch. V., B. Tragesser, Z. Xu. B. Stein, Ranjith-Kumar CT, and C. C. Kao. 2012. Brome mosaic virus 1a protein modulates 2a polymerase activity in human cells. J. Virol. 86: 4317-4327
Tsevtkova I, C. Chen C., S. Rana, C. Cheng Kao, V. M. Rotello, and B. Dragnea. 2012. Pathway switching in templated virus-like particle assembly. Soft Matter. DOI: 10.1039/c2sm00024e.
Vaughan R., W. Running, R. Qi, and C. C. Kao. 2012. Rapid mapping of protein RNA interaction. Virus Adaptations and Treatments. 2012:4 1–13.
Shu C., G. Yi, T. Watts, C. C. Kao, and P. Li. 2012. Structure of STING bound to c-di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat. Struct. Mol. Biol. Doi:10.1038/nsmb.2331
Vaughan R, B. Fan, J.-S. You, and C. C. Kao. Identification and functional characterization of the nascent RNA channel of the hepatitis C virus RNA-dependent RNA polymerase. RNA 18:1541-1552.
Running, W., N. Peng, C. Kao, and J. Reilly. Mapping the pH-dependent conformational changes in the brome mosaic virus virions. J. Mol. Biol. 423:79-95.
Subba-Reddy Ch. V., Muhammad Amir Yunus, Ian G. Goodfellow, and C. Cheng Kao. Norovirus RNA synthesis is modulated by an interaction between the viral RNA-dependent RNA polymerase and the major capsid protein, VP1. J. Virol. 86:10138-10149.
Qi, R. D. Singh, C. Cheng Kao. Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization. J. Biol. Chem. 287:32617-32629.
Goicochea, N. L., S. A. K. Datta, A. Rein, M. Ayaluru, C. C. Kao, Bogdan Dragnea. 2011. Structural properties of template-directed recombinant HIV-1 GAG particles.
Huang, X., Stein, B., Cheng, H., Malyutin, A., Tsvetkova, I., Baxter, D., Remmes, N., Verchot, J., Kao, C., Bronstein, L., and Dragnea, Bogdan. 2011. Magnetic virus-like nanoparticles in N. benthamiana plants a new paradigm for environmental and agronomic biotechnological research. ACS Nano. In press.
Qi X., T. Droste, and C. C. Kao. 2011. Cell-penetrating peptides derived from viral capsid Proteins. Molec. Plant-Microbe Interact. 24:25-36.
Ranjith-Kumar C. T., Y. Y. Lai, R. T. Sarisky, and C. C. Kao. 2010 Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I. PLoS One 5(9): e12878. doi:10.1371/journal.pone.0012878.
Lu C., C.T. Ranjith-Kumar, L. Hao, C. C. Kao, and P. Li. 2010. Crystal structure of human RIG-I C-terminal domain bound to a blunt-ended double-stranded RNA. NAR 2010, 1-11.
Hwang J., L. Huang, D. G. Cordek, R. Vaughan, S. L. Reynolds, G. Kihara, K. D. Raney, C. Cheng Kao, and C. E. Cameron. 2010. Hepatitis C virus nonstructural protein 5A (NS5A): biochemical characterization of a novel structural class of RNA-binding proteins. J. Virol. 84:12480-12491.
Qi, R. S. Hoose, J. Schreiter, K. V. Sawant, R. Lamb, C.T. Ranjith-Kumar, J. Mills, L. San Mateo, J. L. Jordan, and C. C. Kao. 2010. Secretion of the human Toll-like Receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by UNC93B. J. Biol. Chem. 285:36635-36645.
Qi X., T. Droste, and C. C. Kao. 2010. Cell-penetrating peptides derived from viral capsid Proteins. Molec. Plant-Microbe Interact. 24:25-36.
Ortiz-Alcantara, J. K. Bhardwaj, S. Palaninathan, M. Frieman, R. S. Baric, C. C. Kao. 2010. Small molecule inhibitors of the SARS-CoV nsp15 endoribonuclease. Virus Adaptation and Treatment. Virus Adaptation and Treatment 2010:125-133.
Lu C., H. Xu, C.T. Ranjith-Kumar, M. T. Brooks, T. Y. Hu, A. B. Herr, R. K. Strong, C. Cheng Kao, and P. Li. 2010. The structural basis of 5' triphosphate double-stranded RNA recognition by the RIG-I C-terminal domain. Structure 18, 1-12.
Daniel M.-C., I. Tsvetkova, Z. Quinkert, A. Murali, M. De, V. L. Rotello, C. C. Kao, and B. Dragnea. 2010. Critcal surface charge density is required for nanoparticle-templated assembly by bromovirus protein cages. ACS-Nano 4. 3853-3860.
Hema, M., A. Murali, K. Fujisaki, I. Tsvetkova, P. Ni, R. C. Vaughan, B. Dragnea, and C. Cheng Kao. 2010. A single amino acid substitution in the brome mosaic virus capsid protein resulted in biased RNA packaging. Molec. Plant Microb. Interact. 23:1433-1447.