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Indiana University Bloomington

Faculty from several departments participate in our Graduate Program. They are listed according to the following research area.

students in labs

Susanne ResslSusanne Ressl

 

Assistant Scientist, Molecular and Cellular Biochemistry Department

Office: Simon Hall SI 305A

Phone: 812/856-5801

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Lab Website

Affiliations

Indiana University Department of Neuroscience

Education

B.S. 2003 University of Mainz (Germany)-Biology
M.S. 2006 University of Mainz (Germany) Honors Thesis at the Max-Planck
Institute of Biophysics-Biophysics, Immunology,
Zoology
Ph.D. 2009 Max-Planck Institute of Biophysics (University of Frankfurt)
(Germany)-Biochemistry, Biophysics
2010-2014 Postdoctoral Fellow at Stanford University CA with Axel T. Brunger - Structural Neuroscience 
2010-2011 EMBO Longterm Fellowship
2012-2014 Otto-Hahn Fellowship of the Max-Planck Society Germany

Research

Structural Neuroscience, synaptic adhesion molecules, molecular interface of the synaptic cleft, C1Q-like proteins as synaptic organizers, X-ray crystallography and Cryo-electron microscopy, membrane protein crystallography.

Representative Publications

Gabale U, Qian G, Roach E, Ressl S. Crystallization and preliminary X-ray diffraction analysis of YejM from Salmonella typhimurium: an essential inner membrane protein involved in outer membrane directed cardiolipin transport. Version 2. F1000Res. 2017 Jan 1

Sunden F., AlSadhan I., Lyubimov A.Y., Ressl S., …, Herschlag D. “Mechanistic similarities and distinctions of phosphomonoesterases and phosphodiesterases across the alkaline phosphatase superfamily revealed through comparative enzymology”  J Am Chem Soc Sep 16 2016

Martinelli D.C., Chew K.S., Rohlmann A., Lum M., Ressl S., Hattar S., Brunger A.T., Missler M., Südhof T.C. “Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors” NEURON Sep 7;91(5):1034-51  2016

Sunden F., Peck A., Salzman J., Ressl S., Herschlag D. (2015) "Extensive site-directed mutagenesis reveals interconnected functional units in the Alkaline Phosphatase active site” eLife Sciences 04

Dalebroux Z.D., Edrozo M.B.,  Pfuetzner R.A., Ressl S., Kulasekara B.R., Blanc MP., Miller S.I. (2015) "Delivery of Cardiolipins to the Salmonella Outer Membrane Is Necessary for Survival within Host Tissues and Virulence” Cell Host & Microbe 17, 1–11, April 8, 2015

Zhang Y, Diao J, Colbert KN, Lai Y, Pfuetzner RA, Padolina MS, Vivona S, Ressl S, Cipriano DJ, Choi UB, Shah N, Weis WI, Brunger AT. (2015) "Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin.” J Biol Chem. 2015 Feb 25.

Ressl S, Vu BK, Vivona S, Martinelli DC, Südhof TC, Brunger AT  (2015) “Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily” STRUCTURE 2015 Feb 24

Liebscher I, Ackley B,[......], Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X (2014) “New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors” Annals of the New York Academy of Sciences 11/2014

Korkmaz F, Ressl S, Ziegler C, Mäntele W (2013) “K(+)-induced conformational changes in the trimeric betaine transporter BetP monitored by ATR-FTIR spectroscopy” Biochimica et Biophysica Acta 1828: 1181-1191

Perez C, Koshy C, Ressl S, Nicklisch S, Krämer R, Ziegler C (2011) “Substrate specificity and ion coupling in the Na+/betaine symporter BetP” The EMBO Journal 30:1221-9

Kraemer R, Ressl S, Ott V, Nicklisch S, Steinhoff HJ, Forrest L, Ziegler C (2010)”Betp - X-Ray Structure and Function of An Osmosensor and Transporter” Biophysical Journal 98(3)

Ressl S, Terwisscha van Scheltinga AC, Vonrhein C, Ott V., Ziegler C (2009) “Molecular basis of transport and regulation in the Na+/betaine symporter BetP”

Nature 458: 47-52