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Indiana University Bloomington

Faculty from several departments participate in our Graduate Program. They are listed according to the following research area.

students in labs

Carl BauerJoshua Ziarek

Assistant Professor, Molecular and Cellular Biochemistry Department

Office: 305C

Phone: 855-4573

Send Email

Lab WebsiteTBA

Education

B.S., University of Wisconsin-Milwaukee, 2007
Ph.D., Medical College of Wisconsin, 2011
Postdoctoral Training, Harvard Medical School, 2012-2017

Research

Deciphering the conformational dynamics of GPCR activation using biophysical, biochemical and cell-based approaches.

Representative Publications

Ziarek, J.J., Kleist, A.B, London, N., Raveh, B., Montpas, N., Bonneterre, J., St-Onge, G., DiCosmo-Ponticello, C.J., Koplinski, C.A., Roy, I., Stephens, B., Thelen, S., Veldkamp, C.T., Coffman, F.D., Cohen, M.C., Dwinell, M.B., Thelen, M., Peterson, F.C., Heveker, N. & Volkman, B.F. 2017. Structural basis for chemokine recognition of a G protein-coupled receptor and implications for receptor activation. Science Signaling, 10:eaah5756.

Wommack, A.J., Ziarek, J.J., Tomaras, J., Chileveru, H.R., Zhang, Y., Wagner, G. & Nolan, E.M. 2014. Discovery and characterization of a disulfide-locked C2-symmetric defensin peptide. Journal of the American Chemical Society, 136(39):13494-13497.

Ziarek, J.J.*, Getschman, A.E.*, Butler, S.J., Taleski, D., Stephens, B., Kufareva, I., Handel, T.M., Payne, R.J. & Volkman, B.F. 2013. Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chemical Biology, 8:1955-1963. *Equal contributors.

Ziarek, J.J., Veldkamp, C.T., Zhang, F. Murray, N.J., Kartz, G.A., Liang, X., Su, J., Baker, J.E., Lindhardt, R.J. & Volkman, B.F. 2013. Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus. Journal of Biological Chemistry, 288:737-746.

Mysinger, M.M.*, Weiss, D.R.*, Ziarek, J.J.*, Gravel, S., Doak, A.K., Karpiak, J., Heveker, N., Shoichet, B.K. & Volkman, B.F. 2012. Structure-based ligand discovery for chemokine receptor CXCR4. Proceedings of the National Academy of Sciences of the United States of America, 109: 5517-5522.*Equal contributors.

Drury, L.D.*, Ziarek, J.J.*, Gravel, S., Veldkamp, C.T., Takekoshi, T., Hwang, S.T., Heveker, N., Volkman, B.F. & Dwinell, M.B. 2011. Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proceedings of the National Academy of Sciences of the United States of America, 108: 17655-17660. *Equal contributors.

Veldkamp, C.T., Ziarek, J.J., Peterson, F.C., Chen, Y. & Volkman, B.F. 2010. Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure based drug design. Journal of the American Chemical Society, 132: 7242-7243.