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Indiana University Bloomington

Anirban MitraZachary Aron

Assistant Professor, Department of Chemistry

Office: Chemistry A361

Phone: 812/ 856-4862

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Lab Website

Education

University of Illinois at Urbana-Champaign, 1999.
Ph.D, University of California at Irvine, 2004.
Postdoctoral Fellow, Harvard Medical School, 2007.

Research

Research in the Aron lab is focused on the development of molecular assembly lines as versatile tools for chemical synthesis. Using biosynthetic pathways as both starting point and inspiration, we are working to build reconfigurable multifunctional catalysts that allow specific access to a variety of structures. These efforts are multidisciplinary in nature, encompassing enzymology, protein engineering, directed evolution, peptide folding, nanotechnology, organic methodology and total synthesis.

Representative Publications

Hutt, J. T.; Jo, J.; Chen, C.-H.; Lee, D.; Aron, Z. D. Imidazo[1,5-a]pyridinium Salts: Water Soluble Fluorescent pH Sensors Displaying Both PET and ICT Responses. in preparation.

Fang, P. Aron, Z. D. Catalytic, Asymmetric alpha-Allylation of Unprotected Amino Acid Esters. in submission.

Hutt, J. T.; Aron, Z. D. Efficient, Single-Step Access to Imidazo[1,5-a]pyridine N-Heterocyclic Carbene Precursors. Org. Lett. 2011, 13, 5256-5259.

Chaulagain, M. R.; Aron, Z. D. A Diastereoselective Three-Component Coupling Approach to Highly Substituted Pyrrolidines. J. Org. Chem. 2010, 75, 8271-8274.

Felten, A. E.; Zhu, G.; Aron, Z. D. Simplifying Pyridoxal: Practical Methods for Amino Acid Dynamic Kinetic Resolution. Org. Lett. 2010, 12, 1916-1919.

Strieter, E. R.; Koglin, A.; Aron, Z. D.; Walsh, C. T. Cascade Reactions during Coronafacic Acid Biosynthesis: Elongation, Cyclization, and Functionalization during Cfa7-Catalyzed Condensation. J. Am. Chem. Soc. 2009, 131, 2113-2115.

Hansen, D. B.; Bumpis, S.; Aron, Z. D.; Kelleher, N. L.; Walsh, C. T. The Loading Module of Mycosubtilin: an Adenylation Domain With Fatty Acid Selectivity. J. Am. Chem. Soc. 2007, 129, 6366-6367.

Aron, Z. D.; Fortin, P. D.; Calderone, C. T.; Walsh, C. T. FenF: Servicing the Mycosubtilin Synthetase Assembly Line in Trans. ChemBioChem, 2007, 8, 613-616.

Dorrestein, P. C.; Bumpus, S. B.; Calderone, C. T.; Garneau-Tsodikova, S.; Aron, Z. D.; Straight, P. D.; Kolter, R.; Walsh C. T.; Kelleher, N. L. Facile Detection of Acyl- and Peptidyl-intermediates on Thiotemplate Carrier Domains via Phosphopantetheinyl Elimination Reactions During Tandem Mass Spectrometry. Biochemistry. 2006, 45, 12756-12766.

Aron, Z. D.; Dorrestein, P. C.; Blackhall, J. R.; Kelleher, N. L.; Walsh, C. T. Characterization of a New Tailoring Domain in Polyketide Biogenesis: The Amine Transferase Domain of MycA in the Mycosubtilin Gene Cluster. J. Am. Chem. Soc. 2005, 127, 14986-14987.