Zachary D. Aron
Assistant Professor, Chemistry
Education
B.S. 1999 Chemistry University of Illinois at Urbana-Champaign.
Ph.D. 2004 University of California at Irvine
Postdoctoral Fellow Harvard Medical School
Research
Studies of how biosynthetic tools and strategies can be used to generate biologically active small molecules; relevant areas include polyketide biosynthesis, enzyme engineering, enzyme mimetics, natural product synthesis and therapeutics discovery.
Representative Publications
Chaulagain, M. R.; Aron, Z. D. A Diastereoselective Three-Component Coupling Approach to Highly Substituted Pyrrolidines. J. Org. Chem. 2010, 75, 8271-8274.
Felten, A. E.; Zhu, G.; Aron, Z. D. Simplifying Pyridoxal: Practical Methods for Amino Acid Dynamic Kinetic Resolution. Org. Lett. 2010, 12, 1916-1919.
Aron, Z. D.; Fortin, P. D.; Calderone, C. T.; Walsh, C. T. FenF: Servicing the Mycosubtilin Synthetase Assembly Line in Trans. ChemBioChem, 2007, 8, 613-616.
Aron, Z. D.; Dorrestein, P. C.; Blackhall, J. R.; Kelleher, N. L.; Walsh, C. T. Characterization of a New Tailoring Domain in Polyketide Biogenesis: The Amine Transferase Domain of MycA in the Mycosubtilin Gene Cluster. J. Am. Chem. Soc. 2005, 127, 14986-14987.
Aron, Z. D.; Overman, L. E. Stereocontrolled synthesis of Angularly Substituted 1-Aza-bicyclic Rings by Cationic 2-Aza-Cope Rearrangements. Org. Lett. 2005, 7, 913-916.
Aron, Z. D.; Overman, L. E. Total Synthesis and Properties of the Crambescidin Core Zwitterionic Acid and Crambescidin 359. J. Am. Chem. Soc. 2005, 127, 3380-3390.
Aron, Z. D.; Overman, L. E.; Pietraszekiewicz, H.; Valeriote, F. Synthesis and Biological Activity of Crambescidin Analogs. Bioorg. Med. Chem. Lett. 2004, 14, 3445-3449.
