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Indiana University Bloomington

Carl BauerCarl Bauer

Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 305A

Phone: 812/855-6595

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Lab Website

Education

Ph.D., University of Illinois, 1986
Postdoctoral Fellow, E. I. du Pont de Nemours & Co.

Research

Oxygen and light regulation of gene expression; biosynthesis of heme and chlorophyll; prokaryotic development.

Representative Publications

Cheng, Z., K. Li, L. A. Hammond, J. A. Karty & C. E. Bauer (2014) B12 controls photosystem gene expression by light regulated binding to the antirepressor AerR. Mol. Microbiol. In Press.  NIHMSID 550433  (This work was highlighted in a companion commentary in the same issue by G. Klug.)

Zappa, S. & C. E. Bauer.  (2013) The LysR-Type Transcription Factor HbrL Is A Global Regulator Of Iron Homeostasis And Porphyrin Synthesis In Rhodobacter capsulatus. Mol Microbiology. 90:1277-1292  PMC3875232

Yin, L., V. Dragnea, G. Fieldman, L. A. Hammand, J. A. Karty, C. Dann & C. E. Bauer. (2013) Redox and light control of the heme sensing activity of AppA.  mBio 4: e00563-13

Yin, L, & C. E. Bauer (2013) Controlling The Delicate Balance of Tetrapyrrole BiosynthesisPhil. Trans. Royal. Soc. B.  368 no. 1622 20120253. NIHMSID # 442635

Zappa, S. & C. E. Bauer.  (2013)  Iron homeostasis in the Rhodobacter genus. In Genome Evolution of Photosynthetic Bacteria. Edt. T. J. Beatty. Advances in Botanical Research, 66:289-326. NIHMSID # 442638

Wu, J, V Dragnea & CE Bauer  (2012) Redox Responding Sensor Kinases.  In Two Component Systems in Bacteria. Ed. R Gross and D Beier.  pp 41-56. Horizon Scientific Press.

Wu J, Cheng Z, Reddie K, Carroll K, Hammad LA, Karty JA, & Bauer CE. (2013) RegB kinase activity is repressed by oxidative formation of cysteine sulfenic acidJ. Biol. Chem. 288:4755-4762. PMID: 23306201

Yin, L, V Dragnea, & Bauer CE (2012) PpsR, a regulator of heme and bacteriochlorophyll biosynthesis, is a heme-sensing protein. J. Biol Chem.  287:13850-13858. PMID: 22378778

Cheng, Z, J Wu, A Setterdahl, K Reddie, K Carroll, L A. Hammad, J A Karty & CE Bauer (2012) Activity of the tetrapyrrole regulator CrtJ is controlled by oxidation of a redox active cysteine located in the DNA binding domain.  Mol. Micro. 85:734-746  PMID: PMC3418406

Yuan H, V Dragnea, Q Wu, KH Garner & Bauer CE (2011) Mutational and structural studies of the PixD BLUF output signal that affects light-regulated interactions with PixE. Biochemistry 50:6365-6375 PMID: 21688827

Wu J, Bauer CE (2010) RegB kinase activity is controlled in part by monitoring the ratio of oxidized to reduced ubiquinones in the ubiquinone pool. MBio. 1. pii: e00272-10.

Dragnea V, Arunkumar AI, Lee CW, Giedroc DP, Bauer CE. (2010) A Q63E Rhodobacter sphaeroides AppA BLUF domain mutant is locked in a pseudo-light-excited signaling state. Biochemistry. 49:10682-90. PMID: 2108279

Dragnea V, Arunkumar AI, Yuan H, Giedroc DP, Bauer CE.(2009) Spectroscopic studies of the AppA BLUF domain from Rhodobacter sphaeroides: addressing movement of tryptophan 104 in the signaling state.Biochemistry. 48:9969-79. PMID: 19746968

Yuan, H. and C. E. Bauer. 2008. PixD promotes dark oligomerization of the BLUF photoreceptor PixD.  Proc. Natl. Acad. Sci. USA  105, 11715-11719.

Masuda, S., J. Berleman, B. M. Hasselbring and C. E. Bauer. 2008. Regulation of aerobic photosystem synthesis in the purple bacterium Rhodospirillum centenum by CrtJ and AerR. Photochem.  Photobiol. Sci. 7, 1267–1272

Yuan, H., & C. E. Bauer. 2008. PixE promotes Dark Oligomerization of the BLUF Photoreceptor PixD. Proc. Natl Acad. Sci. USA. In Press.

Prokaryotic Differentiation

He, K., J. M. Marden, E. M. Quardokus & C. E. Bauer (2013) Phosphate Flow between Hybrid Histidine Kinases CheA3 and CheS3 Controls Rhodospirillum centenum Cyst Formation. PLOS Genetics, DOI: 10.1371/journal.pgen.1004002

Marden, JN, JE Berleman, CE Bauer. 2011. Cyclic GMP regulates encystment in Rhodospirillum centenum.  Mol. Micro. 79:600-615 (Commentary of this study in Mol. Micro 79:562-565). PMID: 21214648

Marden, JN, JE Berleman, CE Bauer. 2011. Cyclic GMP regulates encystment in Rhodospirillum centenum.  Mol. Micro. 79:600-615 (Commentary of this study in Mol. Micro 79:562-565). PMID: 21214648

Lu YK, Marden J, Han M, Swingley WD, Mastrian SD, Chowdhury SR, Hao J, Helmy T, Kim S, Kurdoglu AA, Matthies HJ, Rollo D, Stothard P, Blankenship RE, Bauer CE, Touchman JW (2010) Metabolic flexibility revealed in the genome of the cyst-forming alpha-1 proteobacterium Rhodospirillum centenum.  BMC Genomics. 11:325.

Lu YK, Marden J, Han M, Swingley WD, Mastrian SD, Chowdhury SR, Hao J, Helmy T, Kim S, Kurdoglu AA, Matthies HJ, Rollo D, Stothard P, Blankenship RE, Bauer CE, Touchman JW (2010) Metabolic flexibility revealed in the genome of the cyst-forming alpha-1 proteobacterium Rhodospirillum centenum.  BMC Genomics. 11:325.

Berleman, J., & C. E. Bauer 2005. A chemotaxis like signal transduction cascade controls a cyst developmental pathway in Rhodospirillum centenum . Mol . Microbiol. 55, 1390-1402.

Berelman, J. & C. E. Bauer. 2004.Characterization of the cyst cell formation in the purple photosynthetic bacterium Rhodospirillum centenum . Microbiology150, 383-390 (Featured on cover)

Berleman, J., B.  Hasselbring, & C. E. Bauer. 2004. Hypercyst Mutants in Rhodospirillum centenum Identify Regulatory Loci Involved in Cyst Cell Differentiation. J. Bacteriol. 186, 5834-5841 (Featured on cover).