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Indiana University Bloomington

Carl BauerCarl Bauer

Chair, Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 305A

Phone: 812/855-6595

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Ph.D., University of Illinois, 1986
Postdoctoral Fellow, E. I. du Pont de Nemours & Co.


Oxygen and light regulation of gene expression; biosynthesis of heme and chlorophyll; prokaryotic development.

Representative Publications

Kumka J. E. & C. E. Bauer (2015) Analysis of the FnrL regulon in Rhodobacter capsulatus reveals limited regulon overlap with orthologues from Rhodobacter sphaeroides and Escherichia coli. BMC Genomics 16:895  doi:10.1186/s12864-015-2162-4

Vermeulen, A., & C. E. Bauer(2015) Members of the PpaA/AerR antirepressor family bind cobalamin.  J. Bacteriol. 197:2694-2703. 

Zappa, S & C. E. Bauer (2015)  Regulation of cytochrome biosynthesis.  In Advances in Photosynthesis and Respiration; Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling.  William Cramer and Toivo Kallas (editors). Springer, Dordrecht.  In Press.

Cheng, Z., K. Li, L. A. Hammond, J. A. Karty & C. E. Bauer (2014) B12 controls photosystem gene expression by light regulated binding to the antirepressor AerR. Mol. Microbiol.  91:649-664  NIHMSID 550433  (This work was highlighted in a companion commentary in the same issue by G. Klug.)

Zappa, S. & C. E. Bauer.  (2013) The LysR-Type Transcription Factor HbrL Is A Global Regulator Of Iron Homeostasis And Porphyrin Synthesis In Rhodobacter capsulatus. Mol Microbiology. 90:1277-1292 PMC3875232

Yin, L., V. Dragnea, G. Fieldman, L. A. Hammand, J. A. Karty, C. Dann & C. E. Bauer. (2013) Redox and light control of the heme sensing activity of AppA.  mBio 4: e00563-13

Yin, L, & C. E. Bauer (2013) Controlling The Delicate Balance of Tetrapyrrole BiosynthesisPhil. Trans. Royal. Soc. B. 368 no. 1622 20120253. NIHMSID # 442635

Zappa, S. & C. E. Bauer.  (2013)  Iron homeostasis in the Rhodobacter genus. In Genome Evolution of Photosynthetic Bacteria. Edt. T. J. Beatty. Advances in Botanical Research, 66:289-326. NIHMSID # 442638

Wu J, Cheng Z, Reddie K, Carroll K, Hammad LA, Karty JA, & Bauer CE. (2013) RegB kinase activity is repressed by oxidative formation of cysteine sulfenic acidJ. Biol. Chem. 288:4755-4762. PMID: 23306201

Yin, L, V Dragnea, & Bauer CE (2012) PpsR, a regulator of heme and bacteriochlorophyll biosynthesis, is a heme-sensing protein. J. Biol Chem.  287:13850-13858. PMID: 22378778

Cheng, Z, J Wu, A Setterdahl, K Reddie, K Carroll, L A. Hammad, J A Karty & CE Bauer (2012) Activity of the tetrapyrrole regulator CrtJ is controlled by oxidation of a redox active cysteine located in the DNA binding domain.  Mol. Micro. 85:734-746  PMID: PMC3418406

Prokaryotic Differentiation

Dong, Q., Roychowdhury, S., & C. E. Bauer (2015) Mapping The CgrA Regulon Of Rhodospirillum centenum Reveals a Hierarchal Network Controlling Cyst Development.  BMC Genomics. In Press

Roychowdhury, R. S., Q. Dong & C. E. Bauer.  (2015) DNA binding properties of a cGMP binding CRP homolog that controls development of metabolically dormant cysts of Rhodospirillum centenum.  Microbiology.  161: 2256-2264.

Dong, Q., & C. E. Bauer (2015) Transcriptome analysis of cyst formation in Rhodospirillum centenum reveals large global changes in expression during cyst development.  BMC Genomics. 16:68 DOI: 10.1186/s12864-015-1250-9

He, K., V. Dragnea, & C. E. Bauer (2015) ­­­Adenylate charge regulates sensor kinase ches3 to control cyst formation in Rhodospirillum centenum  mBio, 6:e00546-15

He, K. & C. E. Bauer (2014) Chemosensory signaling that controls bacterial survival.  Trends in Microbiology. 22:389-393

He, K., J. M. Marden, E. M. Quardokus & C. E. Bauer (2013) Phosphate Flow between Hybrid Histidine Kinases CheA3 and CheS3 Controls Rhodospirillum centenum Cyst Formation. PLOS Genetics, DOI: 10.1371/journal.pgen.1004002

Marden, JN, JE Berleman, CE Bauer (2011) Cyclic GMP regulates encystment in Rhodospirillum centenum.  Mol. Micro. 79:600-615 (Commentary of this study in Mol. Micro 79:562-565). PMID: 21214648