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Indiana University Bloomington

Carl BauerCarl Bauer

Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 305A

Phone: 812/855-6595

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Lab Website

Education

Ph.D., University of Illinois, 1986
Postdoctoral Fellow, E. I. du Pont de Nemours & Co.

Research

Oxygen and light regulation of gene expression; biosynthesis of heme and chlorophyll; prokaryotic development.

Representative Publications

Shimizu T., Cheng Z., Matsuura K., Masuda S. & C. E. Bauer (2015) The purple bacterium Rubrivivax gelatinosus utilizes altered cis element spacing to promote redox sensing by the photosynthesis gene-specific transcription factor PpsR.  Submitted

Zappa, S & C. E. Bauer (2015)  Regulation of cytochrome biosynthesis.  In Advances in Photosynthesis and Respiration; Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling.  William Cramer and Toivo Kallas (editors). Springer, Dordrecht.  In Press.

Cheng, Z., K. Li, L. A. Hammond, J. A. Karty & C. E. Bauer (2014) B12 controls photosystem gene expression by light regulated binding to the antirepressor AerR. Mol. Microbiol.  91:649-664  NIHMSID 550433  (This work was highlighted in a companion commentary in the same issue by G. Klug.)

Zappa, S. & C. E. Bauer.  (2013) The LysR-Type Transcription Factor HbrL Is A Global Regulator Of Iron Homeostasis And Porphyrin Synthesis In Rhodobacter capsulatus. Mol Microbiology. 90:1277-1292 PMC3875232

Yin, L., V. Dragnea, G. Fieldman, L. A. Hammand, J. A. Karty, C. Dann & C. E. Bauer. (2013) Redox and light control of the heme sensing activity of AppA.  mBio 4: e00563-13

Yin, L, & C. E. Bauer (2013) Controlling The Delicate Balance of Tetrapyrrole BiosynthesisPhil. Trans. Royal. Soc. B. 368 no. 1622 20120253. NIHMSID # 442635

Zappa, S. & C. E. Bauer.  (2013)  Iron homeostasis in the Rhodobacter genus. In Genome Evolution of Photosynthetic Bacteria. Edt. T. J. Beatty. Advances in Botanical Research, 66:289-326. NIHMSID # 442638

Wu, J, V Dragnea & CE Bauer  (2012) Redox Responding Sensor Kinases.  In Two Component Systems in Bacteria. Ed. R Gross and D Beier.  pp 41-56. Horizon Scientific Press.

Wu J, Cheng Z, Reddie K, Carroll K, Hammad LA, Karty JA, & Bauer CE. (2013) RegB kinase activity is repressed by oxidative formation of cysteine sulfenic acidJ. Biol. Chem. 288:4755-4762. PMID: 23306201

Yin, L, V Dragnea, & Bauer CE (2012) PpsR, a regulator of heme and bacteriochlorophyll biosynthesis, is a heme-sensing protein. J. Biol Chem.  287:13850-13858. PMID: 22378778

Cheng, Z, J Wu, A Setterdahl, K Reddie, K Carroll, L A. Hammad, J A Karty & CE Bauer (2012) Activity of the tetrapyrrole regulator CrtJ is controlled by oxidation of a redox active cysteine located in the DNA binding domain.  Mol. Micro. 85:734-746  PMID: PMC3418406

Yuan H, V Dragnea, Q Wu, KH Garner & Bauer CE (2011) Mutational and structural studies of the PixD BLUF output signal that affects light-regulated interactions with PixE. Biochemistry 50:6365-6375 PMID: 21688827

Prokaryotic Differentiation

Dong, Q., Roychowdhury, S., & C. E. Bauer (2015) Mapping the cgra regulon of Rhodospirillum centenum reveals a hierarchal network controlling cyst development.  Submitted

Roychowdhury, R. S., Q. Dong & C. E. Bauer.  (2015) DNA binding properties of a cGMP binding CRP homolog that controls development of metabolically dormant cysts of Rhodospirillum centenum.  Submitted

Dong, Q., & C. E. Bauer (2015) Transcriptome analysis of cyst formation in Rhodospirillum centenum reveals large global changes in expression during cyst development.  BMC Genomics.  In Press

He, K. & C. E. Bauer (2014) Chemosensory signaling that controls bacterial survivalTrends in Microbiology. 22:389-393

He, K., J. M. Marden, E. M. Quardokus & C. E. Bauer (2013) Phosphate Flow between Hybrid Histidine Kinases CheA3 and CheS3 Controls Rhodospirillum centenum Cyst Formation. PLOS Genetics, DOI: 10.1371/journal.pgen.1004002

Marden, JN, JE Berleman, CE Bauer. 2011. Cyclic GMP regulates encystment in Rhodospirillum centenum.  Mol. Micro. 79:600-615 (Commentary of this study in Mol. Micro 79:562-565). PMID: 21214648