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Indiana University Bloomington

Stephen BellStephen Bell

Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 405A

Phone: 812/856-2331

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Lab Website

Education

PhD University of Glasgow, Scotland, 1992
Postdoctoral Fellow, University of Glasgow (1992-1995)
Postdoctoral Fellow, Gurdon Inst. Cambridge, UK (1996-2001)

Research

We study the molecular and cellular biology of the Archaea, with particular interest in transcription, DNA replication and cell division.

Representative Publications

R.Y. Samson, Y Xu, C. Gadelha, T. Stone, J. Faqiri, D. Li, N. Qin, F. Pu, Y.X. Liang, Q She and S.D. Bell (2013) “Specificity and function of archaeal DNA replication initiator proteins” Cell Reports 3, 485-496

J. Snyder, R.Y. Samson, S. Brumfield, S.D. Bell and M. Young (2013). “Functional interplay between a virus and the ESCRT machinery in Archaea” PNAS, 110, 10783-10787

M. Dobro, R.Y. Samson, S.D. Bell, G. J. Jensen. (2013) “Molecular basis of ESCRT-driven cell division” Mol. Biol. Cell, 24, 2319-2327

R.Y Samson and S.D. Bell (2013) “MCM Loading – an open-and-shut case?” Molecular Cell, 50, 457-458

C. Tiengwe, L. Marcello, H. Farr, N. Dickens, S. Kelly, M. Swiderski, D. Vaughn, K. Gull  J.D. Barry, S.D. Bell and R. McCulloch (2012) “Interplay between DNA replication and transcription in the Trypanosoma brucei genome” Cell Reports 2, 185-197

T.R. Beattie and S.D. Bell (2012) “Coordination of multiple enzyme activities by a single PCNA ring in archaeal Okazaki fragment maturation” EMBO J. 31, 1556-1567

R.Y. Samson, T. Obita P. L-G Chong, R.L. Williams and S.D. Bell (2011) “Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division” Molecular Cell, 41, 186-196

E.R. Barry, J. Lovett, A. Costa, S.M. Lea and S.D. Bell (2009) “Inter-subunit allosteric communication mediated by a conserved loop in the MCM helicase” Proc. Natl. Acad. Sci. USA, 106, 1051-1066

R.Y. Samson, T. Obita, S.M. Freund, R.L. Williams and S.D. Bell (2008) “A role for the ESCRT system in cell division in Archaea” Science 322, 1710-1713

I.G. Duggin and S.D. Bell (2008) “Chromosome Replication Dynamics in the Archaeon Sulfolobus acidocaldarius” Proc Natl Acad Sci U S A 105, 16737-16742

M.J. Moreau, A.T. McGeoch, A.R. Lowe, L.S. Itzhaki and S.D..Bell (2007) “ATPase site architecture and helicase mechanism of an archaeal MCM” Molecular Cell 28, 304-314

N.P. Robinson, K.A. Blood, S. McCallum, P.A.W. Edwards and S.D. Bell (2007) “Sister chromatid junctions in the archaeon Sulfolobus solfataricus” EMBO J. 26, 816-824

A.T. McGeoch, M.A. Trakselis, R.A. Laskey and S.D. Bell (2005).  “Organisation of the archaeal MCM complex on DNA and implications for helicase mechanism” Nature Struct. Mol. Biol. 12, 756-762

N.P. Robinson, I. Dionne, M. Lundgren, V.L. Marsh, R. Bernander and S.D. Bell (2004) “Identification of two origins of replication in the single chromosome of the archaeon Sulfolobus solfataricus” Cell 116, 25-38