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Indiana University Bloomington


Carl BauerMatthew L. Bochman

Assistant Professor, Molecular and Cellular Biochemistry Department

Office: Simon Hall 405B

Phone: 812/856-2095

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Lab Website


B.S., Juniata College, 2003
Ph.D., University of Pittsburgh, 2008
Postdoctoral Fellow, Princeton University, 2009-2013


The maintenance of genomic integrity with a focus on DNA helicases and other factors involved in DNA replication, recombination, and repair; the evolution of DNA helicases. The science of fermentation.

Representative Publications

Bochman, ML and Schwacha, A. (2015) Nature. Strand separation unraveled. Aug 13; 524(7564): 166-7.

Bochman, ML. (2014) Molecular and Cellular Oncology. Roles of DNA helicases in the maintenance of genome integrity. 1:3, e963429.

Rogers, C, van Kessel, K, and Bochman, ML. (2014) OA Biology. Helicases involved in DNA inter-strand crosslink repair. Feb 22; 2 (1): 4.

Zhou, R, Zhang, J, Bochman, ML, Zakian, VA, and Ha, T. (2014) eLife. Periodic patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA. Apr 29; 3: e02190.

Bochman ML, Paeschke K, Chan A, Zakian VA. Hrq1, a Homolog of the Human RecQ4 Helicase, Acts Catalytically and Structurally to Promote Genome Integrity. Cell Rep. 2014 Jan 30; 6(2): 346-356. doi: 10.1016/j.celrep.2013.12.037. PMID: 24440721.

Simon, N, Bochman, ML, Seguin, S, Brodsky, JL, Seibel, WL, and Schwacha, A. (2013) Bioscience Reports. Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase. Sep. 3; 33 (5): e00072.

Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature. 2013 May 23;497(7450):458-62. doi: 10.1038/nature12149. Epub 2013 May 8. PMID: 23657261.

Bochman ML, Paeschke K, Zakian VA. DNA secondary structures: stability and function of G-quadruplex structures. Nat Rev Genet. 2012 Nov;13(11):770-80. doi: 10.1038/nrg3296. Epub 2012 Oct 3. Review. PMID: 23032257.

Bochman ML, Judge CP, Zakian VA. The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? Mol Biol Cell. 2011 Jun 15;22(12):1955-9. doi: 10.1091/mbc.E11-01-0045. PMID: 21670310.

Bochman ML, Schwacha A. The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'. Nucleic Acids Res. 2010 Oct;38(18):6078-88. doi: 10.1093/nar/gkq422. Epub 2010 May 19. PMID: 20484375.

Bochman ML, Sabouri N, Zakian VA. Unwinding the functions of the Pif1 family helicases.
DNA Repair (Amst). 2010 Mar 2;9(3):237-49. doi: 10.1016/j.dnarep.2010.01.008. Epub 2010 Jan 25. Review. PMID: 20097624.

Bochman ML, Schwacha A. The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev. 2009 Dec;73(4):652-83. doi: 10.1128/MMBR.00019-09. Review. PMID: 19946136.

Bochman ML, Bell SP, Schwacha A. Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol. 2008 Oct;28(19):5865-73. doi: 10.1128/MCB.00161-08. Epub 2008 Jul 28. PMID: 18662997.

Bochman ML, Schwacha A. The Mcm2-7 complex has in vitro helicase activity. Mol Cell. 2008 Jul 25;31(2):287-93. doi: 10.1016/j.molcel.2008.05.020. PMID: 18657510.

Bochman ML, Schwacha A. Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step. J Biol Chem. 2007 Nov 16;282(46):33795-804. Epub 2007 Sep 25. PMID: 17895243.