Joseph A. Bonanno
Professor, Optometry
Education
M.S. in Biology (1977) University of California, Berkeley
O.D. in Optometry (1981) University of California, Berkeley
Ph.D. in Physiological Optics (1987) University of California, Berkeley
Research
Regulation of cell membrane ion transport phenomena in the eye; Role of carbonic anhydrases in bicarbonate transport and cellular buffering capacity; Borate transport and role of borate in oxidative stress; Hypoxia preconditioning cellular protection.
Representative Publications
Jinhua Li, Xing Cai Sun, and Joseph A Bonanno. Role of NBC-1 in Apical and Basolateral HCO3- Permeabilities and Transendothelial HCO3- Fluxes in Bovine Corneal Endothelium. Am J Physiol Cell Physiol. 2005 Mar; 288(3):C739-46.
Hua Yang, Stefan Mergler, Xingcai Sun, Zheng Wang, Luo Lu, Joseph A. Bonanno, Uwe Pleyer, and Peter S. Reinach. TRPC4 Knockdown Suppresses Epidermal Growth Factor-induced Store-operated Channel Activation and Growth in Human Corneal Epithelial Cells J. Biol. Chem. 2005; 280 32230-32237.
Yan Zhang, Jinhua Li, Qiang Xie and Joseph A. Bonanno. Molecular expression and functional involvement of the bovine calcium-activated chloride channel 1 (bCLCA1) in apical HCO3− permeability of bovine corneal endothelium Exp Eye Res. 2006 Nov; 83(5):1215-24.
Xing Cai Sun, Jinhua Li, Miao Cui, and Joseph A. Bonanno. Role of Carbonic Anhydrase IV in Corneal Endothelial HCO3- Transport. Invest. Ophthalmol. Vis Sci. 2008, 49: 1048-1055.
Jinhua Li, KT Allen, X Sun, and JA Bonanno. Dependence of cAMP meditated increases in Cl(-) and HCO(3)(-) permeability on CFTR in bovine corneal endothelial cells. Exp Eye Res. 2008 Apr; 86(4): 684-90.
Xing D, Bonanno JA. Elevated cAMP inhibits TGF{beta}1 induced corneal keratocyte-myofibroblast transformation through Smad independent pathways. Invest Ophthalmol Vis Sci. 2009; 50:626–633.
Hypoxia preconditioning protection of corneal stromal cells requires HIF1alpha but not VEGF. Xing D, Bonanno JA. Mol Vis. 2009 May 18; 15:1020-7.
