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Indiana University Bloomington

Joseph BonannoJoseph A. Bonanno

Professor, Optometry

Office: Optometry Room 307

Phone: 812/856-5977

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Lab Website

Education

M.S. in Biology (1977) University of California, Berkeley
O.D. in Optometry (1981) University of California, Berkeley
Ph.D. in Physiological Optics (1987) University of California, Berkeley

Research

Regulation of cell membrane ion transport phenomena in the eye; Role of carbonic anhydrases in bicarbonate transport and cellular buffering capacity; Borate transport and role of borate in oxidative stress; Hypoxia preconditioning cellular protection.

Representative Publications

Joseph A. Bonanno.  “Molecular Mechanisms Underlying the Corneal Endothelial Pump”. Experimental Eye Research, 2012 95:2-7.

Oxygen-Deficient Metabolism and Corneal Edema. Leung BK, Bonanno JA, and Radke C. Progress in Retinal and Eye Research, 2011 Nov;30(6):471-92

 Tracy T. Nguyen, Joseph A. Bonanno. Bicarbonate and Carbonic Anhydrase Activity Facilitate Lactate-H+ Transport Across Bovine Corneal Endothelium. Invest Ophthalmol Vis Sci. 2011 Oct 17;52(11):8086-93

Liu C, Ogando D, Bonanno JA. SOD2 contributes to anti-oxidative capacity in rabbit corneal endothelial cells. Mol Vis. 2011;17:2473-81.

Tracy T. Nguyen, Joseph A. Bonanno. Lactate-H+ transport is a significant component of the in vivo corneal endothelial pump. Invest Ophthalmol Vis Sci. 2012; 53(4): 2020-9.

Liu J, Seet LF, Koh LW, Venkatraman A, Venkataraman D, Mohan RR, Praetorius J, Bonanno JA, Aung T, Vithana EN. Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line. Invest Ophthalmol Vis Sci. 2012; 53(7):3270-9.

Thore Schmedt, Yuming Chen, Tracy T. Nguyen, Shimin Li, Joseph A. Bonanno, Ula V. Jurkunas.  Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers. PLoS One 2012; 7(12):e51427.

Supriya S. Jalimarada, Diego G. Ogando, Eranga N. Vithana, Joseph A.Bonanno. Ion Transport Function of SLC4A11 in Corneal Endothelium .  InvestOphthalmol Vis Sci.  2013 Jun 21; 54(6):4330-40.

Diego Ogando, S. Jalamarada, W. Zhang, Bonanno, JA. SLC4A11 is an EIPA-sensitive Na+ Permeable pHI Regulator. Am J Physiol Cell Physiol. 2013 Jul 17. [Epub ahead of print]