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Indiana University Bloomington

Yves BrunYves Brun

Clyde Culbertson Professor, Biology

Office: Jordan Hall 425

Phone: 812/855-8860

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Education

Ph.D., Université Laval, Québec, Canada, 1990

Research

Cell cycle control, cell division, and cell differentiation in bacteria; bacterial adhesion and biofilm formation.

Representative Publications

Curtis, P.D. and Y.V. Brun. 2010. Getting in the loop: regulation of development in Caulobacter crescentus. Microbiology and Molecular Biology Reviews, 74: 13-41.

Hughes, V., E., Huitema, S., Pritchard, K.C., Keiler, Y.V., Brun, and P. Viollier. 2010. Protein localization and dynamics within a bacterial organelle. PNAS, 107:5599-604

Hardy, G., R. Allen, E. Toh, M. Long, P.J.B. Brown, J. Cole-Tobian, and Y. V. Brun. 2010. A localized multimeric anchor attaches the Caulobacter holdfast to the cell pole. Molecular Microbiology, 76: 409-427.

Berne, C., D. Kysela, and Y.V. Brun. 2010. A bacterial extracellular DNA inhibits settling of motile progeny cells within a biofilm. Molecular Microbiology, 77: 815-829.

Li, G., Brown, P.B., J.X. Tang, Zhu, J., Quardokus, E.M., Fuqua, C., and Y.V. Brun. 2012. Surface contact stimulates the just-in-time deployment of bacterial adhesins. Molecular Microbiology, 83:41-51.

Brown, P.J.B., M.A. de Pedro, D.T. Kysela, C. Van der Henst, J. Kim, X. De Bolle, C. Fuqua, and Y.V. Brun. 2012. Polar growth in the Alphaproteobacterial Order Rhizobiales. PNAS, 109: 1697-1701.

Curtis, P.D., Quardokus, E.M., Lawler, M.L., Guo, X., Klein, D., Chen, J.C., Arnold, R.J., and Y.V. Brun. 2012. The scaffolding and signaling functions of a localization factor impact polar development. Molecular Microbiology, 84: 712-35.

Madren, S.M., M.D. Hoffman, P.J.B. Brown, D.T. Kysela, Y.V. Brun and S.C. Jacobson. 2012. Microfluidic device for automated synchronization of bacterial cells. Analytical Chemistry, in press.

Schlimpert, S., E. Klein, A. Briegel, H.V. Hughes, J. Kahnt, K. Bolte, U.G. Maier, Y.V. Brun, G.J. Jensen, Z. Gitai, and M. Thanbichler. 2012. Compartmentalization of a bacterial cell by protein diffusion barriers. Cell, in press.

Kuru, E., H.V. Hughes, P.J.B. Brown, E. Hall, S. Tekkam, F. Cava, M.A. de Pedro, Y.V. Brun, and M.S. VanNieuwenhze. In situ Probing of Newly Synthesized Peptidoglycan in Live Bacteria with Fluorescent D-Amino Acids. 2012. Angewandte Chemie, in press.

*Wan, Z., P.B. Brown, E. Elliott, and Y.V. Brun. 2013. The adhesive and cohesive properties of a bacterial polysaccharide adhesin are modulated by a polysaccharide deacetylase. Molecular Microbiology, 88:486-500.

*Javens, J.J., Z. Wan, G.G. Hardy, and Y.V. Brun. 2013. Bypassing the need for subcellular localization of a polysaccharide export-anchor complex by overexpressing its protein subunits. Molecular Microbiology, 89: 350-71

C. Berne, X. Ma, N. Licata, B. Neves, S. Setayeshgar, Y.V. Brun, and B. Dragnea. 2013. Physiochemical Properties of Caulobacter crescentus Holdfast: a Localized Bacterial Adhesive. Journal of Physical Chemistry, 117: 10492-503.

Hughes, H.V., J.P. Lisher, G.G. Hardy, D.T. Kysela, R.J. Arnold, D.P. Giedroc, and Y.V. Brun. 2013. Coordinate synthesis and protein localization in a bacterial organelle by the action of a penicillin-binding-protein. Molecular Microbiology, 90, 1162–1177. Cover image.

G. Liechti, E. Kuru, E. Hall, A. Kalinda, Y.V. Brun, M. VanNieuwenhze, and A. Maurelli. 2013. A new metabolic cell wall labeling method reveals peptidoglycan in Chlamydia trachomatis. Nature, doi:10.1038/nature12892. Highlighted in Nature Reviews Microbiology, Nature Methods, NIH Biomedical Beat, as a IU Top 2013 News, and on the NIH NIAID web site, F1000.

C. Jiang, P.J.B. Brown, A. Ducret, and Y.V. Brun. 2014. Co-option of a developmental regulator in the sequential evolution of bacterial morphology. Nature, http://dx.doi.org/10.1038/nature12900.