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Indiana University Bloomington

Erin CarlsonErin E. Carlson

Assistant Professor, Department of Chemistry

Office: Simon Hall 200B

Phone: 812/855-3665

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Lab Website

Education

B.A. 2000 St. Olaf College
Ph.D 2005 University of Wisconsin - Madison
Postdoctoral Fellowship 2008 The Scripps Research Institute

Research

Professor Carlson's research program focuses on the development and application of new technologies to explore the mechanisms of bacterial pathogenesis and identify potential therapeutic agents. To accomplish these goals, we work at the interface of chemistry and biology using techniques ranging from organic synthesis to mass spectrometry-based systems biology methods. In particular, we are pursuing the development of new technologies for natural product discovery including innovative methods for compound isolation, screening, and diversification. We are also utilizing state of the art metabolomic and proteomic methods to map the biochemical pathways associated with bacterial pathogenesis and antibiotic resistance.

Representative Publications

Sidebottom, A. M.; Johnson, A. R.; Karty, J. A.; Trader, D. J.; Carlson, E. E. Integrated Metabolomics Approach Facilitates Discovery of an Unpredicted Natural Product Suite from Streptomyces coelicolor M145. ACS Chem. Biol. 2013, DOI: 10.1021/cb4002798.

Trader, D. J. and Carlson, E. E. Taming of a Superbase for Selective Phenol Desilylation and Natural Product Isolation. J. Org. Chem. 2013, DOI: 10.1021/jo4010298.

Garber, K. C. A. and Carlson, E. E. Thiol-ene Enabled Detection of Thiophosphorylated Kinase Substrates. ACS Chem. Biol. 2013, DOI: 10.1021/cb400184v.

Francis, S.; Wilke, K. E.; Brown, D. E.; Carlson, E. E. Mechanistic Insight into Inhibition of Two-Component System Signaling. Med. Chem. Commun. 2013, 4, 269-277. Invited Article in the New Talent Themed Issue.

Kocaoglu, O.; Calvo, R. A.; Sham, L. T.; Cozy, L. M.;† Lanning, B. R.;† Francis, S.; Winkler, M. E.; Kearns, D. B.; Carlson, E. E. Selective Penicillin-Binding Protein Imaging Probes Reveal Substructure in Bacterial Cell Division. ACS Chem. Biol. 2012, 7, 1746-1753.

Wilke, K. E.; Francis, S.; Carlson, E. E. Activity-Based Probe for Histidine Kinase Signaling. J. Am. Chem. Soc. 2012, 134, 9150-9153.

Trader, D. J. and Carlson, E. E. Chemoselective Hydroxyl Group Transformation: An Elusive Target. Mol. BioSyst. 2012, 8, 2484-2493. Invited Review in Emerging Investigators Themed Issue.

Trader, D.J. and Carlson, E. E. Siloxyl Ether Functionalized Resins for Chemoselective Enrichment of Carboxylic Acids. Org. Lett. 2011, 13, 5652-5655.

Odendaal, A. Y.;† Trader, D. J.;† Carlson, E. E. Chemoselective Enrichment for Natural Products Discovery. Chem. Sci. 2011, 2, 760-764.

Carlson, E. E. Natural Products as Chemical Probes. ACS Chem. Biol. 2010, 5, 639-653.