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Indiana University Bloomington

David DalekeDavid Daleke

Associate Professor, Biochemistry and Molecular Biology Associate Dean, University Graduate School Vice Provost for Graduate Education and Health Sciences

Office: Myers Hall 200B

Phone: 812/855-6902

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Lab Website

Education

B.S., Stanford University, 1979
Ph.D. Stanford University, 1986.
American Cancer Society Postdoctoral Fellow, University of California at San Francisco
1986-88; Fellow, Indiana Molecular Biology Institute, 1988
Established Investigator, American Heart Association, 1994-1999
Indiana University School of Medicine Eminent Scholar, 1999

Research

Membrane structure and function; regulation of lipid organization by "flippases" in normal and diabetic blood cells.

Representative Publications

Yibin Liu, David L. Daleke and Alyce D. Fly, “Enhanced vascular function after acute fat-rich snacking in healthy males,” Nutrition Research 32 (2012) 565-572. PMID: 22935339.

Shelley Cook and David L. Daleke, “Substrate Specificity of the Aminophospholipid Flippase,” in Membrane Asymmetry and Transmembrane Motion of Lipids, Philippe Devaux and Andreas Herrmann, Eds., J. Wiley & Sons, Inc., 2012.

Magdalena Marek, Sigrid Milles, Gabriele Schreiber, David L. Daleke, Gunnar Dittmar, Andreas Herrmann, Peter Müller, and Thomas Güenther Pomorski, “The yeast plasma membrane ABC transporter Aus1: Purification, characterization and effect of lipids on its activity,” Journal of Biological Chemistry 286 (2011) 21835-21843.  PMID: 21521689.

Magdalena Marek, Sigrid Milles, Gabriele Schreiber, David L. Daleke, Gunnar Dittmar, Andreas Herrmann, Peter Müller, and Thomas Güenther Pomorski, “The yeast plasma membrane ABC transporter Aus1: Purification, characterization and effect of lipids on its activity, Journal of Biological Chemistry (2011) Apr 26. [Epub ahead of print]. PMID: 21521689.

Shelley Cook and David L. Daleke, “Substrate Specificity of the Aminophospholipid Flippase,” in Membrane Asymmetry and Transmembrane Motion of Lipids, Philippe Devaux, Ed., J. Wiley & Sons, Inc., 2011, in press.

Jennifer A. Meyer, Wasanthi Subasinghe, Anders A. F. Sima, Zachary Keltner, Gavin E. Reid, David Dalekeand Dana M. Spence, “Zinc-activated C-peptide Resistance to the Type 2 Diabetic Erythrocyte is Associated with Hyperglycemia-induced Phosphatidylserine Externalization and Reversed by Metformin,” Molecular BioSystems 5 (2009) 1157-1162. PMID: 19756305.

David L. Daleke, “Regulation of Phospholipid Asymmetry in the Erythrocyte Membrane,” Current Opinion in Hematology 15 (2008) 191-195. PMID: 18391783.

Smriti and David L. Daleke, “ATP-dependent Transport of Phosphatidylserine Analogs in Human Erythrocytes,” Biochemistry, 46 (2007) 2249-2259. PMID: 17269657.

David L. Daleke, “Phospholipid Flippases”, Journal of Biological Chemistry 282 (2007) 821-825 (invited review). PMID: 17130120.

Jill Paterson, Kathleen Renkema, Margaret Halleck, Robert Schlegel, Patrick Williamson and David L. Daleke, Lipid Specific Activation of the Murine P4-ATPase Atp8a1 (ATPase II),” Biochemistry 45 (2006) 5367-5376. PMID: 17130120.

Dana M. Niedowicz and David L. Daleke, “The Role of Oxidative Stress in Diabetic Complications,” Cell Biochemistry and Biophysics  43  (2005) 289-330. PMID: 16049352.

Peter R. Hoffmann, Jennifer A. Kench, Andrea Vondracek, Ellen Kruk, David L. Daleke, Michael Jordan, Philippa Marrack, Peter M. Henson, and Valerie A. Fadok, “Interaction between Phosphatidylserine and the Phosphatidylserine Receptor Inhibits Immune Responses In Vivo.”  J Immunol 174 (2005) 1393-1404. PMID: 15661897.

Jill V. Lyles, Kathleen Cornely-Moss, Christine M. Smith and David L. Daleke, “Purification of the Human Erythrocyte PS-Stimulated Mg2+-ATPase: A Putative Flippase,” Methods in Molecular Biology 228 (2003) 257-269. PMID: 12824559.

David L. Daleke, “Regulation of Transbilayer Plasma Membrane Phospholipid Asymmetry,” Journal of Lipid Research 44 (2003) 233-242. PMID: 12576505.

Mou Banerjee, Daryl C. Drummond, Arvind Srivastava, David L. Daleke, and Barry R. Lentz, “Specificity of Soluble Phospholipid Binding Sites on Human Factor Xa,” Biochemistry 41 (2002) 7751-7762. PMID: 12056907.

Xin Zhai, Arvind Srivastava, Daryl C. Drummond, David Daleke, and Barry R. Lentz, “Phosphatidylserine Binding Alters the Conformation and Specifically Enhances the Cofactor Activity of Bovine Factor Va,” Biochemistry 41 (2002) 5675-5684. PMID: 11969429.