Charles E. Dann III
Assistant Professor, Department of Chemistry
Office: Simon Hall 320D
B.S., ACS Chemistry Millsaps College 1996.
Ph.D. Biophysics & Biophysical Chemistry Johns Hopkins University
Postdoctoral Fellow University of Texas Southwestern Medical Center 2002
Protein structure-based drug design targeting cells involved in epithelial cancer and autoinflammatory disease. Biochemical, mechanistic, and X-ray crystallographic analyses of regulatory RNAs; developing riboswitch-based molecular sensors.
Guerra, A.J., Dann, C.E., 3rd, Giedroc, D.P. "Crystal Structure of the Zinc-Dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-Bound State." J Amer Chem Soc 133:49, 19614-7, 2011. doi: 10.1021/ja2080532
Dann, C.E., 3rd "RNA Structure: Riboswitch Strikes a Chord." Nat Chem Biol 7(10), 660-1, 2011. doi: 10.1038/nchembio.672
Packianathan, C., Katen, S.P., Dann, C.E., 3rd, Zlotnick, A. "Conformational changes in the hepatitis B virus core protein are consistent with a role for allostery in virus assembly." J Virol 84:3, 1607-15, 2010.
Grossoehme, N.E., Li, L., Keane, S.C., Liu, P., Dann, C.E., 3rd, Leibowitz, J.L., Giedroc, D. P. "Coronavirus N protein N-terminal domain (NTD) specifically binds the transcriptional regulatory sequence (TRS) and melts TRS-cTRS RNA duplexes." J Mol Bio 394:3, 544-57, 2009.
Dann, C.E. 3rd, Wakeman, C.A., Sieling, C.L., Baker, S.C., Irnov, I., and Winkler, W.C. "Structure and Mechanism of a Metal-Sensing Regulatory RNA." Cell 130:5, 878-92, 2007.
Wakeman, C.A., Winkler, W.C., and Dann, C.E. 3rd "Structural Features of Metabolite-Sensing Riboswitches." Trends Biochem Sci 32:9, 415-24, 2007.
Dann, C.E. 3rd and Winkler, W.C. "RNA allostery glimpsed." Nat Struct Mol Biol 13:7, 569-71, 2006 (News and Views).
Dann, C.E. 3rd, Bruick, R.K. "Dioxygenases as O2-dependent regulators of the hypoxic response pathway." Biochem Biophys Res Commun 338:1, 639-47, 2005 (review).
Shah, S., Lee, S.F., Tabuchi, K., Hao, Y.H., Yu, C., LaPlant, Q., Ball, H., Dann, C.E. 3rd, Sudhof, T., Yu, G. "Nicastrin functions as a gamma-secretase-substrate receptor." Cell 122:3, 435-47, 2005.
Hamaoka, B., Dann, C.E. 3rd, Geisbrecht, B.V., and Leahy, D.J. "Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA 2A." Proc Natl Acad Sci U S A 101:32, 11673-11678, 2004.
Dann, C.E. 3rd, Bruick, R.K. and Deisenhofer, J. "Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway." Proc Natl Acad Sci U S A 99:24, 15351-6, 2002.
Dann, C.E. 3rd, Hsieh, J.C., Rattner, A.., Sharma, D., Nathans, J. and Leahy, D.J. "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains." Nature 412, 86-90, 2001.
Ooi, S.L., Dann, C. 3rd, Nam, K., Leahy, D.J., Dahma, M.J., and Boeke, J.D. "Ribonucleases, Part A: Functional Roles and Mechanisms of Action. 'RNA lariat debranching enzyme.'" Methods in Enzymology 341, 2001.
Leahy, D.J., Dann, C.E. 3rd, Longo, P.,Perman, B., and Ramyar, K. "A mammalian expression vector for expression and purification of secreted proteins for structural studies." Protein Expression and Purification 20:3, 500-506, 2000.
Ward, T.J., Dann, C.E. 3rd, Brown, A.P. "Separation of enantiomers using vancomycin in a countercurrent process by suppression of electroosmosis." Chirality 8:1, 77-83, 1996.
Ward, T.J., Dann, C.E. 3rd, Blaylock, A. "Enantiomeric resolution using the macrocyclic antibiotics rifamycin B and rifamycin SV as chiral selectors for capillary electrophoresis." Journal of Chromatography A 715, 337-344, 1995.