Richard D.DiMarchi
Professor, Department of Chemistry
Education
B.S Florida Atlantic University 1974
Ph.D.Indiana University1974-1978
Post-Doctoral Fellowship Rockefeller University, 1978-1981
Research
Structure-activity relationships of macromolecules.
Representative Publications
Patterson, J., Ottaway, N., Gelfanov, V., Smiley, D., Perez-Tilve, D., Pfluger, P., Tschöp, M. and DiMarchi, R. A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1, ACS Chemical Biology (2011), 6(2), 135-45.
Patterson, J.., Day, J., Gelfanov, V., DiMarchi, R.. Functional Association of the N-Terminal Residues with the Central Region in Glucagon-Related Peptides, Journal of Peptide Science (2011), published online: 20 Jun 2011 doi: 10.1002/psc. 1385
Wiedmer, P., Strasser, F., Horvath, T. L., Blum, D., DiMarchi, R., Lutz, T., Schurmann, A., Joost, H.G., Tschop, M. H., Tong, J. Ghrelin-induced hypothermia: A Physiological Basis but No Clinical Risk Special Issue: Gut Brain Interactions, (2011) accepted.
De, A. and DiMarchi, R. Synthesis & Characterization of Ester-Based Prodrugs of Glucagon-Like Peptide 1, Peptide Science (2010) 94(4) 448-456
Perez-Tilve, D., Hofmann, S.M., Basford, J., Nogueiras, R., Pfluger, P.T., Patterson, J.T., Grant, E., Wilson-Perez, H., Granholm, N., Arnold, M., Trevasksi, J.L., Butler, A., Davidson, W.S., Woods, S.C., Benoit, S., Sleeman, M.W., DiMarchi, R.D., Hui D.Y., and Tschőp, M.H. Melanocortin signaling in the CNS directly regulates circulating cholesterol (2010) Nature Neuroscience 13, 877-882
Bohrer, B., Li, Y., Reilly, J., Clemmer, D., DiMarchi, R., Radivojac, P., Tang, H. and Arnold, R. Combinatorial Libraries of Synthetic Peptides as a Model for Shotgun Proteomics (2010) Anal. Chem. 82, 6559-6568.
Day, J., Li, P., Patterson, J., Chabenne, J., DiMarchi Chabenne, M., Gelfanov,. V., and DiMarchi, R. Charge Inversion at Position 68 of the Glucagon and Glucagon-like peptide-1 Receptors Supports Selectivity in Hormone Action, Peptides (2010), 17(3), 218-25.
Chabenne, J., DiMarchi Chabenne, M., Gelfanov, V., and DiMarchi, R. Optimization of the Native Glucagon Sequence for Medicinal Purposes Journal of Diabetes Science and Technology (2010), 4(6), 1322-31.
Habegger, K., Heppner, K., Geary, N., Bartness, T., DiMarchi, R. and Tschöp, M. The Metabolic Actions of Glucagon Revisited Nature Reviews Endocrinology (2010), 6(12), 689-97.
Ward, W.K., Massoud, R. G., Szybala, C. J., Engle, J. M., Youssef, J. E., Carroll, J. M., Roberts, C. T., DiMarchi, R.D. In Vitro and in Vivo Evaluation of Native Glucagon and Glucagon Analog (MAR-D28 during Aging: Lack of Cytotoxicity and Preservation of Hyperglycemic Effect Journal of Diabetes Science and Technology (2010), 4(6), 1311-1321.
Heppner, K. M., Habegger, K. M., Day, J., Pfluger, P. T., Perez-Tilve, D., Ward, B., Gelfanov, V., Woods, S. C., DiMarchi, R., Tschop, M. Glucagon Regulation of Energy Metabolism Physiology & Behavior (2010), 100(5), 545-8.
