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Indiana University Bloomington

Richard DiMarchiRichard D.DiMarchi

Standiford H. Cox Distiguished Professor, Chemistry/Linda & Jack Gill Chair in Biomolecular Sciences

Office:Chemistry A508

Phone: 812/856-1840

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Lab Website


B.S Florida Atlantic University 1974
Ph.D.Indiana University1974-1978 
Post-Doctoral Fellowship Rockefeller University, 1978-1981  


Structure-activity relationships of macromolecules.

Representative Publications

Patterson , J., Li, P., Day, J.W., Gelfanov, V. and DiMarchi, R. A Hydrophobic Site on the GLP-1 Extracellular Domain Orients the Peptide Ligand for Signal Transduction, Molecular Medicine (2013) 2:86-91.

Habegger, K., Stemmer, K., Cheng, C., Muller, T., Heppner K., Ottaway N, Holland, J., Hembree, J., Smiley, D., Gelfanov., V., Krishna, R., Arafat, A., Konkar, A., Belli, S., Kapps, M., Woods, S., Hofmnann, S., D’Alessio, D., Pfluger, P., Perez-Tilve., D., Seeley, R., Konishi, M., Itoh, N., Kharitonenkov, A., Spranger, J., DiMarchi, R. and Tschop, M., Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions, Diabetes Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH.Diabetes (2013) 62(5), 1453-63.

Campanello, G., Ma, Z., Grossoehme, N., Guerra, A., Ward, B., DiMarchi, R., Ye, Y., Dann C. and Giedroc, D. Allosteric Inhibition of a Zinc-Sensing Transcriptional Repressor: Insights into the Arsenic Repressor (ArsR) Family, J. Mol. Biol (2013) 425(7), 1143– 57.

Muller T., Habegger, K., Chun-Xia Y., Meyer C., Finan B., Heppner K., Ottaway N, Woods, S., Hofmnann, S., Pfluger, P., Perez-Tilve., D., Seeley, R., DiMarchi, R. and Tschop, M. The orphan receptor GPR83 regulates systemic energy metabolism via ghrelin-dependent and -independent mechanisms, (2013) Nature Methods 4:1968 (1-8).

Kuna R., Girada S., Asalla S., Vallentyne J., Patterson J., Smiley D., DiMarchi R., Mitra P. Glucagon-like Peptide1 Receptor Mediated Endosomal cAMP Generation Promotes Glucose Stimulated Insulin Secretion in Pancreatic beta Cells, (2013) AJP-Endocrinology and Metabolism Vol. 305: E161-E170.

Habegger K., Kirchner H., Yi C., Heppner K., Sweeney D., Ottaway N., Holland J., Amburgy S., Raver C., Krishna R., Müller T., Perez-Tilve D., Pfluger P., Obici S., DiMarchi R., D'Alessio D., Seeley R., and Tschöp M.  GLP-1R Agonism Enhances Adjustable Gastric Banding In Diet-Induced Obese Rats, Diabetes (2013) 62:3261-7.

Kaur, Z., Ochman, A., Mayer, J., Gelfanov, V. and DiMarchi R.D.  Discovery of High Potency, Single-Chain Insulin Analogs with a Shortened B-Chain and Nonpeptide Linker ACS Chemical Biology (2013), 8:1822-1829.

Ward B., Ottaway N., Ma D., Gelfanov V., Perez-Tilve D., Tschöp M., and DiMarchi R. Structural Changes Associated with Peptide Lipidation Broaden Biological Function, Molecular Metabolism (2013) 2(4):468–479.

Heppner K., Piechowski C., Müller A., Ottaway N., Sisley S., Smiley D., Habegger K., Pfluger P., DiMarchi R., Biebermann H., Tschöp M., Sandoval D., Perez-Tilve D. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via CNS ghrelin receptors, Diabetes (2013) 63:122-131.

Finan, B. Tao M., Ottaway, N. Müller, T., Habegger, K., Heppner, K., Kirchner, K., Holland, J., Hembree, J., Raver, C., Lockie, S., Smiley, D., Gelfanov, V., Yang, B., Hofmann, S., Bruemmer, D., Drucker, D., Pfluger, P., Perez-Tilve, D., Gidda, J., Vignati, L., Zhang, L., Hauptman, J.,  Lau, M., Brecheisen, M., Uhles, S., Riboulet, W., Hainaut, W., Sebokova, E., Conde-Knape, K., Konkar, A., DiMarchi, R., and Tschöp, M.  Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans Sci Transl Med 5, (2013); doi: 10.1126/scitranslmed.3007218.

Habegger, K., Heppner K., Amburgy, S., Ottaway N, Holland, J., Raver, C., Bartley, E., Muller, T., Perez-Tilve., D., Pfluger, P., Berger, J., Tourse, M., Benoit, S., R., DiMarchi, R., D’Alessio, D., Seeley, R., and Tschop, M. GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats, Diabetes (2014) 63:505-13, doi: 10.2337/db13-0511.

Zaykov, A., Mayer, J., Gelfanov V., and DiMarchi, R. Chemical synthesis of insulin analogs through a novel precursor ACS Chemical Biology ACS Chem. Biol., (2014), 9 (3), pp 683–691 doi: 10.1021/cb400792s.

Clemmensen, C., Chabenne, J., Finan, B., Sullivan L, Fischer, K., Kuchler, D., Sehrer, L., Ograjsek, T., Hofmann, S., Schriever, S., Pfluger P, Pinkstaff J, Tschöp M., DiMarchi R., and Müller T GLP-1/glucagon co-agonism restores leptin responsiveness in obese mice chronically maintained on a high-fat high-sugar diet Diabetes (2014) 63:1422-7, doi:10.2337/db13-1087.

Chabenne J., DiMarchi-Chabenne M., Zhao, Y., Levy, J., Smiley, D., Gelfanov, V., and DiMarchi R. A Glucagon analog chemically stabilized for immediate treatment of life-threatening hypoglycemia Molecular Metabolism 3 (2014), pp. 293-300

Cao, X., Xu, P., Oyola, M., Saito, K., Xia, Y., Yang, Y., Hinton, A., Wang, C., Zou, F., Yan, C., Yan, X., Ding, H., Zhu, L., Yu, L., Yang, B., Feng, Y., Khan, S., DiMarchi, R., Mani, S., Tong, Q., Xu, Y. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice J Clin Invest. 2014;124(10):4351–4362.

Kharitonenkov, A. and DiMarchi, R. Break on Through to the Other 1 Cell Metabolism 2014 Oct;20(4):554-5.

Schwenk, R., Baumeier, C., Finan, B., Kluth, O., Brauer, C., Joost, H-G, DiMarchi, R., Tschöp, M., and Schürmann, A. GLP-1-estrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone NZO mice Diabetologia (2014) DOI 10.1007/s00125-014-3478-3.

Finan, B., Yang, B., Ottaway, N., Perez-Tilve, D., Smiley, D., Tao M., Chabenne, J., Zhang, Pfluger, P., L., Habegger, K., Müller, T., Uhles, S., Riboulet, W., Hertel, C.,  Sebokova, E., Conde-Knape, K., Konkar, A., Bleicher, K., Drucker, D., Gelfanov, V., DiMarchi, R., and Tschöp, M.  Discovery of a Potent, Balanced, and Integrated Triple Agonist of Glucagon, GLP-1, and GIP that Safely Reverses Obesity Nature Medicine (2014) doi:10.1038/nm.3761.

Wu, F., Chabenne, J., Gelfanov, V., Mayer, J and DiMarchi, R. Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity J. Peptide Science (2014) (in print)

Hoover, S., Perez, A., Tsui, H.-C., Mukherjee, D., Smiley, D., DiMarchi, R., Winkler, M., and Lazazzera, B. A new Quorum Sensing System for Streptococcus pneumoniae D39 that Regulates Expression of a Lantibiotic Biosynthesis Gene Cluster Molecular Microbiology (2014) (in review)

Ottaway, N., Smith, E., Heppner, K., Smiley, D., Gelfanov, V., Gertler, A., Drucker, D., DiMarchi, R., D’Alessio, D., and Perez-Tilve, D. Essential role of the adipoinsular incretin axis in the metabolic adaptation to fasting Diabetes (2014) (in review)

Tiano, J., Tate, C., Yang, B., DiMarchi, R., and Mauvais-Jarvis, F. Effect of targeted estrogen delivery using glucagon-like peptide-1 on incretin-stimulated insulin secretion, insulin sensitivity and glucose homeostasis Diabetologia (2014) (in review)

Xu, P., Cao, X., Zhu, L., Yang, Y., Saito, K., Wang, C.,  Yan, X., Hinton, H., Zou, F., Ding, H., Xia   Y., Yan, C., Wu, S-P., Yan, B., Feng, Y., Clegg, D., DiMarchi, R., Khan, S., Tsai, S., DeMayo, F., Wu, Q. and Tong, Q. Estrogen Receptor-α in Medial Amygdala Neurons Regulates Body Weight in Both Genders JCI (2015) (in review)