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Indiana University Bloomington

Richard DiMarchiRichard D.DiMarchi

Professor, Chemistry

Office:Chemistry A508

Phone: 812/856-1840

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Lab Website


B.S Florida Atlantic University 1974
Ph.D.Indiana University1974-1978 
Post-Doctoral Fellowship Rockefeller University, 1978-1981  


Structure-activity relationships of macromolecules.

Representative Publications

Patterson , J., Li, P., Day, J.W., Gelfanov, V. and DiMarchi, R. A Hydrophobic Site on the GLP-1 Extracellular Domain Orients the Peptide Ligand for Signal Transduction, Molecular Medicine (2013) 2:86-91.

Habegger, K., Stemmer, K., Cheng, C., Muller, T., Heppner K., Ottaway N, Holland, J., Hembree, J., Smiley, D., Gelfanov., V., Krishna, R., Arafat, A., Konkar, A., Belli, S., Kapps, M., Woods, S., Hofmnann, S., D’Alessio, D., Pfluger, P., Perez-Tilve., D., Seeley, R., Konishi, M., Itoh, N., Kharitonenkov, A., Spranger, J., DiMarchi, R. and Tschop, M., Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions, Diabetes Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH.Diabetes (2013) 62(5), 1453-63

Campanello, G., Ma, Z., Grossoehme, N., Guerra, A., Ward, B., DiMarchi, R., Ye, Y., Dann C. and Giedroc, D. Allosteric Inhibition of a Zinc-Sensing Transcriptional Repressor: Insights into the Arsenic Repressor (ArsR) Family, J. Mol. Biol (2013) 425(7), 1143– 57

Muller T., Habegger, K., Chun-Xia Y., Meyer C., Finan B., Heppner K., Ottaway N, Woods, S., Hofmnann, S., Pfluger, P., Perez-Tilve., D., Seeley, R., DiMarchi, R. and Tschop, M. The orphan receptor GPR83 regulates systemic energy metabolism via ghrelin-dependent and -independent mechanisms,  Nature Methods 4:1968

Kuna R., Girada S., Asalla S., Vallentyne J., Patterson J., Smiley D., DiMarchi R., Mitra P. Glucagon-like Peptide1 Receptor Mediated Endosomal cAMP Generation Promotes Glucose Stimulated Insulin Secretion in Pancreatic beta Cells, AJP-Endocrinology and Metabolism (April 16, 2013) doi:10.1152/ajpendo.00551.2012

Habegger K., Kirchner H., Yi C., Heppner K., Sweeney D., Ottaway N., Holland J., Amburgy S., Raver C., Krishna R., Müller T., Perez-Tilve D., Pfluger P., Obici S., DiMarchi R., D'Alessio D., Seeley R., and Tschöp M.  GLP-1R Agonism Enhances Adjustable Gastric Banding In Diet-Induced Obese Rats Diabetes. (Jun 17, 2013) [Epub ahead of print]

Heppner K., Piechowski C., Müller A., Ottaway N., Sisley S., Smiley D., Habegger K., Pfluger P., DiMarchi R., Biebermann H., Tschöp M., Sandoval D., Perez-Tilve D. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via CNS ghrelin receptors, (submitted, Endocrinology March 2013)

Ward B., Ottaway N., Ma D., Gelfanov V., Perez-Tilve D., Tschöp M., and DiMarchi R. Structural Changes Associated with Peptide Lipidation Broaden Biological Function, (submitted,  Molecular Medicine July 2013)

Habegger, K., Heppner K., Amburgy, S., Ottaway N, Holland, J., Raver, C., Bartley, E., Muller, T., Perez-Tilve., D., Pfluger, P., Berger, J., Tourse, M., Benoit, S., R., DiMarchi, R., D’Alessio, D., Seeley, R., and Tschop, M. GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats, (submitted, Endocrinology July 2013)

Mu J., Pinkstaff J., Li Z., Skidmore L., Li N., Myler H., Dallas-Yang Q., Putnam A.M., Yao J., Bussell S., Wu M., Norman T.C., Rodriguez C.G., Kimmel B., Metzger J.M., Manibusan A., Lee D., Zaller D.M., Zhang B.B., DiMarchi R.D., Berger J.P., Axelrod D.W. FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents, Diabetes (2012), 61(2), 505-12.

Müller TD, Sullivan LM, Habegger K, Yi CX, Kabra D, Grant E, Ottaway N, Krishna R, Holland J, Hembree J, Perez-Tilve D, Pfluger PT, DeGuzman MJ, Siladi ME, Kraynov VS, Axelrod DW, DiMarchi R, Pinkstaff JK, Tschöp MH., Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21, J Pept Sci. (2012), 18(6), 383-93.

Day JW, Gelfanov VM, Smiley D, Carrington PE, Eiermann G, Chicchi G, Erion M, Gidda J, Thornberry NA, Tschöp M, Marsh DJ, SinhaRoy R, DiMarchi RD, Pocai A Optimization of Agonism at Glucagon and GLP-1 Receptors to Safely Maximize Weight Reduction in DIO-rodents, J. Peptide Science (2012) 98:443-50.

Tschöp MH, DiMarchi RD., Outstanding Scientific Achievement Award Lecture 2011: defeating diabesity: the case for personalized combinatorial therapies, Diabetes (2012), 61(6), 1309-14.

Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, Dimarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D.Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling, Diabetes. (2012) 61(11):2753-62

Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Acylation Type Determines Ghrelin's Effects on Energy Homeostasis in Rodents, Endocrinology (2012), 153(10), 4687-95

Finan, B., Yan, Y., Ottaway, N., Stemmer, K., Muller, T.D., Yi, C-X., Habegger, K., Schriever, S.C., Garcia-Caceres, C., Kabra, D.G., Hembree, J., Holland, J., Raver, C., Seeley, R.J., Han, W., Irmler, M., Beckers, J., de Angelis, M.H., Tiano, J.P., Mauvais-Jarvis, F., Rerez-Tilve, D., Pfluger, P., Zhang, L., Gelfanov, V., DiMarchi, R.D., and Tschoep, M.H. Targeted Estrogen Delivery Reverses the Metabolic Syndrome, Nature Medicine (2012)

Day, J., Li, P., Patterson, J., Chabenne, J., DiMarchi Chabenne, M., Gelfanov,. V., and DiMarchi, R. Charge Inversion at Position 68 of the Glucagon and Glucagon-like peptide-1 Receptors Supports Selectivity in Hormone Action, Peptides (2011), 17(3), 218-25.

Patterson , J., Ottaway, N., Gelfanov, V., Smiley, D., Perez-Tilve, D., Pfluger, P., Tschöp, M. and DiMarchi, R. A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1, ACS Chemical Biology (2011), 6(2), 135-45.

Wiedmer, Petra, Strasser, Florian, Horvath, Tamas L., Blum, David, DiMarchi, Richard, Lutz, Thomas, Schurmann, Annette, Joost, Hans-Georg, Tschop, Matthias H., Tong, Jenny Ghrelin-induced hypothermia:  A Physiological Basis but No Clinical Risk Physiol. Behav. (2011) 105(1) 43-51.

Patterson , J., Day, J.W., Gelfanov, V. and DiMarchi, R. Functional association of the N-terminal residues with the central region in glucagon-related peptides, Journal of Peptide Science (2011) 17(10) 659-66.

Cho H., Daniel T., Buechler Y.J., Litzinger D.C., Maio Z., Putnam A.M., Kraynov V.S., Sim B.C., Bussell S., Javahishvili T., Kaphle S., Viramontes G., Ong M., Chu S., Becky G.C., Lieu R., Knudsen N., Castiglioni P., Norman T.C., Axelrod D.W., Hoffman A.R., Schultz P.G., DiMarchi R.D., Kimmel B.E. Optimized clinical performance of growth hormone with an expanded genetic code, Proc Natl Acad Sci U S A. (2011) 108(22) 9060-5