Skip to main content
Indiana University Bloomington

John FoleyJohn Foley

Associate Professor, Medical Science

Office:Jordan Hall 108

Phone: 812/ 855-3189

Send Email

Education

Ph.D. University of Cincinnati, 1993

Research

Research in my laboratory is focused on two processes. The first is the cellular and molecular analysis of how the nipple develops and changes with pregnancy and lactation.  The long-term goal of this research is to create a strategy for regenerating this appendage in women who have had mastectomies as a result of their treatment for breast cancer.  The other major research area in my lab is the study of bone metastasis particularly as it relates to breast and lung cancer.  This work is focused on identifying the molecular signals that mediate the cross talk between the tumor cells and the bone microenvironment.  In addition, our studies with bone metastasis have developed a focus on the role of stem cells from both cancer and supporting cell lineages in coordinating the pathological cycles that lead to bone destruction.

Representative Publications

Nickerson NK, Mohammad KS, Gilmore JL, Crismore EC Bruzzaniti A, Guise TA, Foley J. (2012) Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad. PLoS One 7: 1-13

Ng CS, Wu P, Foley J, Foley A, Mc Donald M, Leal SM, Juan WT, Huang CJ, Lai YT,Lo WS, Chen CF, Zhang H Widelitz RB, Patel PI, Li WH Chuong CM. (2012) The frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis. Plos Genetics Jul;8(7):e1002748.

Foley J, Nickerson NK, Riese DJ, Hollenhorst PC, Lorch G and Foley, AM (2012) At the Crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone. Ondontology  100(2):109-29.

Nickerson NK, Mill CP,  Wu H-J,  Riese ,DJ II and  Foley J. (2013)  Autocrine-Derived EGFR Ligands Contribute to Recruitment of Tumor-Associated Macrophage and Growth of Basal Breast Cancer Cells In Vivo Oncology Research 20: 303-17

Lin SJ, Foley J, Jiang TX, Yeh CY, Wu P, Foley A, Yen CM, Huang YC, Cheng HC, Chen CF, Reeder B, Jee SH, Widelitz RB, Chuong CM. (2013) Topology of Feather Melanocyte Progenitor Niche Allows Complex Pigment Patterns to Emerge. Science 340(6139):1442-5

Koyama S.  Wu, H-J Easwaran T, Tholpady S and Foley J. (2013) The Nipple: A Simple Intersection of Mammary Gland and Integument, but Focal Point of Organ Function.  J Mammary Gland Biol Neoplasia 18: 121-31

Foley J. Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, Dunbar ME, Philbrick WP, Wysolmerski, JJ (2001) Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development. 128: 513-525 PMID: 11171335

Mayer J, Foley, J, Chuong, C-M and Widelitz, RB (2008) Conversion of the Nipple to Hair Bearing Epithelia by Lowering BMP Pathway Activity at the Dermal-Epidermal Interface.   American Journal of Pathology 173: 1339-1347 PMID: 18832580

Lorch G, Viatchenko-Karpinski S, Ho H-T, Dirksen WP, Toribio RE, Foley J, Gyorke S and Rosol TJ (2011) The calcium-sensing receptor is necessary for the rapid development of hypercalcemia in human squamous cell carcinoma. Neoplasia 13: 428-438 PMID: 21532883

Nickerson NK, Mohammad KS, Gilmore JL, Crismore EC Bruzzaniti A, Guise TA, Foley J. (2012) Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad. PLoS One 7: 1-13 PMID: 22276166

Ng CS, Wu P, Foley J Foley A, Mcdonald ML, Juan WT, Huang C-J, Lai Y-T, Lo W-S, Chen C-F, Leal SM, Zhang H, Widelitz RG, Prangna PI, L W-H, Chuong C-M (2012) The chicken frizzle feather is due to an á-keratin (KRT75) mutation that causes a defective rachis. 2012 Jul;8(7):e1002748. Epub 2012 Jul 19 PMID: 22829773

Foley J, Nickerson NK, Riese DJ, Hollenhorst PC, Lorch G and Foley, AM (2012) At theCrossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone. Ondontology 2012 Jul;100(2):109-29

Nickerson NK, Mill CP,  Wu H-J,  Riese,DJ II and  Foley J. (2013) Autocrine-Derived EGFR Ligands Contribute to Recruitment of Tumor-Associated Macrophage and Growth of Basal Breast Cancer Cells In Vivo Oncology Research accepted

Lin SJ, Foley J, Jiang TX, Yeh CY, Wu P, Foley A, Yen CM, Huang YC, Cheng HC, Chen CF, Reeder B, Jee SH, Widelitz RB, Chuong CM. (2013) Topology of Feather Melanocyte Progenitor Niche Allows Complex Pigment Patterns to Emerge. Science 340(6139):1442-5. PMID: 23618762

Koyama S, Wu H-J, Easerwan T, Tholpady S, Foley J.  (2013) The Nipple: A Simple Intersection of Mammary Gland and Integument, but Focal Point of Organ Function J. Mammary Gland Biology and Neoplasia E-pulished May 1

Koyama S, Soini HA, Foley J, Novotony MV, Lai C. Title:  Sexually dimorphic enhancement of cell proliferation in the subventricular zone of the brain by synthetic pheromones. (accepted ) Frontiers in Neuroscience