Office:Jordan Hall 108
Phone: 812/ 855-3189
Ph.D. University of Cincinnati, 1993
Research in my laboratory is focused on two processes. The first is the cellular and molecular analysis of how the nipple develops and changes with pregnancy and lactation. The long-term goal of this research is to create a strategy for regenerating this appendage in women who have had mastectomies as a result of their treatment for breast cancer. The other major research area in my lab is the study of bone metastasis particularly as it relates to breast and lung cancer. This work is focused on identifying the molecular signals that mediate the cross talk between the tumor cells and the bone microenvironment. In addition, our studies with bone metastasis have developed a focus on the role of stem cells from both cancer and supporting cell lineages in coordinating the pathological cycles that lead to bone destruction.
Lorch G, Viatchenko-Karpinski S, Ho H-T, Dirksen WP, Toribio RE, Foley J, Gyorke S and Rosol TJ (2011) The calcium-sensing receptor is necessary for the rapid development of hypercalcemia in human squamous cell carcinoma. Neoplasia 13: 428-438
Foley J, Nickerson NK, Nam S, Allen KT, Gilmore JL, Nephew KP, Riese DJ 2nd. (2010) EGFR signaling in breast cancer: Bad to the bone Semin Cell Dev Biol. 21: 951-60
Toribio RE, Brown HA, Novince CM, Marlow B, Hernon K, Lanigan LG, Hildreth Iii BE, Werbeck JL, Shu ST, Lorch G, Carlton M, Foley J, Bokaya P, McCauley LK, Rosol TJ. (2010) The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. FASEB J. 2010 FASEB J. 24(6):1947-57
Gilmore JL, Gonterman RM, Menon K, Lorch G, Riese DJ II, (2009) Robling A and Foley J. Reconstitution of amphiregulin-EGFR signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone. Molecular Cancer Research 7:1714–28
Mayer J, Foley, J, Chuong, C-M and Widelitz, RB (2008) Conversion of the Nipple to Hair Bearing Epithelia by Lowering BMP Pathway Activity at the Dermal-Epidermal Interface. American Journal of Pathology, 173: 1339
Widelitz, RB Veltmaat J, Mayer J Foley, J and Chuong C-M (2007) Mammary glands and feathers: Comparing two skin appendages which help define novel classes during vertebrate evolution Seminars in Cell and Developmental Biology.
Eastwood J, Offutt CD, Menon K, Keel M Hrncirova P, Novotny MV, Arnold R and Foley J. (2006) Identification of markers for nipple epidermis: changes during pregnancy and lactation. Differentiation 74: 1-9
Diamond AG, Gonterman RM, Anderson A, Menon K, Offutt CD, Weaver C, Philbrick WM and Foley J. (2006) Parathyroid hormone related-protein and the PTH receptor regulate angiogenesis of the skin. Journal of Investigative Dermatology 126:2127-34
Richard V., Rosol T.J. Foley J. (2005) PTHrP gene expression in cancer: do all paths lead to Ets? Critical Reviews in Eukaryotic Gene Expression. 15:115-32,
Cho, Y-M., Lewis D. A., Koltz P. F., Richard V., Rosol T. J., Konger R. L., Spandau D.F. Foley J. (2004) Regulation of Parathyroid Hormone-related Protein gene expression by EGF family ligands in primary human keratinocytes Journal of Endocrinology 181: 179-190