Patricia Foster

Professor

Education

Ph.D., Cambridge University, UK, 1978
Postdoctoral Fellow, MIT, 1978-80
Harvard Medical School, 1980-84

Research

Mutagenesis, DNA repair, replication, and recombination 

Representative Publications

Foster, P.L. 2007  Stress-Induced Mutagenesis in Bacteria.  Critical Reviews in Biochemistry and Molecular Biology. 42:373-397.

Williams, A.B., and P.L. Foster. 2007 The Escherichia coli histone-like protein HU has a role in stationary phase adaptive mutation. Genetics 177:723-735.

Stumpf, J.D., A.R. Poteete, and P.L. Foster. 2007 Amplification cannot account for adaptive mutation in Escherichia coli. J. Bacteriol. 189:2291-2299.

Stumpf, J.D. and P.L. Foster 2005 Polyphosphate kinase regulates error-prone replication by DNA polymerase IV in Escherichia coli. Molec. Microbiol. 57:751-761.

Foster, P.L. 2006 Methods for Determining Spontaneous Mutation Rates. Methods in Enzymology 409: 195-213.

Layton, J.C. and P.L. Foster 2005. Error-prone DNA polymerase IV is regulated by the heat-shock chaperone GroE in Escherichia coli. J. Bacteriol. 187:449-457.

Foster, P.L. 2004 Adaptive Mutation in Escherichia coli J. Bacteriol 186:4846-4852.

Tompkins, J.D., J.L. Nelson, J.C. Hazel, H.L. Leugers, J.D. Stumpf, and P.L. Foster 2003. Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli. J. Bacteriol. 185:3469-3472.

Layton, J.C. and P.L. Foster 2003 Error-prone DNA polymerase IV is controlled by the stress-response sigma factor, RpoS, in Escherichia coli. Molec. Microbiol. 50:549-561.

Cairns J. and P.L. Foster. 2003. The risk of lethals for hypermutating bacteria in stationary phase. Genetics. 165:2317-2318.

Rodriguez, C, J. Tompkins, J. Hazel, and P.L. Foster 2002 Induction of a DNA nickase in the presence of its target site stimulates adaptive mutation in Escherichia coli. J. Bacteriol. 184:5599-5608 .